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公开(公告)号:US07842291B1
公开(公告)日:2010-11-30
申请号:US11802321
申请日:2007-05-22
申请人: Steve Ruben , Paul A. Moore , Tao He , Candy N. Lee , Karen Van Orden , Charles E. Birse , Mehdi Mesri , Elizabeth G. Joseloff
发明人: Steve Ruben , Paul A. Moore , Tao He , Candy N. Lee , Karen Van Orden , Charles E. Birse , Mehdi Mesri , Elizabeth G. Joseloff
IPC分类号: A16K39/395
CPC分类号: C07K16/3076 , A61K38/00 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K14/70546 , C07K14/70596 , C07K16/18 , C07K16/2839 , C07K16/2896 , C07K16/30 , C07K16/303 , C07K16/40 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C12N9/18 , C12N9/6424 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/158 , C12Y301/01 , C12Y304/21 , C12Y304/21109 , G01N33/57488 , G01N33/57492
摘要: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
摘要翻译: 提供用于评估,治疗和预防使用癌症相关靶(CAT)的疾病,特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT(例如拮抗剂或激动剂)如抗体,蛋白质,小分子化合物和核酸试剂(例如RNAi和反义试剂)的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法,以及通过这些筛选方法鉴定的试剂。
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公开(公告)号:US08486392B2
公开(公告)日:2013-07-16
申请号:US12901254
申请日:2010-10-08
申请人: Steve Ruben , Paul Moore , Tao He , Candy N. Lee , Karen Van Orden
发明人: Steve Ruben , Paul Moore , Tao He , Candy N. Lee , Karen Van Orden
IPC分类号: A61K39/395
CPC分类号: C07K16/3076 , A61K38/00 , A61K2039/505 , C07K14/4748 , C07K14/705 , C07K14/70546 , C07K14/70596 , C07K16/18 , C07K16/2839 , C07K16/2896 , C07K16/30 , C07K16/303 , C07K16/40 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/732 , C07K2317/734 , C12N9/18 , C12N9/6424 , C12N15/113 , C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/30 , C12Q1/6886 , C12Q2600/158 , C12Y301/01 , C12Y304/21 , C12Y304/21109 , G01N33/57488 , G01N33/57492
摘要: Methods and compositions are provided for assessing, treating, and preventing diseases, especially cancer, using cancer-associated targets (CAT). Methods and compositions are also provided for determining or predicting the effectiveness of a treatment for these diseases or for selecting a treatment, using CAT. Methods and compositions are further provided for modulating cell function using CAT. Also provided are compositions that modulate CAT (e.g., antagonists or agonists), such as antibodies, proteins, small molecule compounds, and nucleic acid agents (e.g., RNAi and antisense agents), as well as pharmaceutical compositions thereof. Further provided are methods of screening for agents that modulate CAT, and agents identified by these screening methods.
摘要翻译: 提供用于评估,治疗和预防使用癌症相关靶(CAT)的疾病,特别是癌症的方法和组合物。 还提供了用于确定或预测这些疾病的治疗或使用CAT选择治疗的有效性的方法和组合物。 还提供了使用CAT调节细胞功能的方法和组合物。 还提供了调节CAT(例如拮抗剂或激动剂)如抗体,蛋白质,小分子化合物和核酸试剂(例如RNAi和反义试剂)的组合物及其药物组合物。 进一步提供了筛选调节CAT的试剂的方法,以及通过这些筛选方法鉴定的试剂。
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公开(公告)号:US08110373B2
公开(公告)日:2012-02-07
申请号:US12504826
申请日:2009-07-17
申请人: Steve Ruben , Candy N. Lee , Bruno Domon
发明人: Steve Ruben , Candy N. Lee , Bruno Domon
IPC分类号: G01N33/574
CPC分类号: G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
摘要: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
摘要翻译: 提供了与健康细胞相比,用于诊断和治疗与疾病细胞中癌症相关靶(CAT)不同表达相关的疾病,特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂,以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。
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公开(公告)号:US07582441B1
公开(公告)日:2009-09-01
申请号:US11635029
申请日:2006-12-07
申请人: Steve Ruben , Candy N. Lee , Bruno Domon
发明人: Steve Ruben , Candy N. Lee , Bruno Domon
IPC分类号: G01N33/574 , C07K7/00
CPC分类号: G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
摘要: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
摘要翻译: 提供了与健康细胞相比,用于诊断和治疗与疾病细胞中癌症相关靶(CAT)不同表达相关的疾病,特别是癌症的方法和组合物。 还提供了CAT的拮抗剂和激动剂,以及用于筛选在体内或体外调节CAT水平或活性的药剂的方法。
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公开(公告)号:US08334106B2
公开(公告)日:2012-12-18
申请号:US13339833
申请日:2011-12-29
申请人: Steve Ruben , Candy N. Lee , Bruno Domon
发明人: Steve Ruben , Candy N. Lee , Bruno Domon
IPC分类号: G01N33/574
CPC分类号: G01N33/57484 , A61K38/00 , A61K47/6843 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C12N15/113 , C12N2310/14 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136 , G01N33/574 , G01N33/57423 , G01N33/6893 , G01N2500/10 , Y10T436/143333
摘要: Methods and compositions for diagnosing and treating diseases, particularly cancer, associated with differential expression of cancer-associated targets (CAT) in disease cells compared to healthy cells are provided. Also provided are antagonists and agonists of CAT, and methods for screening agents that modulate CAT level or activity in vivo or in vitro.
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