公开(公告)号：US11103733B2

公开(公告)日：2021-08-31

申请号：US12664666

申请日：2008-06-30

申请人： Stefan Müller ,  Brigitte Lindemann ,  Bernd Herzog

发明人： Stefan Müller ,  Brigitte Lindemann ,  Bernd Herzog

IPC分类号： A61Q17/04 ,  A61K8/11 ,  A61K8/58 ,  A61K8/37 ,  A61K8/35 ,  A61K8/44 ,  A61K8/81 ,  A61K8/893 ,  A61K8/49

摘要： The instant invention refers to the use of a concentrated aqueous polymer dispersion with an average particle size of less than 1000 nm comprising (a) a polymer carrier prepared by heterophase radical polymerization of at least one ethylenically unsaturated monomer in the presence of (b) an oil-soluble organic UV absorber selected from the class of p-aminobenzoic acid derivatives; salicylic acid derivatives; benzophenone derivatives; diphenyl acrylate derivatives; benzofuran derivatives; polymeric UV absorbers, comprising one or more organosilicon radicals; cinnamic acid derivatives; camphor derivatives; s-triazine derivatives; trianilino-s-triazine derivatives; menthyl anthranilates; and benzotriazole derivatives; wherein the weight ratio of the oil-soluble organic UV absorber (b) to polymer carrier (a) is greater than 50 parts UV absorber per 100 parts of carrier; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The concentrated aqueous polymer dispersions show unexpectedly high sunscreen effects and a positive skin feeling.

公开(公告)号：US20100008873A1

公开(公告)日：2010-01-14

申请号：US11919104

申请日：2006-04-20

申请人： Stefan Müller ,  Jochen Giesinger ,  Thomas Ehlis ,  Bernd Herzog ,  Peter König ,  Gilbert Kreyer ,  Katja Quass

发明人： Stefan Müller ,  Jochen Giesinger ,  Thomas Ehlis ,  Bernd Herzog ,  Peter König ,  Gilbert Kreyer ,  Katja Quass

IPC分类号： A61K8/49 ,  A61P17/04

CPC分类号： A61Q17/04 ,  A61K8/496 ,  A61K2800/52

摘要： Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.

摘要翻译： 式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; C1C5烷氧基 C1-C5烷氧基羰基; C5-C7环烷基; C6-C10芳基; 芳烷基 -SO3M; 式（1a）的基团R 3是氢; C 1 -C 5烷基; C1C5烷氧基 卤素，优选Cl; 或羟基; R4和R5各自独立地为氢; 或d-C 5烷基; m为1或2; n为0或1; 如果m = 1，则R2为氢; 未取代或苯基取代的d-C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）p - ; p为1〜3; 用于增强包含至少一种另外的有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。

公开(公告)号：US08361446B2

公开(公告)日：2013-01-29

申请号：US11919104

申请日：2006-04-20

申请人： Stefan Müller ,  Jochen Giesinger ,  Thomas Ehlis ,  Bernd Herzog ,  Peter König ,  Gilbert Kreyer ,  Katja Quass

发明人： Stefan Müller ,  Jochen Giesinger ,  Thomas Ehlis ,  Bernd Herzog ,  Peter König ,  Gilbert Kreyer ,  Katja Quass

IPC分类号： A61K8/49 ,  A61P17/04

CPC分类号： A61Q17/04 ,  A61K8/496 ,  A61K2800/52

摘要： Use of benzotriazole derivatives of formula (1), wherein R1 is C1-C30alkyl; C1C5alkoxy; C1-C5alkoxycarbonyl; C5-C7cycloalkyl; C6-C10aryl; aralkyl; —SO3M; a radical of formula (1a) R3 is hydrogen; C1C5alkyl; C1C5alkoxy; halogen, preferably Cl; or hydroxy; R4 and R5 are each independently of the other hydrogen; or d-C5alkyl; m is 1 or 2; n is O or 1; if m=1, R2 is hydrogen; unsubstituted or phenyl-substituted d-C1-C12alkyl; or C6-C10aryl; if m=2, R2 is the direct bond; or —(CH2)p—; and p is 1 to 3; for enhancing the photostability of cosmetic or dermatologic compositions comprising at least one further organic UV absorber.

