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公开(公告)号：US09447047B2
公开(公告)日：2016-09-20
申请号：US14421757
申请日：2013-03-14
申请人： Sergei Nekhai , Alexander Bukreyev
发明人： Sergei Nekhai , Alexander Bukreyev
IPC分类号： A61K31/47 , C07D219/04 , A61K31/473 , C07D221/16 , C07D409/06 , C07D417/12
CPC分类号： C07D219/04 , A61K31/473 , C07D221/16 , C07D409/06 , C07D417/12
摘要： Inhibitors of protein phosphatase-1 (PP-1) and their use in a method for the treatment or prevention of viral infections caused by HIV or ebola virus are disclosed. Inhibitors of protein phosphatase-1 in effective amounts have been shown to slow down viral replication upon contacting ebola virus or cells containing the ebola virus.
摘要翻译： 公开了蛋白质磷酸酶-1（PP-1）的抑制剂及其在治疗或预防HIV或埃博拉病毒引起的病毒感染的方法中的用途。 有迹象的蛋白磷酸酶-1的抑制剂已被证明可减缓接触埃博拉病毒或含有埃博拉病毒的细胞时的病毒复制。
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2.发明申请Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules 审中-公开表达免疫调节分子的重组呼吸道合胞病毒的生产公开(公告)号：US20050220767A1
公开(公告)日：2005-10-06
申请号：US10917984
申请日：2004-08-11
IPC分类号： C12N15/09 , A61K9/12 , A61K35/76 , A61K39/00 , A61K39/155 , A61K48/00 , A61P11/00 , A61P11/06 , A61P31/14 , A61P37/04 , C07K14/54 , C12N7/00 , C12N7/04 , C12N15/86 , A61K39/12
CPC分类号： C07K14/54 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N15/86 , C12N2760/18543 , C12N2840/20
摘要： Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably a cytokine. Introduction of the cytokine increase, decrease, or otherwise enhances aspects of viral biology and/or host immune responses to RSV to facilitate vaccine use of the virus. Cytokines for use within the invention include but are not limited to interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6), or interleukin 18 (IL-18), tumor necrosis factor (TNF) alpha, interferon gamma (IFN), and granulocyte-macrophage colony stimulating factor (GM-CSF). The polynucleotide or immune modulatory molecule is preferably added or substituted into the recombinant viral genome or antigenome, typically at an intergenic or other non-coding site, as a separate gene but may be otherwise expressed, for example as a fusion protein.
摘要翻译： 提供重组呼吸道合胞病毒（RSV），其表达一种或多种免疫调节分子。 通过添加或取代编码免疫调节分子的多核苷酸序列来修饰重组病毒，所述多核苷酸序列优选是细胞因子。 引入细胞因子增加，减少或以其他方式增强病毒生物学和/或宿主对RSV的免疫应答的方面以促进病毒的疫苗使用。 用于本发明的细胞因子包括但不限于白介素2（IL-2），白细胞介素4（IL-4），白细胞介素5（IL-5），白介素6（IL-6）或白细胞介素18（IL- 18），肿瘤坏死因子（TNF）α，干扰素γ（IFN）和粒细胞巨噬细胞集落刺激因子（GM-CSF）。 多核苷酸或免疫调节分子优选地作为单独的基因加入或取代到重组病毒基因组或反向原核基因组中，通常在基因间或其他非编码位点，但可另外表达为例如融合蛋白。
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3.发明授权Polynucleotides encoding recombinant respiratory syncytial viruses expressing immune modulatory molecules 失效编码表达免疫调节分子的重组呼吸道合胞病毒的多核苷酸公开(公告)号：US07465794B2
公开(公告)日：2008-12-16
申请号：US10754895
申请日：2004-01-08
IPC分类号： C07H21/04 , C12P21/00 , A61K39/12 , A61K39/155
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , A61K2039/5254 , C07K14/54 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably a cytokine. Introduction of the cytokine increase, decrease, or otherwise enhances aspects of viral biology and/or host immune responses to RSV to facilitate vaccine use of the virus. Cytokines for use within the invention include but are not limited to interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL6), or interleukin 18 (IL-18), tumor necrosis factor (TNF) alpha, interferon gamma (IFN), and granulocyte-macrophage colony stimulating factor (GM-CSF). The polynucleotide or immune modulatory molecule is preferably added or substituted into the recombinant viral genome or antigenome, typically at an intergenic or other non-coding site, as a separate gene but may be otherwise expressed, for example as a fusion protein.
