公开(公告)号：US07041280B2

公开(公告)日：2006-05-09

申请号：US10187316

申请日：2002-06-27

申请人： Stephen Randall Holmes-Farley ,  W. Harry Mandeville, III ,  Pradeep K. Dhal ,  Chad Cori Huval ,  Xinhua Li ,  Steven Craig Polomoscanik

发明人： Stephen Randall Holmes-Farley ,  W. Harry Mandeville, III ,  Pradeep K. Dhal ,  Chad Cori Huval ,  Xinhua Li ,  Steven Craig Polomoscanik

IPC分类号： A61K31/80

CPC分类号： C08F8/42 ,  A61K31/74 ,  A61K31/785 ,  A61K47/58 ,  C08F8/44 ,  C08G65/331 ,  C08G73/0206 ,  C08G79/08 ,  C08F20/60 ,  C08F26/02

摘要： Disclosed are polymers comprising one or more phenyl boronate ester, boronamide or boronate thioester groups. The phenyl boronate ester, boronamide and boronate thioester groups are represented by one of the following structural formulas: Ar in Structural Formulas (I) and (II) is substituted or unsubstituted; and each Z is —O—, —NH— or —S— and is independently selected. Pharmaceutically acceptable salts of the polymer are also included. The aryl boronate ester, boronamide or boronate thioester can be cleaved to release the corresponding aryl boronic acid.Also disclosed are pharmaceutical compositions comprising the polymers of the present invention and a pharmaceutically acceptable carrier or diluent; and methods of treating a subject for obesity with the polymers of the present invention.