公开(公告)号：US20140161899A1

公开(公告)日：2014-06-12

申请号：US14116491

申请日：2012-05-14

申请人： Stefan Schulte ,  Uwe Kalina ,  Michael Moses ,  Annette Feussner

发明人： Stefan Schulte ,  Uwe Kalina ,  Michael Moses ,  Annette Feussner

IPC分类号： A61K35/16

CPC分类号： A61K35/16 ,  A61K31/727 ,  A61K38/385 ,  A61K38/57 ,  C12Y304/21008 ,  C12Y304/21027 ,  C12Y304/21038

摘要： The instant invention provides a method to reduce adverse events caused by a pharmaceutical preparation derived from a plasma fraction wherein the method comprises contacting the plasma fraction with heparin or a heparin-like substance thereby reducing the activity of at least one activated serine proteaseper ml of the plasma fraction.

摘要翻译： 本发明提供了一种减少由衍生自血浆级分的药物制剂引起的不良事件的方法，其中所述方法包括使血浆级分与肝素或肝素样物质接触，从而降低至少一种活化丝氨酸蛋白酶的活性 血浆分数。

公开(公告)号：US20150150911A2

公开(公告)日：2015-06-04

申请号：US14116491

申请日：2012-05-14

申请人： Stefan Schulte ,  Uwe Kalina ,  Michael Moses ,  Annette Feussner

发明人： Stefan Schulte ,  Uwe Kalina ,  Michael Moses ,  Annette Feussner

IPC分类号： A61K35/16

CPC分类号： A61K35/16 ,  A61K31/727 ,  A61K38/385 ,  A61K38/57 ,  C12Y304/21008 ,  C12Y304/21027 ,  C12Y304/21038

摘要： The instant invention provides a method to reduce adverse events caused by a pharmaceutical preparation derived from a plasma fraction said plasma fraction comprising antithrombin III wherein the method comprises contacting the plasma fraction with heparin or a heparin-like substance thereby reducing the activity of at least one activated serine protease per ml of the plasma fraction.

摘要翻译： 本发明提供了一种减少由衍生自血浆级分的药物制剂引起的不良事件的方法，所述血浆级分包含抗凝血酶III，其中所述方法包括使血浆级分与肝素或肝素样物质接触，从而降低至少一种 每毫升血浆级分活化丝氨酸蛋白酶。

公开(公告)号：US20060079891A1

公开(公告)日：2006-04-13

申请号：US11232174

申请日：2005-09-21

申请人： Gene Arts ,  Gary Couture ,  Kristin Johnson ,  Michael Moses

发明人： Gene Arts ,  Gary Couture ,  Kristin Johnson ,  Michael Moses

IPC分类号： A61B18/14 ,  A61B17/32

CPC分类号： A61B18/1442 ,  A61B17/2812 ,  A61B17/32 ,  A61B17/3201 ,  A61B2018/00345 ,  A61B2018/00404 ,  A61B2018/00601 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/1457 ,  A61B2018/146

摘要： Open electrosurgical forceps for sealing tissue are provided which include first and second shaft portions pivotably associated with one another. Each shaft portion has a jaw member disposed at a distal end thereof. Each of the jaw members includes an electrically conductive sealing surface adapted to communicate electrosurgical energy through tissue held therebetween and a slot formed through the sealing surface thereof. The forceps includes a cutting mechanism operatively associated with the first and second jaw members. The cutting mechanism includes a cutting element disposed within the slot of the at least one jaw member, the cutting element being movable from a first position wherein the cutting element is retracted within the at least one jaw member and a second position in which the cutting element at least partially projects from a sealing surface of the at least one jaw member.

摘要翻译： 提供用于密封组织的打开的电外科钳，其包括彼此可枢转地相关联的第一和第二轴部。 每个轴部分具有设置在其远端处的钳口构件。 每个钳口构件包括导电密封表面，其适于将电外科能量通过其间保持的组织和通过其密封表面形成的狭槽来传递。 镊子包括与第一和第二钳口构件可操作地相关联的切割机构。 所述切割机构包括设置在所述至少一个钳口构件的槽内的切割元件，所述切割元件可从第一位置移动，其中所述切割元件缩回到所述至少一个夹爪构件内，以及第二位置，所述切割元件 至少部分地从所述至少一个钳口构件的密封表面突出。

公开(公告)号：US20050021025A1

公开(公告)日：2005-01-27

申请号：US10474168

申请日：2001-04-06

申请人： Steven Buysse ,  Michael Moses ,  David Schechter ,  Kristin Johnson ,  Philip Tetzlaff ,  Carolyn Mihaichuk