摘要翻译： 式（1）的苯并三唑衍生物的用途，其中R 1是C 1 -C 30烷基; C1C5烷氧基 C1-C5烷氧基羰基; C5-C7环烷基; C6-C10芳基; 芳烷基 -SO3M; 式（1a）的基团R 3是氢; C 1 -C 5烷基; C1C5烷氧基 卤素，优选Cl; 或羟基; R4和R5各自独立地为氢; 或d-C 5烷基; m为1或2; n为0或1; 如果m = 1，则R2为氢; 未取代或苯基取代的d-C 1 -C 12烷基; 或C 6 -C 10芳基; 如果m = 2，则R2是直接键; 或 - （CH 2）p - ; p为1〜3; 用于增强包含至少一种另外的有机UV吸收剂的化妆品或皮肤病学组合物的光稳定性。

公开(公告)号：US08119107B2

公开(公告)日：2012-02-21

申请号：US11663610

申请日：2005-09-19

申请人： Stefan Müller ,  Bernd Herzog ,  Katja Quass

发明人： Stefan Müller ,  Bernd Herzog ,  Katja Quass

IPC分类号： A61Q17/02

CPC分类号： A61K8/066 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/415 ,  A61K8/893 ,  A61K8/97 ,  A61K2800/52 ,  A61K2800/57 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00

摘要： Disclosed is the use of an effective photo-stabilizing amount of stabilizing agent (a) selected from a diphenylacrylate UV filter (a1), a benzylidene amphor derivative (a2), an organosiloxane comprising benzalemalonate groups (a3), a fluoren derivative (a4), and a naphthalene dicarboxylic acid derivative (a5) for improving the stability with respect to UV radiation of a cosmetic or dermatological composition comprising a UV filter combination of at least one dibenzoylmethane derivative (b) and of at least one specific amino-substituted 2-hydroxybenzophenone derivative (c).

摘要翻译： 公开了使用有效的光稳定剂量的选自二苯基丙烯酸酯紫外线过滤器（a1），亚苄基双酚衍生物（a2），包含亚苄基丙二酸酯基（a3）的有机硅氧烷，芴衍生物（a4） 和用于提高化妆品或皮肤病学组合物的UV辐射稳定性的萘二羧酸衍生物（a5），其包含至少一种二苯甲酰甲烷衍生物（b）和至少一种特定氨基取代的2- 羟基二苯甲酮衍生物（c）。

公开(公告)号：US20100284950A1

公开(公告)日：2010-11-11

申请号：US12664666

申请日：2008-06-30

申请人： Stefan Müller ,  Brigitte Lindemann ,  Bernd Herzog

发明人： Stefan Müller ,  Brigitte Lindemann ,  Bernd Herzog

IPC分类号： A61K8/37 ,  A61K8/33 ,  A61K8/49 ,  A61Q17/04 ,  A61Q5/00

CPC分类号： A61Q17/04 ,  A61K8/11 ,  A61K8/35 ,  A61K8/37 ,  A61K8/44 ,  A61K8/445 ,  A61K8/496 ,  A61K8/4966 ,  A61K8/585 ,  A61K8/8152 ,  A61K8/893 ,  A61K2800/413

