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    Amido-amine polymer compositions
    1.
    发明授权
    Amido-amine polymer compositions 有权
    酰胺 - 胺聚合物组合物

    公开(公告)号：US08163799B2

    公开(公告)日：2012-04-24

    申请号：US12448222

    申请日：2007-12-10

    Applicant: Pradeep K. Dhal ,  Stephen Randall Holmes-Farley ,  Chad C. Huval

    Inventor： Pradeep K. Dhal ,  Stephen Randall Holmes-Farley ,  Chad C. Huval

    IPC: A61K31/221 ,  A61K31/132 ,  A61P13/22

    CPC classification number: A61K31/785 ,  A61K31/165 ,  A61K31/23

    Abstract: Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.

    Abstract translation: 化合物，聚合物，交联聚合物和包含其的药物组合物可衍生自具有两个或多个胺反应性基团的多胺单体和多官能单体。 这些化合物，聚合物，交联聚合物和组合物可用于治疗高磷血症或从动物（包括人）的胃肠道中除去离子。

    Amine condensation polymers as phosphate sequestrants
    2.
    发明申请
    Amine condensation polymers as phosphate sequestrants 审中-公开
    胺缩合聚合物作为磷酸盐螯合剂

    公开(公告)号：US20100254935A1

    公开(公告)日：2010-10-07

    申请号：US12656945

    申请日：2010-02-19

    Applicant: Chad C. Huval ,  Stephen Randall Holmes-Farley ,  Pradeep K. Dhal

    Inventor： Chad C. Huval ,  Stephen Randall Holmes-Farley ,  Pradeep K. Dhal

    IPC: A61K31/785 ,  A61P39/00

    CPC classification number: A61K31/785 ,  C08G73/02 ,  C08G73/0206

    Abstract: Disclosed is a polymer or physiologically acceptable salt thereof. The polymer comprises a polymerized multifunctional amine monomer. The amine monomer comprises at least two amine groups and at least two acyclic nitrogen atoms that are connected through a —CH2CH2— group, provided that the amine monomer is not ethylenediamine or diethylenetriamine. The disclosed polymers can be used to bind anions in subject in need of such treatment.

    Abstract translation: 公开了一种聚合物或其生理上可接受的盐。 聚合物包含聚合的多官能胺单体。 胺单体包含至少两个胺基团和至少两个通过-CH 2 CH 2 - 基团连接的无环氮原子，条件是胺单体不是乙二胺或二亚乙基三胺。 所公开的聚合物可用于结合需要这种治疗的受试者中的阴离子。

    AMIDO-AMINE POLYMER COMPOSITIONS
    5.
    发明申请
    AMIDO-AMINE POLYMER COMPOSITIONS 有权
    AMIDO-AMINE聚合物组合物

    公开(公告)号：US20120237470A1

    公开(公告)日：2012-09-20

    申请号：US13417592

    申请日：2012-03-12

    Applicant: Pradeep K. Dhal ,  Stephen Randall Holmes-Farley ,  Chad C. Huval

    Inventor： Pradeep K. Dhal ,  Stephen Randall Holmes-Farley ,  Chad C. Huval

    IPC: A61K31/785 ,  A61P13/12 ,  A61P1/00

    CPC classification number: A61K31/785 ,  A61K31/165 ,  A61K31/23

    Abstract: Compounds, polymers, crosslinked polymers and pharmaceutical compositions comprising the same may be derived from multi-amine monomers and multi-functional monomers having two or more amine reactive groups. Such compounds, polymers, crosslinked polymers and compositions may be used to treat hyperphosphatemia or to remove ions from the gastrointestinal tract of animals, including humans.

    Abstract translation: 化合物，聚合物，交联聚合物和包含其的药物组合物可衍生自具有两个或多个胺反应性基团的多胺单体和多官能单体。 这些化合物，聚合物，交联聚合物和组合物可用于治疗高磷血症或从动物（包括人）的胃肠道中除去离子。

    SULFONE POLYMER COMPOSITIONS
    6.
    发明申请
    SULFONE POLYMER COMPOSITIONS 审中-公开
    SUFFONE聚合物组合物

    公开(公告)号：US20100196305A1

    公开(公告)日：2010-08-05

    申请号：US12449974

    申请日：2008-03-05

    Applicant: Pradeep K. Dhal ,  Stephen Randall Holmes-Farley ,  Chad C. Huval ,  Steven C. Polomoscanik