发明人： Steven Buysse ,  Michael Moses ,  David Schechter ,  Kristin Johnson ,  Philip Tetzlaff ,  Carolyn Mihaichuk

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B2017/2945 ,  A61B2018/00083 ,  A61B2018/0063 ,  A61B2018/1432 ,  A61B2018/1495

摘要： An electrode assembly for use in combination with an electrosurgical instrument having opposing end effectors and a handle for effecting movement of the end effectors relative to one another. The electrode assembly includes a housing having one portion which is removably engageable with the electrosurgical instrument and a pair of electrodes each having an electrically conductive sealing surface and an insulating substrate. The electrodes are removably engageable with the end effectors of the electrosurgical instrument such that the electrodes reside in opposing relation relative to one another. The dimensions of the insulating substrate are different from the dimensions of the electrically conductive sealing surface to reduce thermal spread to adjacent tissue structures.

摘要翻译： 一种用于与具有相对的末端执行器的电外科器械组合使用的电极组件和用于实现末端执行器相对于彼此运动的手柄。 电极组件包括具有可拆卸地与电外科器械接合的一部分的壳体和各自具有导电密封表面和绝缘基底的一对电极。 电极可移除地与电外科器械的末端执行器接合，使得电极相对于彼此处于相对关系。 绝缘基板的尺寸不同于导电密封表面的尺寸，以减少对相邻组织结构的热扩散。

公开(公告)号：US20050004568A1

公开(公告)日：2005-01-06

申请号：US10474273

申请日：2001-04-06

申请人： Kate Lawes ,  Steven Buysse ,  Sean Dycus ,  Kristin Johnson ,  Michael Moses ,  David Schechter ,  Philip Tetzlaff ,  Carolyn Mihaichuk

发明人： Kate Lawes ,  Steven Buysse ,  Sean Dycus ,  Kristin Johnson ,  Michael Moses ,  David Schechter ,  Philip Tetzlaff ,  Carolyn Mihaichuk

IPC分类号： A61B17/12 ,  A61B17/28 ,  A61B18/12 ,  A61B18/14

CPC分类号： A61B18/1442 ,  A61B18/14 ,  A61B18/1445 ,  A61B2017/2945 ,  A61B2018/00083 ,  A61B2018/00345 ,  A61B2018/00404 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/126 ,  A61B2018/1432 ,  A61B2018/146 ,  A61B2018/1495

摘要： An electrosurgical instrument which includes opposing end effectors and a handle for effecting movement of the end effectors relative to one another. The instrument includes a housing and a pair of electrodes. Each electode preferably includes an electrically conductive surface (e.g., which can be dimensioned for sealing, clamping and/or cutting) and an insulating substrate which is dimensioned to be engageable with the end effectors such that the electrodes reside in opposing relation relative to one another. The dimensions of the insulating substrate are different from the dimensions of the electrically conductive surface to reduce thermal spread to adjacent tissue structures. The insulating substrate is made from a material having a Comparative Tracking Index of about 300 volts to about 600 volts to reduce the incidence of flashover.

摘要翻译： 一种电外科器械，其包括相对的末端执行器和用于实现末端执行器相对于彼此运动的手柄。 仪器包括壳体和一对电极。 每个电极优选地包括导电表面（例如，其尺寸可以用于密封，夹紧和/或切割）以及绝缘基板，该绝缘基板的尺寸被设计成可与末端执行器接合，使得电极相对于彼此处于相对关系 。 绝缘基板的尺寸不同于导电表面的尺寸，以减少热传播到相邻的组织结构。 绝缘衬底由具有约300伏至约600伏特的比较跟踪指数的材料制成，以减少闪络的发生率。

公开(公告)号：US20060259036A1

公开(公告)日：2006-11-16

申请号：US11489319

申请日：2006-07-19

申请人： Philip Tetzlaff ,  James Cunningham ,  Michael Moses ,  Roger Smith ,  Kristin Johnson ,  Paul Romero

发明人： Philip Tetzlaff ,  James Cunningham ,  Michael Moses ,  Roger Smith ,  Kristin Johnson ,  Paul Romero

IPC分类号： A61B18/14

CPC分类号： A61B18/1442 ,  A61B17/29 ,  A61B18/1445 ,  A61B2017/2945 ,  A61B2018/1432 ,  A61B2018/145 ,  A61B2018/146 ,  A61B2018/1495 ,  A61B2090/034

摘要： A removable electrode assembly for use in combination with a forceps having opposing end effectors and a handle for effecting movement of the end effectors relative to one another. The electrode assembly includes a housing which is removably engageable with the forceps and a pair of electrodes which are attachable to a distal end of the housing. The electrodes are removably engageable with the end effectors of the forceps such that the electrodes reside in opposing relation relative to one another. The electrode assembly also includes a cover plate which is removably attachable to the housing and at least one stop member for controlling the distance between the opposing electrodes. The stop member is selectively engageable with the electrodes.

