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    Compounds and methods for the diagnosis and treatment of B. microti infection
    1.
    发明授权
    Compounds and methods for the diagnosis and treatment of B. microti infection 有权
    用于诊断和治疗微生物感染的化合物和方法

    公开(公告)号：US06451315B1

    公开(公告)日：2002-09-17

    申请号：US09528784

    申请日：2000-03-17

    申请人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Paul R. Sleath ,  Patricia D. McNeill

    发明人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Paul R. Sleath ,  Patricia D. McNeill

    IPC分类号： A61K39002

    CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/51 ,  C07K2319/00 ,  Y10S530/822

    摘要： Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen, DNA sequences encoding such polypeptides, and fusion proteins comprising such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences, fusion proteins or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences, fusion proteins or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

    摘要翻译： 公开了用于诊断和治疗微生物感染的化合物和方法。 提供的化合物包括含有微生物抗原的至少一个抗原部分的多肽，编码这种多肽的DNA序列和包含这些多肽的融合蛋白。 还提供了这样的抗原的抗原表位以及包含这种多肽，DNA序列，融合蛋白或抗原表位的药物组合物和疫苗。 含有此类多肽，DNA序列，融合蛋白或抗原表位的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的微生物感染。 还提供了针对这种多肽和抗原表位的抗体。

    Compounds and methods for the diagnosis and treatment of Ehrlichia infection
    5.
    发明授权
    Compounds and methods for the diagnosis and treatment of Ehrlichia infection 有权
    用于诊断和治疗艾滋病感染的化合物和方法

    公开(公告)号：US06277381B1

    公开(公告)日：2001-08-21

    申请号：US09295028

    申请日：1999-04-20

    申请人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Patricia D. McNeill

    发明人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Patricia D. McNeill

    IPC分类号： A61K3902

    CPC分类号： C07K14/29 ,  A61K38/00 ,  C07K2319/00 ,  Y02A50/401 ,  Y02A50/402

    摘要： Compounds and methods for the diagnosis and treatment of Ehrlichia infection, in particular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions an vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containing such polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biologiacal samples. Antibodies directed against such polypeptides are also provided.

    摘要翻译： 公开了用于诊断和治疗埃里巴病毒感染，特别是人粒细胞性肾病的化合物和方法。 提供的化合物包括含有至少一种抗原部分的埃里希抗原的多肽和编码这种多肽的DNA序列。 药物组合物还提供了包含这种多肽或DNA序列的疫苗。 含有此类多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的埃氏体感染。 还提供了针对这种多肽的抗体。

    Compounds and methods for the diagnosis and treatment of ehrlichia infection
    6.
    发明授权
    Compounds and methods for the diagnosis and treatment of ehrlichia infection 有权
    用于诊断和治疗嗜热菌感染的化合物和方法

    公开(公告)号：US06673356B1

    公开(公告)日：2004-01-06

    申请号：US09693542

    申请日：2000-10-20

    申请人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Patricia D. McNeill

    发明人： Steven G. Reed ,  Michael J. Lodes ,  Raymond L. Houghton ,  Patricia D. McNeill

    IPC分类号： A61K3902

    CPC分类号： C07K14/29 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/53 ,  C07K2319/00 ,  Y02A50/403

    摘要： Compounds and methods for the diagnosis and treatment of Ehrlichia infection, inparticular human granulocytic ehrlichiosis, are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of an Ehrlichia antigen and DNA sequences encoding such polypeptides. Pharmaceutical compositions and vaccines comprising such polypeptides or DNA sequences are also provided. Diagnostic kits containingsuch polypeptides or DNA sequences and a suitable detection reagent may be used for the detection of Ehrlichia infection in patients and biological samples. Antibodies directed against such polypeptides are also provided.

    摘要翻译： 公开了用于诊断和治疗艾氏杆菌感染的特异性人粒细胞性肝炎的化合物和方法。 提供的化合物包括含有至少一种抗原部分的埃里希抗原的多肽和编码这种多肽的DNA序列。 也提供了包含这种多肽或DNA序列的药物组合物和疫苗。 含有该多肽或DNA序列的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的埃氏体感染。 还提供了针对这种多肽的抗体。

    Compounds and methods for the diagnosis and treatment of B. microti infection
    9.
    发明授权
    Compounds and methods for the diagnosis and treatment of B. microti infection 失效
    用于诊断和治疗微生物感染的化合物和方法

    公开(公告)号：US06183976B2

    公开(公告)日：2001-02-06

    申请号：US08845258

    申请日：1997-04-24

    申请人： Steven G. Reed ,  Michael J. Lodes ,  Raymond Houghton ,  Paul R. Sleath

    发明人： Steven G. Reed ,  Michael J. Lodes ,  Raymond Houghton ,  Paul R. Sleath

    IPC分类号： C07K1444

    CPC分类号： C07K14/44 ,  A61K38/00 ,  A61K39/00 ,  C07K2319/00 ,  Y02A50/401 ,  Y02A50/403 ,  Y10S530/822

    摘要： Compounds and methods for the diagnosis and treatment of B. microti infection are disclosed. The compounds provided include polypeptides that contain at least one antigenic portion of a B. microti antigen and DNA sequences encoding such polypeptides. Antigenic epitopes of such antigens are also provided, together with pharmaceutical compositions and vaccines comprising such polypeptides, DNA sequences or antigenic epitopes. Diagnostic kits containing such polypeptides, DNA sequences or antigenic epitopes and a suitable detection reagent may be used for the detection of B. microti infection in patients and biological samples. Antibodies directed against such polypeptides and antigenic epitopes are also provided.

    摘要翻译： 公开了用于诊断和治疗微生物感染的化合物和方法。 提供的化合物包括含有微生物抗原的至少一个抗原部分和编码这种多肽的DNA序列的多肽。 还提供了这样的抗原的抗原表位以及包含这种多肽，DNA序列或抗原表位的药物组合物和疫苗。 含有此类多肽，DNA序列或抗原表位的诊断试剂盒和合适的检测试剂可用于检测患者和生物样品中的微生物感染。 还提供了针对这种多肽和抗原表位的抗体。