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1.发明授权Fibronectin type III domain based scaffold compositions, methods and uses 有权纤连蛋白III型结构域的支架组合物，方法和用途公开(公告)号：US08293482B2
公开(公告)日：2012-10-23
申请号：US12704824
申请日：2010-02-12
Applicant: Steven Jacobs , Karyn O'Neil
Inventor： Steven Jacobs , Karyn O'Neil
CPC classification number: C12N15/1044 , A61K38/00 , C07K14/78 , C40B40/08 , C40B50/06
Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG based on the consensus sequence have been identified as useful for diagnostic and/or therapeutic applications.
Abstract translation: 基于来自人纤连蛋白的第十纤维连接蛋白III型（FN3）重复共有序列的蛋白质支架，包括编码蛋白质支架的分离的核酸，载体，宿主细胞及其制备和使用的方法具有诊断和/ 或治疗组合物，方法和装置。 特别地，已经鉴定了基于共有序列与IgG结合的蛋白质支架分子对于诊断和/或治疗应用是有用的。
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2.发明申请Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses 有权抗TNFα纤维结合蛋白III型结构域支架组合物，方法和用途公开(公告)号：US20100144601A1
公开(公告)日：2010-06-10
申请号：US12606396
申请日：2009-10-27
Applicant: Steven Jacobs , Karyn O'Neil
Inventor： Steven Jacobs , Karyn O'Neil
IPC: A61K38/39 , C40B40/10 , C40B30/04 , C12N15/12 , C12N15/70 , C12N15/81 , C12N15/85 , C12N5/10 , A61P17/02
CPC classification number: G01N33/54306 , A61K38/39 , C07K14/78 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463
Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Abstract translation: 基于来自人纤连蛋白（优选人腱生蛋白）的第十纤维连接蛋白III型（FN3）重复序列的蛋白质支架，其结合人TNFα，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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3.发明申请公开(公告)号：US20130096019A1
公开(公告)日：2013-04-18
申请号：US13595484
申请日：2012-08-27
Applicant: Steven Jacobs , Karyn O'Neil
Inventor： Steven Jacobs , Karyn O'Neil
IPC: C07K14/78
Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。
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公开(公告)号：US20110189790A1
公开(公告)日：2011-08-04
申请号：US12863489
申请日：2009-01-20
Applicant: Karyn O'Neil , Steven Jacobs , Shong-Juin Wu , Deldra Bethea , Ylqing Feng
Inventor： Karyn O'Neil , Steven Jacobs , Shong-Juin Wu , Deldra Bethea , Ylqing Feng
IPC: G01N30/02
CPC classification number: G01N33/6854 , B01D15/3809
Abstract: The invention provides methods for testing and ranking therapeutic antibody candidates for biophysical properties related to solubility and the susceptibility of the antibody to aggregate in aqueous solutions. The methods are useful for selecting among antibody libraries or variants for candidates which can be formulated at high concentrations.
Abstract translation: 本发明提供了用于测试和评估与溶解度相关的生物物理性质的治疗性抗体候选物和抗体在水溶液中聚集的易感性的方法。 该方法可用于在可以以高浓度配制的候选物之间选择抗体文库或变体。
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5.发明申请Anti-TNF Alpha Fibronectin Type III Domain Based Scaffold Compositions, Methods and Uses 有权抗TNFα纤维结合蛋白III型结构域支架组合物，方法和用途公开(公告)号：US20130274145A1
公开(公告)日：2013-10-17
申请号：US13845291
申请日：2013-03-18
Applicant: Steven Jacobs , Karyn O'Neil
Inventor： Steven Jacobs , Karyn O'Neil
IPC: G01N33/543
CPC classification number: G01N33/54306 , A61K38/39 , C07K14/78 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463
Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Abstract translation: 基于来自人纤连蛋白（优选人腱生蛋白）的第十纤维连接蛋白III型（FN3）重复序列的蛋白质支架，其结合人TNFα，包括分离的编码蛋白质支架的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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Patent Agency Ranking
6.发明授权Fibronectin type III domain based scaffold compositions, methods and uses 有权纤连蛋白III型结构域的支架组合物，方法和用途公开(公告)号：US08278419B2
公开(公告)日：2012-10-02
申请号：US12606382
申请日：2009-10-27
Applicant: Steven Jacobs , Karyn O'Neil
Inventor： Steven Jacobs , Karyn O'Neil
Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。
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公开(公告)号：US08722618B2
公开(公告)日：2014-05-13
申请号：US13458578
申请日：2012-04-27
Applicant: Steven Jacobs , Karyn O'Neil , Michael Baumann , Gaby Sennhauser
Inventor： Steven Jacobs , Karyn O'Neil , Michael Baumann , Gaby Sennhauser
IPC: C12N15/24 , C07K14/00 , A61P11/00 , A61P11/06 , A61P9/00 , A61P35/00 , C12P21/02 , C12N15/11 , C12N15/63 , C12N1/21 , C12N1/19 , C12N7/01 , C12N5/10 , A61K38/16 , A61P17/00
CPC classification number: C07K14/705 , A61K38/00 , C07K14/47 , C07K2319/70 , Y02A50/409 , Y02A50/423
Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.
