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公开(公告)号：US06958350B2
公开(公告)日：2005-10-25
申请号：US10468179
申请日：2002-02-18
IPC分类号： A61K31/4545 , A61P1/00 , A61P1/04 , A61P3/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/00 , A61P21/04 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , A61K31/454 , A61K31/4535
CPC分类号： C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The invention provides a compound of formula (I): wherein R1, R2, R3, R4, R5, N, X and Y are as defined in the specification, processes, for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions.
摘要翻译： 本发明提供式（I）化合物：其中R 1，R 2，R 3，R 4， R 5，N，X和Y如说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是用于治疗趋化因子受体相关疾病 和条件。
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2.发明申请Substituted piperidine compounds useful as modulators of chemokine receptor activity 审中-公开可用作趋化因子受体活性调节剂的取代哌啶化合物公开(公告)号：US20050250792A1
公开(公告)日：2005-11-10
申请号：US11081201
申请日：2005-03-16
申请人： Stephen Thom , Andrew Baxter , Nicholas Kindor , Thomas McInally , Brian Springthorpe , Matthew Perry , David Harden , Richard Evans , David Marriott
发明人： Stephen Thom , Andrew Baxter , Nicholas Kindor , Thomas McInally , Brian Springthorpe , Matthew Perry , David Harden , Richard Evans , David Marriott
IPC分类号： C07D473/34 , A61K31/4468 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/52 , A61P1/00 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/06 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D211/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D451/04 , C07D487/04 , C07D491/056 , C07D495/04 , C07D513/04 , A61K31/505 , A61K31/455
CPC分类号： C07D401/12 , C07D211/58 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention provides compounds of formula (I): wherein R1, R2, R3, R6, Z, Q, m, n, X1, X2, X3, X4 and T are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions.
摘要翻译： 本发明提供式（I）化合物：其中R 1，R 2，R 3，R 6， ，Z，Q，m，n，X 1，X 2，X 3，X 4和T 如本说明书中所定义，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是用于治疗趋化因子受体相关疾病和病症。
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3.发明授权Substituted piperidine compounds useful as modulators of chemokine receptor activity 失效可用作趋化因子受体活性调节剂的取代哌啶化合物公开(公告)号：US06903085B1
公开(公告)日：2005-06-07
申请号：US10069215
申请日：2000-08-18
申请人： Stephen Thom , Andrew Baxter , Nicholas Kindor , Thomas McInally , Brian Springthorpe , Matthew Perry , David Harden , Richard Evans , David Marriott
发明人： Stephen Thom , Andrew Baxter , Nicholas Kindor , Thomas McInally , Brian Springthorpe , Matthew Perry , David Harden , Richard Evans , David Marriott
IPC分类号： C07D473/34 , A61K31/4468 , A61K31/4525 , A61K31/453 , A61K31/4535 , A61K31/454 , A61K31/4545 , A61K31/46 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/519 , A61K31/52 , A61P1/00 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P17/14 , A61P19/00 , A61P19/02 , A61P19/08 , A61P25/00 , A61P25/06 , A61P29/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07D211/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D451/04 , C07D487/04 , C07D491/056 , C07D495/04 , C07D513/04 , A61K31/33 , A61K31/435 , A61K31/445 , C07D211/00 , C07D413/00
CPC分类号： C07D401/12 , C07D211/58 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12
摘要： The invention provides compounds of formula (I) wherein R1, R2, R3, R6, Z, Q, m, n, X1, X2, X3, X4 and T are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions
摘要翻译： 本发明提供式（I）化合物，其中R 1，R 2，R 3，R 6， Z，Q，m，n，X 1，X 2，X 3，X 4和T分别为 如本说明书中所定义的，其制备方法，含有它们的药物组合物及其在治疗中的用途，特别是用于治疗趋化因子受体相关疾病和病症
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4.发明申请Piperidine derivatives for the treatment of chemokine or h1 mediated disease state 审中-公开哌啶衍生物用于治疗趋化因子或h1介导的疾病状态公开(公告)号：US20060281726A1
公开(公告)日：2006-12-14
申请号：US10549868
申请日：2004-03-23
IPC分类号： C07D401/14 , C07D401/02 , A61K31/4545 , A61K31/5377 , A61K31/55 , A61K31/496 , C07D413/14
CPC分类号： C07D401/06 , C07D401/14
摘要： The present invention provides a compound of a formula (I), wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
摘要翻译： 本发明提供式（I）化合物，其中变量在本文中定义; 涉及制备这种化合物的方法; 以及这种化合物在治疗趋化因子（例如CCR3）或H1介导的疾病状态中的用途。
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公开(公告)号：US20090118513A1
公开(公告)日：2009-05-07
申请号：US12354439
申请日：2009-01-15
IPC分类号： C07D401/14 , C07D211/06
CPC分类号： C07D211/46
摘要： The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
摘要翻译： 本发明提供式（I）的化合物：其中变量在本文中定义; 涉及制备这种化合物的方法; 以及这种化合物在治疗趋化因子（例如CCR3）或H1介导的疾病状态中的用途。
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公开(公告)号：US07495013B2
公开(公告)日：2009-02-24
申请号：US10551493
申请日：2004-03-30
IPC分类号： A61K31/4545 , C07D401/06
CPC分类号： C07D211/46
摘要： The present invention relates to compounds of formula (I): The variables recited in formula (I) are defined in the specification. The present invention also relates to processes of preparing compounds of formula (I) and uses of such compounds for treating a chemokine (e.g., CCR3) or H1 mediated disease state.