摘要翻译： 提供重组呼吸道合胞病毒（RSV），其表达一种或多种免疫调节分子。 通过添加或取代编码免疫调节分子的多核苷酸序列来修饰重组病毒，所述多核苷酸序列优选是细胞因子。 引入细胞因子增加，减少或以其他方式增强病毒生物学和/或宿主对RSV的免疫应答的方面以促进病毒的疫苗使用。 本发明中使用的细胞因子包括但不限于白介素2（IL-2），白细胞介素4（IL-4），白介素5（IL-5），白介素6（IL6）或白细胞介素18（IL-18） ，肿瘤坏死因子（TNF）α，干扰素γ（IFN）和粒细胞巨噬细胞集落刺激因子（GM-CSF）。 多核苷酸或免疫调节分子优选地作为单独的基因加入或取代到重组病毒基因组或反向原核基因组中，通常在基因间或其他非编码位点，但可另外表达为例如融合蛋白。
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4.发明申请Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules 失效表达免疫调节分子的重组呼吸道合胞病毒的生产公开(公告)号：US20050147622A1
公开(公告)日：2005-07-07
申请号：US10754895
申请日：2004-01-08
IPC分类号： A61K39/00 , A61K48/00 , C07K14/135 , C07K14/54 , C12N7/04 , C12N15/86 , A61K39/12 , A61K39/155 , C12N7/00
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , A61K2039/5254 , C07K14/54 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably a cytokine. Introduction of the cytokine increase, decrease, or otherwise enhances aspects of viral biology and/or host immune responses to RSV to facilitate vaccine use of the virus. Cytokines for use within the invention include but are not limited to interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL6), or interleukin 18 (IL-18), tumor necrosis factor (TNF) alpha, interferon gamma (IFN), and granulocyte-macrophage colony stimulating factor (GM-CSF). The polynucleotide or immune modulatory molecule is preferably added or substituted into the recombinant viral genome or antigenome, typically at an intergenic or other non-coding site, as a separate gene but may be otherwise expressed, for example as a fusion protein.
摘要翻译： 提供重组呼吸道合胞病毒（RSV），其表达一种或多种免疫调节分子。 通过添加或取代编码免疫调节分子的多核苷酸序列来修饰重组病毒，所述多核苷酸序列优选是细胞因子。 引入细胞因子增加，减少或以其他方式增强病毒生物学和/或宿主对RSV的免疫应答的方面以促进病毒的疫苗使用。 本发明中使用的细胞因子包括但不限于白介素2（IL-2），白细胞介素4（IL-4），白介素5（IL-5），白介素6（IL6）或白细胞介素18（IL-18） ，肿瘤坏死因子（TNF）α，干扰素γ（IFN）和粒细胞巨噬细胞集落刺激因子（GM-CSF）。 多核苷酸或免疫调节分子优选地作为单独的基因加入或取代到重组病毒基因组或反向原核基因组中，通常在基因间或其他非编码位点，但可另外表达为例如融合蛋白。
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5.发明申请Production of attenuated respiratory syncytial virus vaccines from cloned nucleotide sequences 有权从克隆的核苷酸序列产生减毒呼吸道合胞病毒疫苗公开(公告)号：US20060159703A1
公开(公告)日：2006-07-20
申请号：US10934003
申请日：2004-09-02
申请人： Brian Murphy , Peter Collins , Stephen Whitehead , Alexander Bukreyev , Katalin Juhasz , Michael Teng
发明人： Brian Murphy , Peter Collins , Stephen Whitehead , Alexander Bukreyev , Katalin Juhasz , Michael Teng
IPC分类号： A61K39/155 , C12N7/00 , C07K14/115
CPC分类号： C07K14/005 , A61K39/00 , C12N7/00 , C12N2760/18522 , C12N2760/18561
摘要： Attenuated respiratory syncytial virus (RSV) and vaccine compositions thereof are produced by introducing specific mutations associated with attenuating phenotypes into wild-type or RSV which is incompletely attenuated by cold-passage or introduction of mutations which produce virus having a temperature sensitive (ts) or cold adapted (ca) phenotype. Alternatively, recombinant RSV and vaccine compositions thereof incorporate attenuating and other mutations specifying desired structural and or phenotypic characteristics in an infectious RSV. Recombinant RSV incorporate desired mutations specified by insertion, deletion, substitution or rearrangement of a selected nucleotide sequence, gene, or gene segment in an infectious RSV clone. The immune system of an individual is stimulated to induce protection against natural RSV infection, or multivalently against infection by RSV and another pathogen, such as PIV, by administration of attenuated, biologically derived or recombinant RSV.
