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    METHOD FOR THE PRODUCTION OF AN IMMUNOSTIMULATING MUCIN (MUC1)
    1.
    发明申请
    METHOD FOR THE PRODUCTION OF AN IMMUNOSTIMULATING MUCIN (MUC1) 有权
    生产免疫球蛋白（MUC1）的方法

    公开(公告)号：US20100273992A1

    公开(公告)日：2010-10-28

    申请号：US12818839

    申请日：2010-06-18

    申请人： Steffen GOLETZ ,  Uwe Karsten

    发明人： Steffen GOLETZ ,  Uwe Karsten

    IPC分类号： C07K14/435

    CPC分类号： C07K14/4727 ,  A61K38/1735 ,  A61K39/0005 ,  A61K45/06 ,  A61K2039/505 ,  C07K16/3092 ,  C07K16/44

    摘要： The present invention relates to a method for producing or identifying a MUC1 molecule which is able to generate an immune response in humans. The invention also relates to a method for producing or identifying a cell, cell lines or cell lysates containing a MUC1 molecule that is able to generate an immune response in humans. The invention further relates to methods for producing medicaments and diagnostic agents. Also disclosed is the use of the MUC1 molecules, cells or cell lysates obtained by means of the methods according to the invention for producing a medicament used for treating or preventing tumours. Further disclosed is a purified MUC1 molecule that can be obtained by means of the methods according to the invention and has an immunostimulating effect on humans. The invention additionally relates to the use of a MUC1 antibody for the production of a medicament used for treating or preventing tumours.

    摘要翻译： 本发明涉及能够在人体中产生免疫应答的产生或鉴定MUC1分子的方法。 本发明还涉及产生或鉴定含有能够在人体中产生免疫应答的MUC1分子的细胞，细胞系或细胞裂解物的方法。 本发明还涉及生产药物和诊断剂的方法。 还公开了通过根据本发明的方法获得的MUC1分子，细胞或细胞裂解物用于产生用于治疗或预防肿瘤的药物的用途。 进一步公开的是可以通过本发明的方法获得并且对人类具有免疫刺激作用的纯化的MUC1分子。 本发明还涉及MUC1抗体用于制备用于治疗或预防肿瘤的药物的用途。

    NATURAL MICROORGANISMS WHICH ARE NATURALLY CAPABLE OF BINDING TOXINS AND/OR TOXIN RECEPTORS
    2.
    发明申请
    NATURAL MICROORGANISMS WHICH ARE NATURALLY CAPABLE OF BINDING TOXINS AND/OR TOXIN RECEPTORS 审中-公开

    公开(公告)号：US20190257832A1

    公开(公告)日：2019-08-22

    申请号：US16318532

    申请日：2017-07-18

    申请人： Philippe ULSEMER ,  Steffen GOLETZ ,  Peter GOETZ

    发明人： Philippe ULSEMER ,  Steffen GOLETZ ,  Peter GOETZ

    IPC分类号： G01N33/569 ,  C12N1/16 ,  C12N1/20 ,  A61P1/00 ,  A61K35/74

    摘要： The present invention relates to means and method for isolating naturally-occurring microorganisms (non-pathogenic bacteria, yeasts or fungi) capable of binding toxins from microorganisms such as bacteria, viruses, fungi, yeasts, or protozoans and/or receptors for these toxins on the surface of mammalian cells, thereby making these receptors inaccessible for said toxins. The naturally-occurring microorganisms that are obtainable by the means and methods of the present invention can be used for adsorbing toxins from pathogenic microorganisms and/or blocking receptors for such toxins on the surface of mammalian cells. These toxin-receptor interactions are known to be critical for disease pathogenesis, making both the toxins and receptors a target for the naturally-occurring microorganisms of the present invention.