摘要： The instant invention refers to the use of a concentrated aqueous polymer dispersion with an average particle size of less than 1000 nm comprising (a) a polymer carrier prepared by heterophase radical polymerization of at least one ethylenically unsaturated monomer in the presence of (b) an oil-soluble organic UV absorber selected from the class of p-aminobenzoic acid derivatives; salicylic acid derivatives; benzophenone derivatives; diphenyl acrylate derivatives; benzofuran derivatives; polymeric UV absorbers, comprising one or more organosilicon radicals; cinnamic acid derivatives; camphor derivatives; s-triazine derivatives; trianilino-s-triazine derivatives; menthyl anthranilates; and benzotriazole derivatives; wherein the weight ratio of the oil-soluble organic UV absorber (b) to polymer carrier (a) is greater than 50 parts UV absorber per 100 parts of carrier; for the protection of human and animal hair and skin against the damaging effect of UV radiation. The concentrated aqueous polymer dispersions show unexpectedly high sunscreen effects and a positive skin feeling.

摘要翻译： 本发明涉及使用平均粒度小于1000nm的浓缩水性聚合物分散体，其包含（a）通过至少一种烯键式不饱和单体的异相自由基聚合制备的聚合物载体，所述聚合物载体在（b） 选自对氨基苯甲酸衍生物类的油溶性有机UV吸收剂; 水杨酸衍生物; 二苯甲酮衍生物; 二苯基丙烯酸酯衍生物; 苯并呋喃衍生物; 包含一个或多个有机硅基团的聚合物UV吸收剂; 肉桂酸衍生物; 樟脑衍生物 三嗪衍生物; 三苯胺三嗪衍生物; 薄荷基邻氨基苯甲酸酯; 和苯并三唑衍生物; 其中油溶性有机UV吸收剂（b）与聚合物载体（a）的重量比相对于100份载体大于50份UV吸收剂; 用于保护人体和动物毛发和皮肤免受紫外线辐射的破坏作用。 浓缩的水性聚合物分散体表现出意想不到的高防晒效果和阳性皮肤感觉。

公开(公告)号：US08393556B2

公开(公告)日：2013-03-12

申请号：US12664429

申请日：2008-06-27

申请人： Stefan Müller ,  Bernd Herzog

发明人： Stefan Müller ,  Bernd Herzog

IPC分类号： B02C15/00

CPC分类号： C07D251/24 ,  A61K8/4966 ,  A61K2800/412 ,  A61K2800/413 ,  A61Q17/04 ,  B82Y5/00

摘要： Disclosed is a method of preparing a composition, comprising a micronized insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus comprising yttrium-stabilized zirconium oxide grinding beads, in the presence of alkyl polyglucoside having the formula CnH2n+1O(C6H10O5)xH, in which n is an integer ranging from 8 to 16 and x is the mean polymerisation level of the glucoside moiety (C6H10O5) and ranges from 1.4 to 1.6, or an ester thereof and in the presence of an antifoam agent as dispersingagent auxiliary.

摘要翻译： 公开了一种制备组合物的方法，该组合物包含微粉化的不溶性有机UV吸收剂，该方法包括在包含钇稳定的氧化锆研磨珠的研磨装置中，在烷基存在下研磨粗颗粒形式的不溶性有机UV吸收剂 具有式C n H 2n + 10（C 6 H 10 O 5）x H的聚葡萄糖苷，其中n是8至16的整数，x是葡萄糖苷部分（C 6 H 10 O 5）的平均聚合水平，范围为1.4至1.6，或其酯， 消泡剂作为分散助剂的存在。

公开(公告)号：US08535648B2

公开(公告)日：2013-09-17

申请号：US12520880

申请日：2008-01-16

申请人： Barbara Wagner ,  Bernd Herzog ,  Stefan Müller ,  Thomas Ehlis

发明人： Barbara Wagner ,  Bernd Herzog ,  Stefan Müller ,  Thomas Ehlis

IPC分类号： A61K8/00

CPC分类号： A61K8/41 ,  A61K8/35 ,  A61K8/44 ,  A61K2800/52 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q5/04 ,  A61Q5/06 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/004 ,  A61Q19/04

摘要： Disclosed is the use of merocyanine derivatives of formula (1) for stabilizing UV-sensitive active ingredients like dibenzoylmethane derivatives.

