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公开(公告)号：US06908764B2
公开(公告)日：2005-06-21
申请号：US10190963
申请日：2002-07-08
申请人： Stefan Czichos , Joerg Lauber , Hubert Mayer , Gerhard Gross
发明人： Stefan Czichos , Joerg Lauber , Hubert Mayer , Gerhard Gross
CPC分类号： C12N5/0652 , A61K35/12 , C12N2501/60 , C12N2510/00
摘要： The invention relates to a recombinant human cell of undifferentiated mesenchyma for bone and cartilage cell formation, the human cell having the ability to express Tbr-1, Brachyury or another member of the T-box family.
摘要翻译： 本发明涉及用于骨和软骨细胞形成的未分化间质的重组人细胞，所述人细胞具有表达Tbr-1，Brachyury或T盒家族的另一成员的能力。
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公开(公告)号：US06849255B2
公开(公告)日：2005-02-01
申请号：US10067980
申请日：2002-02-08
申请人： Dan Gazit , Yoram Zilberman , Gadi Turgeman , Gadi Pelled , Gerhard Gross , Stefan Czichos , Andrea Hoffmann
发明人： Dan Gazit , Yoram Zilberman , Gadi Turgeman , Gadi Pelled , Gerhard Gross , Stefan Czichos , Andrea Hoffmann
CPC分类号： C12N5/0655 , A61K35/12 , C12N2510/00
摘要： The invention relates to methods of enhancing repair of a cartilage and/or inducing formation of a cartilage by administering a cell which expresses a factor of the T-box family, which includes inter-alia the brachyury. In another embodiment, the invention relates to an engineered cell, which is transfected with a vector comprising a nucleic acid sequence encoding a factor of the T-box family, thereby expressing a factor of the T-box family. In another embodiment, the invention relates to compositions comprising a vector which comprises a nucleic acid sequence encoding a factor of the T-box family and in another embodiment the composition comprising cell which expresses a factor of the T-box family, which includes inter-alia the brachyury.
摘要翻译： 本发明涉及增强软骨修复和/或诱导软骨形成的方法，该方法是通过施用表达T盒家族的因子的细胞，其特别包括brachyury。 在另一个实施方案中，本发明涉及工程改造的细胞，其用包含编码T盒家族因子的核酸序列的载体转染，从而表达T盒家族的因子。 在另一个实施方案中，本发明涉及包含载体的组合物，所述载体包含编码T盒家族因子的核酸序列，在另一个实施方案中，包含表达T盒家族因子的细胞的组合物包括： 特别是brachyury。
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