摘要翻译： 本发明涉及式（I）的化合物：式（I）中记载的变量在本说明书中定义。 本发明还涉及制备式（I）化合物的方法及其用于治疗趋化因子（例如CCR3）或H1介导的疾病状态的用途。
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7.发明申请Piperidine Derivatives, Their Process for Preparation, Their Use as Therapeutic Agents and Pharmaceutical Compositions Containing Them 审中-公开哌啶衍生物，其制备方法，用作治疗剂和含有它们的药物组合物公开(公告)号：US20090023733A1
公开(公告)日：2009-01-22
申请号：US12281121
申请日：2007-03-06
IPC分类号： C07D211/58 , A61K31/445 , A61K31/454 , C07D401/12 , C07D417/12 , A61K31/47 , A61K31/501 , A61K31/502 , A61K31/497 , A61K31/5377 , C07D413/12 , A61K31/517 , A61K31/4545
CPC分类号： C07D211/58 , C07D401/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a compound of a formula (I): [Chemical formula should be inserted here. Please see paper copy] wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) mediated disease state.
摘要翻译： 本发明提供式（I）的化合物：[化学式应该在此插入。 请参见纸质文件]其中变量在本文中定义; 涉及制备这种化合物的方法; 以及这种化合物在治疗趋化因子（例如CCR3）介导的疾病状态中的用途。
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公开(公告)号：US20080275084A1
公开(公告)日：2008-11-06
申请号：US11915460
申请日：2006-05-24
申请人： Matthew Perry , Brian Springthorpe
发明人： Matthew Perry , Brian Springthorpe
IPC分类号： A61K31/4545 , C07D401/06
CPC分类号： C07D211/46
摘要： The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
摘要翻译： 本发明提供式（I）的化合物：其中变量在本文中定义; 涉及制备这种化合物的方法; 以及这种化合物在治疗趋化因子（例如CCR3）或H1介导的疾病状态中的用途。
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公开(公告)号：US20130023562A1
公开(公告)日：2013-01-24
申请号：US13560339
申请日：2012-07-27
IPC分类号： C07D211/46 , A61P11/00 , A61P11/06 , A61P19/02 , A61P25/28 , A61P17/06 , A61P17/00 , A61P27/02 , A61P1/04 , A61K31/4545 , A61P19/10
CPC分类号： C07C309/73 , C07D211/46
摘要： The present invention provides a compound of a formula (I): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) mediated disease state.
摘要翻译： 本发明提供式（I）的化合物：其中变量在本文中定义; 涉及制备这种化合物的方法; 以及这种化合物在治疗趋化因子（例如CCR3）介导的疾病状态中的用途。
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10.发明申请Piperidine Derivatives Useful as Modulators of Chemokine Receptor Activity 审中-公开哌啶衍生物可用作趋化因子受体活性的调节剂公开(公告)号：US20090069325A1
公开(公告)日：2009-03-12
申请号：US12267983
申请日：2008-11-10
IPC分类号： A61K31/5377 , C07D413/02 , A61P37/00
CPC分类号： C07D409/14 , C07D211/44 , C07D413/06 , C07D413/14
摘要： The present invention relates to the compounds of formula (I): in which: and the remaining variables are defined herein. The present invention also relates to a process for preparing such compounds and use of such compounds in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
摘要翻译： 本发明涉及式（I）化合物：其中：和其余变量在本文中定义。 本发明还涉及制备这些化合物的方法和这些化合物在治疗趋化因子（如CCR3）或H1介导的疾病状态中的用途。
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