摘要翻译： 公开了式（1）的部花青衍生物用于稳定紫外线敏感活性成分如二苯甲酰甲烷衍生物的用途。

公开(公告)号：US20100143272A1

公开(公告)日：2010-06-10

申请号：US11663610

申请日：2005-09-19

申请人： Stefan Müller ,  Bernd Herzog ,  Katja Quass

发明人： Stefan Müller ,  Bernd Herzog ,  Katja Quass

IPC分类号： A61K8/36 ,  A61Q17/04

CPC分类号： A61K8/066 ,  A61K8/35 ,  A61K8/37 ,  A61K8/40 ,  A61K8/415 ,  A61K8/893 ,  A61K8/97 ,  A61K2800/52 ,  A61K2800/57 ,  A61Q5/02 ,  A61Q5/12 ,  A61Q17/04 ,  A61Q19/00

摘要： Disclosed is the use of an effective photo-stabilizing amount of stabilizing agent (a) selected from a diphenylacrylate UV filter (a1), a benzylidene amphor derivative (a2), an organosiloxane comprising benzalemalonate groups (a3), a fluoren derivative (a4), and a naphthalene dicarboxylic acid derivative (a5) for improving the stability with respect to UV radiation of a cosmetic or dermatological composition comprising a UV filter combination of at least one dibenzoylmethane derivative (b) and of at least one specific amino-substituted 2-hydroxybenzophenone derivative (c).

摘要翻译： 公开了使用有效的光稳定剂量的选自二苯基丙烯酸酯紫外线过滤器（a1），亚苄基双酚衍生物（a2），包含亚苄基丙二酸酯基（a3）的有机硅氧烷，芴衍生物（a4） 和用于提高化妆品或皮肤病学组合物的UV辐射稳定性的萘二羧酸衍生物（a5），其包含至少一种二苯甲酰甲烷衍生物（b）和至少一种特定氨基取代的2- 羟基二苯甲酮衍生物（c）。

公开(公告)号：US07790769B2

公开(公告)日：2010-09-07

申请号：US12086647

申请日：2006-12-11

申请人： Barbara Wagner ,  Astrid Walther ,  Bernd Herzog

发明人： Barbara Wagner ,  Astrid Walther ,  Bernd Herzog

IPC分类号： A61K31/136 ,  C07C211/26

CPC分类号： C07C317/44 ,  C07C255/31 ,  C07C2601/16

摘要： Disclosed are merocyanine derivatives of formula (1), wherein R1 and R2 independently from each other are branched C4-C22alkyl; or branched C4-C12 alkenyl; R3 and R4 independently from each other are cyano; COR7, COOR7; CONR7R8; SO2(C6-C12)aryl; C2-C12alk-1-enyl; C3-C12cycloalk-1-enyl; C2-C12alk-1-inyl; C2-C12heteroalkyl; C3-C5heterocycloalkyl; C6-C10aryl; or C1-C9heteroaryl; wherein at least one of R3 and R4 is cyano; R5 and R6 independently from each other are hydrogen; C1-C6alkyl; C5-C8cycloalkyl which may be substituted by one or more than one C1-C4alkyl; and R7 and R8 independently from each other are hydrogen; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; —(CH2)tCOOH; C7-C12aralkyl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C6-C10aryl; C1-C9heteroaryl. The compounds are useful as UV absorbers for protecting human hair and skin against the damaging effect of UV radiation.