摘要翻译： 减毒的呼吸道合胞病毒（RSV）及其疫苗组合物通过将与将减毒表型相关的特异性突变引入野生型或RSV，通过冷通道或引入产生具有温度敏感性（ts）或 冷适应（ca）表型。 或者，重组RSV及其疫苗组合物结合了在感染性RSV中指定所需结构和/或表型特征的减毒和其它突变。 重组RSV包含通过在感染性RSV克隆中选择的核苷酸序列，基因或基因片段的插入，缺失，取代或重排而指定的所需突变。 通过施用减毒的，生物衍生的或重组的RSV，刺激个体的免疫系统以诱导针对天然RSV感染的保护，或多重抗RSV和另一种病原体如PIV的感染。
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6.发明授权Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules 失效表达免疫调节分子的重组呼吸道合胞病毒的生产公开(公告)号：US06699476B1
公开(公告)日：2004-03-02
申请号：US09614285
申请日：2000-07-12
IPC分类号： A61K3912
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , A61K2039/5254 , C07K14/54 , C07K2319/00 , C12N7/00 , C12N15/86 , C12N2760/18522 , C12N2760/18543 , C12N2760/18561 , C12N2840/20
摘要： Recombinant respiratory syncytial virus (RSV) are provided which express one or more immune modulatory molecules. The recombinant virus is modified by addition or substitution of a polynucleotide sequence encoding the immune modulatory molecule, which is preferably a cytokine. Introduction of the cytokine increase, decrease, or otherwise enhances aspects of viral biology and/or host immune responses to RSV to facilitate vaccine use of the virus. Cytokines for use within the invention include but are not limited to interleukin 2 (IL-2), interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL6), or interleukin 18 (IL-18), tumor necrosis factor (TNF) alpha, interferon gamma (IFN), and granulocyte-macrophage colony stimulating factor (GM-CSF). The polynucleotide or immune modulatory molecule is preferably added or substituted into the recombinant viral genome or antigenome, typically at an intergenic or other non-coding site, as a separate gene but may be otherwise expressed, for example as a fusion protein.
摘要翻译： 提供重组呼吸道合胞病毒（RSV），其表达一种或多种免疫调节分子。 通过添加或取代编码免疫调节分子的多核苷酸序列来修饰重组病毒，所述多核苷酸序列优选是细胞因子。 引入细胞因子增加，减少或以其他方式增强病毒生物学和/或宿主对RSV的免疫应答的方面以促进病毒的疫苗使用。 本发明中使用的细胞因子包括但不限于白介素2（IL-2），白细胞介素4（IL-4），白介素5（IL-5），白介素6（IL6）或白细胞介素18（IL-18） ，肿瘤坏死因子（TNF）α，干扰素γ（IFN）和粒细胞巨噬细胞集落刺激因子（GM-CSF）。 多核苷酸或免疫调节分子优选地作为单独的基因加入或取代到重组病毒基因组或反向原核基因组中，通常在基因间或其他非编码位点，但可另外表达为例如融合蛋白。
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