    Inventor： Pradeep K. Dhal ,  Stephen Randall Holmes-Farley ,  Chad C. Huval ,  Steven C. Polomoscanik

    IPC: A61K31/795 ,  A61P3/00

    CPC classification number: C08G75/20 ,  C08G65/24 ,  C08G73/0253

    Abstract: Sulfone-containing copolymers and copolymer networks and compositions including sulfone-containing copolymers and copolymer networks may be used to bind target ions, such as phosphorous-containing compounds in the gastrointestinal tract of animals. In some cases, sulfone-containing copolymers and copolymer networks may be derived from a multi-amine monomer and a multifunctional sulfonyl-containing monomer comprising two or more amine-reactive groups.

    Abstract translation: 包含砜的共聚物和共聚物网络以及包含含砜共聚物和共聚物网络的组合物可用于结合目标离子，例如动物胃肠道中的含磷化合物。 在一些情况下，含砜共聚物和共聚物网络可以衍生自多胺单体和包含两个或更多个胺反应性基团的多官能磺酰基单体。

    Poly(diallylamine)-based bile acid sequestrants
    7.
    发明授权
    Poly(diallylamine)-based bile acid sequestrants 有权
    聚（二烯丙基胺）为基础的胆汁酸多价螯合剂

    公开(公告)号：US07125547B2

    公开(公告)日：2006-10-24

    申请号：US10647665

    申请日：2003-08-25

    Applicant: Stephen Randall Holmes-Farley ,  Pradeep K. Dhal ,  John S. Petersen

    Inventor： Stephen Randall Holmes-Farley ,  Pradeep K. Dhal ,  John S. Petersen

    IPC: A61K31/787 ,  A61P3/06

    CPC classification number: B82Y5/00 ,  A61K31/785 ,  A61K31/787 ,  A61K31/795 ,  A61K47/6949 ,  C08G61/12 ,  Y10S514/824

    Abstract: The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3–C24-alkyl group, an aralkyl group or an aryl group.

    Abstract translation: 本发明涉及一种从患者中除去胆汁酸的方法和本方法中使用的某些聚合物。 该方法包括向患者施用治疗有效量的聚合物组合物的步骤，该聚合物组合物包括被疏水基团取代的聚（二烯丙基胺）聚合物。 疏水基团可以是取代或未取代的直链或支链C 3 -C 24 - 烷基，芳烷基或芳基。

    Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants
    8.
    发明授权
    Polymers containing spirobicyclic ammonium moieties as bile acid sequestrants 有权
    含有螺二环铵部分的聚合物作为胆汁酸螯合剂

    公开(公告)号：US06271264B1

    公开(公告)日：2001-08-07

    申请号：US09203319

    申请日：1998-12-01

    Applicant: Pradeep K. Dhal ,  Steven C. Polomoscanik

    Inventor： Pradeep K. Dhal ,  Steven C. Polomoscanik

    IPC: A61K3114

    CPC classification number: A61K31/787 ,  C08F220/04 ,  C08F220/06

    Abstract: The present invention relates to a method for sequestering bile acids in a patient and to particular polymers for use in the method. The method comprises administering a therapeutically effective amount of a spirobicyclic ammonium moiety-containing polymer composition to a mammal, such as a human, whereby bile acids are sequestered. The polymers of the invention comprise spirobicyclic ammonium moieties and optionally, further comprise a hydrophobic substituent, a quaternary ammonium-containing substituent or a combination thereof.

    Abstract translation: 本发明涉及一种用于隔离患者中胆汁酸的方法和用于该方法的特定聚合物。 该方法包括向哺乳动物（例如人）施用治疗有效量的含螺环二铵部分的聚合物组合物，由此螯合胆汁酸。 本发明的聚合物包含螺二环铵部分，任选地还包含疏水性取代基，含季铵盐的取代基或其组合。

    Poly(diallylamine)-based bile acid sequestrants
    9.
    发明授权
    Poly(diallylamine)-based bile acid sequestrants 失效
    聚（二烯丙基胺）为基础的胆汁酸多价螯合剂