摘要翻译： 公开了式（1）的部花青衍生物，其中R 1和R 2彼此独立地为支链C 4 -C 22烷基; 或支链C 4 -C 12烯基; R 3和R 4彼此独立地是氰基; COR7，COOR7; CONR7R8; SO2（C6-C12）芳基; C2-C12烷-1-烯基; C 3 -C 12环烯-1-烯基; C2-C12alk-1-inyl; C 2 -C 12杂烷基; C3-C5杂环烷基; C6-C10芳基; 或C 1 -C 9杂芳基; 其中R 3和R 4中的至少一个是氰基; R5和R6彼此独立地是氢; C1-C6烷基; 可被一个或多于一个C 1 -C 4烷基取代的C 5 -C 8环烷基; 并且R 7和R 8彼此独立地是氢; C 1 -C 22烷基; C 2 -C 12烯基; C 2 -C 12炔基; C 3 -C 12环烷基; C3-C12环烯基; - （CH 2）t COOH; C7-C12芳烷基; C 1 -C 12杂烷基; C 2 -C 11杂芳烷基; C6-C10芳基; C1-C9杂芳基。 这些化合物可用作紫外线吸收剂，用于保护人体毛发和皮肤免受紫外线辐射的破坏作用。

公开(公告)号：US07772242B2

公开(公告)日：2010-08-10

申请号：US11630489

申请日：2005-06-20

申请人： Barbara Wagner ,  Frank Bienewald ,  Heinz Wolleb ,  Olof Wallquist ,  Bernd Herzog ,  Thomas Ehlis ,  Jürg Haase

发明人： Barbara Wagner ,  Frank Bienewald ,  Heinz Wolleb ,  Olof Wallquist ,  Bernd Herzog ,  Thomas Ehlis ,  Jürg Haase

IPC分类号： A61K31/519 ,  A61K31/445 ,  A61K31/16 ,  A61K31/165

CPC分类号： A61K8/498 ,  A61K8/4913 ,  A61K8/494 ,  A61Q17/04

摘要： Disclosed is the use of the compounds of formula  wherein Q is —OH; —OR7; —NH2; —NHR7; —NR7R8; or —N═R9; T is —COR5; —CN; or —SO2—(C6-C12)aryl; R1 is hydrogen; —OR7, —SR7; —NHR7; —NR7R8; C1-C22alkyl; C2-C12Alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl, C2-C11heteroaralkyl; C6-C10aryl; or C1-C9heteroaryl; R2 and R3 independently from each other are C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl, C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl; C3-C12cycloheteroalkyl; C2-C11heteroaralkyl, C6-C10aryl; or C1-C9heteroaryl; R4 is cyano; COR7, COOR7; CONH2; CONHR7; CONR7R8; SO2(C6-C12)aryl, C2-C12alk-1 -enyl; C3-C12cycloalk-1-enyl; C2-C12alk-1-inyl; C2-C12heteroalkyl, C3-C5heterocycloalkyl, C6-C10aryl; or C1-C9heteroaryl; R5 is —COR7; —COOR7; —OR7; —SR7, —NHR7, —NR7R8; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12alkylphenyl; C1-C12alkoxy-C6-C10aryl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C3-C12cycloheteroalkyl; C6-C10aryl; C1-C12alkoxy-C6-C10aryl or C1-C9heteroaryl; R6, R7 and R8 independently from each other are hydrogen; C1-C22alkyl; C2-C12alkenyl; C2-C12alkinyl; C3-C12cycloalkyl; C3-C12cycloalkenyl; C7-C12aralkyl; C1-C12heteroalkyl; C2-C11heteroaralkyl; C6-C10aryl; o-C6-C10aryl; or C1-C9heteroaryl; R9 is a (C1-C6)alkylidene radical; or R1 and R2, R1 and Q, R1 and R4, R1 and R6, R2 and R3, R3 and Q, R6 and Q, T and Q, each independently, are linked together, so that 1, 2, 3 or 4 carbocyclic or N, O and/or S-heterocyclic rings are formed, wherein each of them, independently from each other, may be condensed with an aromatic or heteroaromatic ring, and/or more N-, O- and/or S-heterocycic rings, and each N atom in a N-heterocyclic ring may be substituted by C1-C22alkyl; and n is a number from 1 to 4; for protecting of human hair and skin against the damaging effect of UV radiation.