Abstract translation: IL4 / IL13结合蛋白包含结合结构域，其抑制IL4 / IL13与IL4Ralpaha和常见的γ链复合物（1型）结合并抑制IL4与IL4Rα和IL13Ralpha1复合物（2型）的结合，IL13与IL13Rα1和/或IL13Rα2的结合 ，可用于治疗癌症，炎症和其他病理状况，如过敏或纤维化病症，特别是肺部疾病。
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公开(公告)号：US20120277143A1
公开(公告)日：2012-11-01
申请号：US13458578
申请日：2012-04-27
Applicant: Steven Jacobs , Karyn O'Neil , Michael Baumann , Gaby Sennhauser
Inventor： Steven Jacobs , Karyn O'Neil , Michael Baumann , Gaby Sennhauser
IPC: C07K14/00 , A61P11/00 , A61P11/06 , A61P9/00 , A61P35/00 , C12P21/02 , C12N15/11 , C12N15/63 , C12N1/21 , C12N1/19 , C12N7/01 , C12N5/10 , A61K38/16 , A61P17/00
CPC classification number: C07K14/705 , A61K38/00 , C07K14/47 , C07K2319/70 , Y02A50/409 , Y02A50/423
Abstract: IL4/IL13-binding proteins comprise binding domains, which inhibit IL4/IL13 binding to IL4Ralpaha and common gamma chain complexes (Type 1) and inhibit IL4 binding to IL4Ralpha and IL13Ralpha1 complexes (Type 2), and IL13 binding to IL13Ralpha1 and/or IL13Ralpha2, are useful in the treatment of cancer, inflammatory, and other pathological conditions, such as allergic or fibrotic conditions, especially pulmonary conditions.
Abstract translation: IL4 / IL13结合蛋白包含结合结构域，其抑制IL4 / IL13与IL4Ralpaha和常见的γ链复合物（1型）结合并抑制IL4与IL4Rα和IL13Ralpha1复合物（2型）的结合，IL13与IL13Rα1和/或IL13Rα2的结合 ，可用于治疗癌症，炎症和其他病理状况，如过敏或纤维化病症，特别是肺部疾病。
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9.发明申请公开(公告)号：US20100216708A1
公开(公告)日：2010-08-26
申请号：US12606382
申请日：2009-10-27
Applicant: Steven Jacobs , Karyn O'Neil
Inventor： Steven Jacobs , Karyn O'Neil
IPC: A61K38/16 , C07K14/00 , C40B50/00 , C40B40/10 , C07H21/04 , C12N15/63 , C12N1/21 , C12N1/19 , C12N5/10
Abstract: A protein scaffold based on a consensus sequence of fibronectin type III (FN3) proteins, such as the tenth FN3 repeat from human fibronectin (human Tenascin), including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices. In particular, protein scaffold molecules binding to IgG have been identified as useful for diagnostic and/or therapeutic applications.
Abstract translation: 基于纤连蛋白III（FN3）蛋白的共有序列的蛋白质支架，例如来自人纤连蛋白（人腱生蛋白）的第十FN3重复序列，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。 特别地，已经鉴定了结合IgG的蛋白质支架分子可用于诊断和/或治疗应用。
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10.发明授权Anti-TNF alpha fibronectin type III domain based scaffold compositions, methods and uses 有权抗TNFα纤连蛋白III型结构域的支架组合物，方法和用途公开(公告)号：US08415291B2
公开(公告)日：2013-04-09
申请号：US12606396
申请日：2009-10-27
Applicant: Steven Jacobs , Karyn O'Neil
Inventor： Steven Jacobs , Karyn O'Neil
CPC classification number: G01N33/54306 , A61K38/39 , C07K14/78 , Y02A50/385 , Y02A50/401 , Y02A50/409 , Y02A50/411 , Y02A50/463
Abstract: A protein scaffold based on a consensus sequence of the tenth fibronectin type III (FN3) repeat from human fibronectin, preferably human Tenascin, that binds to human TNFα including isolated nucleic acids that encode a protein scaffold, vectors, host cells, and methods of making and using thereof have applications in diagnostic and/or therapeutic compositions, methods and devices.
Abstract translation: 基于来自人纤连蛋白（优选人腱生蛋白）的第十纤维连接蛋白III型（FN3）重复序列的蛋白质支架，其结合人TNFα，包括编码蛋白质支架的分离的核酸，载体，宿主细胞和制备方法 并且其使用在诊断和/或治疗组合物，方法和装置中具有应用。
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