公开(公告)号：US20070255279A1

公开(公告)日：2007-11-01

申请号：US11800583

申请日：2007-05-07

申请人： Steven Buysse ,  Michael Moses ,  David Schechter ,  Kristin Johnson ,  Philip Tetzlaff ,  Carolyn Mihaichuk

发明人： Steven Buysse ,  Michael Moses ,  David Schechter ,  Kristin Johnson ,  Philip Tetzlaff ,  Carolyn Mihaichuk

IPC分类号： A61B18/18

CPC分类号： A61B18/1445 ,  A61B2017/00296 ,  A61B2017/2945 ,  A61B2018/0063 ,  A61B2018/1405 ,  A61B2018/1432

摘要： An electrode assembly for use in combination with an electrosurgical instrument having opposing end effectors and a handle for effecting movement of the end effectors relative to one another. The electrode assembly includes a housing having one portion which is removably engageable with the electrosurgical instrument and a pair of electrodes each having an electrically conductive sealing surface and an insulating substrate. The electrodes are removably engageable with the end effectors of the electrosurgical instrument such that the electrodes reside in opposing relation relative to one another. The dimensions of the insulating substrate are different from the dimensions of the electrically conductive sealing surface to reduce thermal spread to adjacent tissue structures.

摘要翻译： 一种用于与具有相对的末端执行器的电外科器械组合使用的电极组件和用于实现末端执行器相对于彼此运动的手柄。 电极组件包括具有可拆卸地与电外科器械接合的一部分的壳体和各自具有导电密封表面和绝缘基底的一对电极。 电极可移除地与电外科器械的末端执行器接合，使得电极相对于彼此处于相对关系。 绝缘基板的尺寸不同于导电密封表面的尺寸，以减少对相邻组织结构的热扩散。

公开(公告)号：US20060189981A1

公开(公告)日：2006-08-24

申请号：US11358180

申请日：2006-02-21

申请人： Sean Dycus ,  Gary Couture ,  Lap Nguyen ,  Kristin Johnson ,  Michael Moses

发明人： Sean Dycus ,  Gary Couture ,  Lap Nguyen ,  Kristin Johnson ,  Michael Moses

IPC分类号： A61B18/14

CPC分类号： A61B18/1445 ,  A61B2018/0013 ,  A61B2018/00345 ,  A61B2018/00404 ,  A61B2018/0063 ,  A61B2018/1412 ,  A61B2018/1455 ,  A61B2018/1861 ,  A61B2090/034

摘要： An endoscopic bipolar forceps for sealing and dividing tissue which includes an elongated shaft having opposing jaw members at a distal end thereof. The jaw members are movable relative to one another about a pivot from a first spaced position to a second closed position to grasp tissue. Each jaw member is adapted to couple to a generator for conducting energy to effect a seal. The forceps also includes a handle assembly and a longitudinally reciprocating knife assembly which is translatable to sever tissue. The knife assembly includes a bifurcated knife bar having two forks which ride about the pivot during translation of the knife. One or more non-conductive stop members are operatively associated with the jaw members to regulate the distance between the jaw members when closed.

公开(公告)号：US20060167452A1

公开(公告)日：2006-07-27

申请号：US11333165

申请日：2006-01-17

申请人： Michael Moses ,  Duane Kerr

发明人： Michael Moses ,  Duane Kerr

IPC分类号： A61B18/14 ,  A61B17/32

CPC分类号： A61B18/1442 ,  A61B17/3201 ,  A61B17/3211 ,  A61B2017/00504 ,  A61B2017/1225 ,  A61B2017/2945 ,  A61B2018/00404 ,  A61B2018/00601 ,  A61B2018/1432 ,  A61B2018/1455

摘要： A disposable open electrosurgical forceps for sealing tissue is disclosed in the present disclosure. The disposable open electrosurgical forceps comprise a pair of first and second shaft members containing a fiber reinforced thermoplastic blend material having fiber strands of at least 2 millimeters in length. Each shaft member includes a jaw member disposed at a distal end thereof which are movable from a first position in spaced relation relative to one another to at least one subsequent position wherein the jaw members cooperate to grasp tissue therebetween. Each of the jaw members also includes an electrically conductive sealing plate for communicating electrosurgical energy through tissue held therebetween. At least one of the jaw members includes a knife channel defined along a length thereof which is dimensioned to reciprocate a cutting mechanism therealong. An actuator is included for selectively advancing the cutting mechanism from a first position wherein the cutting mechanism is disposed proximal to tissue held between the jaw members to at least one subsequent position wherein the cutting mechanism is disposed distal to tissue held between the jaw members. The actuator includes a trigger which cooperates with a rack and pinion system to advance the cutting mechanism from the first to second positions through tissue held therebetween.

