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    Hose Reel Cart With Multi-Position Crank Handle
    1.
    发明申请
    Hose Reel Cart With Multi-Position Crank Handle 有权
    软管卷轴车多功能手柄

    公开(公告)号：US20100155520A1

    公开(公告)日：2010-06-24

    申请号：US12341827

    申请日：2008-12-22

    申请人： Stephen Whitehead ,  Michael Thuma ,  Michael Uffner ,  Matthew McKimmy ,  Michael R. Vogler

    发明人： Stephen Whitehead ,  Michael Thuma ,  Michael Uffner ,  Matthew McKimmy ,  Michael R. Vogler

    IPC分类号： B65H75/44 ,  B65H75/38 ,  B65H75/30

    CPC分类号： B65H75/40 ,  B65H75/4407 ,  B65H75/4465 ,  B65H75/4471 ,  B65H75/4492 ,  B65H2402/412 ,  B65H2701/33 ,  Y10T137/6954

    摘要： The present invention relates to hose reel carts for handling and storage of flexible hoses, such as garden or air hoses. The hose reel cart is primarily constructed of plastic components having a centrally rotatable spool for winding of the flexible hose, a frame for supporting the spool and a multi-position crank arm assembly allowing the consumer to place the crank handle in a lowered position or a raised position. The crank remotely drives the spool, for winding the hose, through a series of gears located within the crank arm assembly. The device may further include a reciprocating guide assembly that operates during rotation of the spool to rewind the hose into a compact configuration.

    摘要翻译： 本发明涉及用于处理和储存诸如花园或空气软管的柔性软管的软管卷轴车。 软管卷盘车主要由塑料部件构成，该塑料部件具有用于缠绕柔性软管的可中心旋转的卷轴，用于支撑卷轴的框架和多位置的曲柄臂组件，其允许消费者将曲柄手柄放置在降低的位置或 提高职位 曲柄通过位于曲柄臂组件内的一系列齿轮远程地驱动滑阀，用于卷绕软管。 该装置可以进一步包括往复式导向组件，该往复导向组件在卷轴的旋转期间操作以将软管重新卷成紧凑的构造。

    Hose reel cart with multi-position crank handle
    2.
    发明授权
    Hose reel cart with multi-position crank handle 有权
    带多功能手柄的软管卷盘车

    公开(公告)号：US07959101B2

    公开(公告)日：2011-06-14

    申请号：US12341827

    申请日：2008-12-22

    申请人： Stephen Whitehead ,  Michael Thuma ,  Michael Uffner ,  Matthew McKimmy ,  Michael R. Vogler

    发明人： Stephen Whitehead ,  Michael Thuma ,  Michael Uffner ,  Matthew McKimmy ,  Michael R. Vogler

    IPC分类号： B65H75/30

    CPC分类号： B65H75/40 ,  B65H75/4407 ,  B65H75/4465 ,  B65H75/4471 ,  B65H75/4492 ,  B65H2402/412 ,  B65H2701/33 ,  Y10T137/6954

    摘要： The present invention relates to hose reel carts for handling and storage of flexible hoses, such as garden or air hoses. The hose reel cart is primarily constructed of plastic components having a centrally rotatable spool for winding of the flexible hose, a frame for supporting the spool and a multi-position crank arm assembly allowing the consumer to place the crank handle in a lowered position or a raised position. The crank remotely drives the spool, for winding the hose, through a series of gears located within the crank arm assembly. The device may further include a reciprocating guide assembly that operates during rotation of the spool to rewind the hose into a compact configuration.

    摘要翻译： 本发明涉及用于处理和储存诸如花园或空气软管的柔性软管的软管卷轴车。 软管卷盘车主要由塑料部件构成，该塑料部件具有用于缠绕柔性软管的可中心旋转的卷轴，用于支撑卷轴的框架和多位置的曲柄臂组件，其允许消费者将曲柄手柄放置在降低的位置或 提高职位 曲柄通过位于曲柄臂组件内的一系列齿轮远程地驱动滑阀，用于卷绕软管。 该装置可以进一步包括往复式导向组件，该往复导向组件在卷轴的旋转期间操作以将软管重新卷成紧凑的构造。

    Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules
    10.
    发明申请
    Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules 失效
    表达免疫调节分子的重组呼吸道合胞病毒的生产

    公开(公告)号：US20050147622A1

    公开(公告)日：2005-07-07

    申请号：US10754895

    申请日：2004-01-08

    申请人： Peter Collins ,  Alexander Bukreyev ,  Brian Murphy ,  Stephen Whitehead

    发明人： Peter Collins ,  Alexander Bukreyev ,  Brian Murphy ,  Stephen Whitehead

    IPC分类号： A61K39/00 ,  A61K48/00 ,  C07K14/135 ,  C07K14/54 ,  C12N7/04 ,  C12N15/86 ,  A61K39/12 ,  A61K39/155 ,  C12N7/00

    CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K48/00 ,  A61K2039/5254 ,  C07K14/54 ,  C07K2319/00 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18522 ,  C12N2760/18543 ,  C12N2760/18561 ,  C12N2840/20

    摘要： Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably a cytokine. Introduction of the cytokine increase, decrease, or otherwise enhances aspects of viral biology and/or host immune responses to RSV to facilitate vaccine use of the virus. Cytokines for use within the invention include but are not limited to interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL6), or interleukin 18 (IL-18), tumor necrosis factor (TNF) alpha, interferon gamma (IFN), and granulocyte-macrophage colony stimulating factor (GM-CSF). The polynucleotide or immune modulatory molecule is preferably added or substituted into the recombinant viral genome or antigenome, typically at an intergenic or other non-coding site, as a separate gene but may be otherwise expressed, for example as a fusion protein.

    摘要翻译： 提供重组呼吸道合胞病毒（RSV），其表达一种或多种免疫调节分子。 通过添加或取代编码免疫调节分子的多核苷酸序列来修饰重组病毒，所述多核苷酸序列优选是细胞因子。 引入细胞因子增加，减少或以其他方式增强病毒生物学和/或宿主对RSV的免疫应答的方面以促进病毒的疫苗使用。 本发明中使用的细胞因子包括但不限于白介素2（IL-2），白细胞介素4（IL-4），白介素5（IL-5），白介素6（IL6）或白细胞介素18（IL-18） ，肿瘤坏死因子（TNF）α，干扰素γ（IFN）和粒细胞巨噬细胞集落刺激因子（GM-CSF）。 多核苷酸或免疫调节分子优选地作为单独的基因加入或取代到重组病毒基因组或反向原核基因组中，通常在基因间或其他非编码位点，但可另外表达为例如融合蛋白。