    公开(公告)号：US06203785B1

    公开(公告)日：2001-03-20

    申请号：US08777408

    申请日：1996-12-30

    Applicant: Stephen Randall Holmes-Farley ,  Pradeep K. Dhal ,  John S. Petersen

    Inventor： Stephen Randall Holmes-Farley ,  Pradeep K. Dhal ,  John S. Petersen

    IPC: A61K31787

    CPC classification number: B82Y5/00 ,  A61K31/785 ,  A61K31/787 ,  A61K31/795 ,  A61K47/6949 ,  C08G61/12 ,  Y10S514/824

    Abstract: The present invention relates to a method for removing bile acids from a patient and certain polymers of use in the method. The method comprises the step of administering to the patient a therapeutically effective amount of a polymer composition which includes a a poly(diallylamine) polymer which is substituted with hydrophobic groups. The hydrophobic groups can be a substituted or unsubstituted, straight chain or branched C3-C24-alkyl group, an aralkyl group or an aryl group.

    Abstract translation: 本发明涉及一种从患者中除去胆汁酸的方法和本方法中使用的某些聚合物。 该方法包括向患者施用治疗有效量的聚合物组合物的步骤，该聚合物组合物包括被疏水基团取代的聚（二烯丙基胺）聚合物。 疏水基团可以是取代或未取代的直链或支链C 3 -C 24 - 烷基，芳烷基或芳基。

    1,3-oxazoline compounds useful as anionic initiators suitable for polymerization of vinyl polymers
    10.
    发明授权
    1,3-oxazoline compounds useful as anionic initiators suitable for polymerization of vinyl polymers 失效
    可用作适合乙烯基聚合物聚合的阴离子引发剂的1,3-恶唑啉化合物

    公开(公告)号：US5266702A

    公开(公告)日：1993-11-30

    申请号：US585683

    申请日：1990-09-19

    Applicant: Durairaj Bhaskaran ,  Pradeep K. Dhal ,  Sanjay P. Kashikar ,  Ratnaprabha S. Khisti ,  Babanrao M. Shinde ,  Swaminathan Sivaram

    Inventor： Durairaj Bhaskaran ,  Pradeep K. Dhal ,  Sanjay P. Kashikar ,  Ratnaprabha S. Khisti ,  Babanrao M. Shinde ,  Swaminathan Sivaram

    IPC: C07D263/32

    CPC classification number: C07D263/32

    Abstract: Disclosed are reactive anionic initiators of the general formula [ArCHR.sub.1 R.sub.2 N(R.sub.3 R.sub.4 R.sub.5 R.sub.6 ] wherein Ar=phenyl, substituted phenyl, or a heterocyclic compound, R.sub.1 =R.sub.2 =H, ester, cyano, alkyl, aryl, 1,3-oxazoline, N,N-dimethyl amide and other similar alpha activating groups, or combination of them, or one of R.sub.1 or R.sub.2 together with Ar, where Ar is a phenyl or substituted phenyl, is a nitrogen atom containing heterocyclic compound and the other being a nitrile group, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 may be same or different and represent substituted alkyl, cycloalkyl, arylalkyl or aryl or to of the R.sub.3, R.sub.4, R.sub.5 and R.sub.6 together with nitrogen atom form a heterocycle with the condition that the sum of all carbon atoms of all R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is from 12 to 50 and no more than one of the R.sub.3, R.sub.4, R.sub.5 and R.sub.6 is an aryl derivative. The initiators which are in the form of solids or liquids are insoluble and can be incorporated which enable the synthesis of a wide range of polymers with functional groups. These initiators are useful for polymerizing very reactive vinyl monomers such as nitrile bearing vinyl compounds.

    Abstract translation: 公开了通式[ArCHR1R2N（R3R4R5R6）其中Ar =苯基，取代的苯基或杂环化合物，R1 = R2 = H，酯，氰基，烷基，芳基，1,3-恶唑啉，N，N 二甲基酰胺和其它类似的α活化基团，或它们的组合，或其中Ar为苯基或取代的苯基的R 1或R 2与Ar一起为氮原子的杂环化合物，另一个为腈基，R 3 ，R 4，R 5和R 6可以相同或不同，表示取代的烷基，环烷基，芳基烷基或芳基或R3，R4，R5和R6与氮原子一起形成杂环，条件是所有碳原子的总和 所有R 3，R 4，R 5和R 6为12至50，并且不超过一个R 3，R 4，R 5和R 6为芳基衍生物。固体或液体形式的引发剂是不溶的， 使得能够合成具有官能团的多种聚合物。这些引发剂a 可用于聚合非常活泼的乙烯基单体如腈基乙烯基化合物。

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