摘要翻译： 在本公开中公开了用于密封组织的一次性打开的电外科钳。 一次性打开的电外科钳包括一对第一和第二轴构件，其包含长度为至少2毫米的纤维束的纤维增强的热塑性共混材料。 每个轴构件包括设置在其远端处的钳口构件，其可以从第一位置相对于彼此间隔开地移动到至少一个随后的位置，其中钳口构件协作以在其间抓握组织。 每个钳口构件还包括用于通过保持在其间的组织传导电外科能量的导电密封板。 钳口构件中的至少一个包括沿着其长度限定的刀槽，其尺寸被设计成沿其往复运动切割机构。 包括致动器，用于从第一位置选择性地推进切割机构，其中切割机构设置在保持在夹爪构件之间的组织的近侧至少一个后续位置，其中切割机构设置在夹持在夹爪构件之间的组织的远侧。 致动器包括与齿条和小齿轮系统配合的扳机，以通过在其间保持的组织将切割机构从第一位置移动到第二位置。

公开(公告)号：US20050154387A1

公开(公告)日：2005-07-14

申请号：US10962116

申请日：2004-10-08

申请人： Michael Moses ,  Paul Romero ,  Kristin Johnson ,  Duane Kerr ,  Sean Dycus

发明人： Michael Moses ,  Paul Romero ,  Kristin Johnson ,  Duane Kerr ,  Sean Dycus

IPC分类号： A61B17/3201 ,  A61B17/12 ,  A61B17/125 ,  A61B17/28 ,  A61B18/00 ,  A61B18/12 ,  A61B18/14 ,  A61B18/18

CPC分类号： A61B17/2812 ,  A61B17/285 ,  A61B17/32 ,  A61B17/3211 ,  A61B18/1442 ,  A61B2017/2945 ,  A61B2018/00196 ,  A61B2018/00345 ,  A61B2018/00404 ,  A61B2018/00601 ,  A61B2018/00619 ,  A61B2018/0063 ,  A61B2018/00922 ,  A61B2018/00946 ,  A61B2018/1412 ,  A61B2018/1432 ,  A61B2018/1455

摘要： An open electrosurgical forceps for sealing tissue includes a pair of first and second shaft members each having a jaw member disposed at a distal end thereof. The jaw members are movable from a first position in spaced relation relative to one another to at least one subsequent position wherein the jaw members cooperate to grasp tissue therebetween. Each of the jaw members includes an electrically conductive sealing plate for communicating electrosurgical energy through tissue held therebetween. At least one of the jaw members includes a knife channel defined along a length thereof which is dimensioned to reciprocate a cutting blade therealong. An actuator is included which is operatively connected to one of the shaft members and selectively advances the cutting mechanism from a first position wherein the cutting blade is disposed proximal to tissue held between the jaw members to at least one subsequent position wherein the cutting blade is disposed distal to tissue held between the jaw members. The cutting blade is a generally hourglass-shaped flexible cutting blade having a notch disposed generally midway therealong which facilitates distal translation of the knife within the knife channel.

摘要翻译： 用于密封组织的开放的电外科钳包括一对第一和第二轴构件，每个第一和第二轴构件具有设置在其远端处的钳口构件。 钳口构件可以从相对于彼此间隔开的第一位置移动到至少一个随后的位置，其中钳口构件协作以抓住其间的组织。 每个钳口构件包括用于通过保持在其间的组织传导电外科能量的导电密封板。 钳口构件中的至少一个包括沿着其长度限定的刀槽，其尺寸被设计成使其上的切割刀片往复运动。 包括致动器，其可操作地连接到轴构件中的一个，并且选择性地将切割机构从第一位置前进，其中切割刀片设置在保持在夹爪构件之间的组织的近侧至少一个后续位置，其中切割刀片设置 远离组织夹持在钳口构件之间。 切割刀片是通常为沙漏形的柔性切割刀片，其具有通常沿着其中间设置的凹口，其有助于刀在刀具通道内的远端平移。