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公开(公告)号:US07741327B2
公开(公告)日:2010-06-22
申请号:US12400065
申请日:2009-03-09
申请人: Steven Joseph Berthel , John A Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人: Steven Joseph Berthel , John A Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号: A61K31/497 , A61K31/4439 , A61K31/433 , A61K31/428 , A61K31/426 , A61K31/423 , A61K31/421 , A61K31/4155 , C07D403/12 , C07D401/12 , C07D285/08 , C07D277/82 , C07D277/38 , C07D263/54 , C07D263/48 , C07D231/56 , C07D231/38
CPC分类号: C07D403/12 , C07D401/12 , C07D405/14 , C07D413/14 , C07D417/12
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US20090264445A1
公开(公告)日:2009-10-22
申请号:US12400065
申请日:2009-03-09
申请人: Steven Joseph Berthel , John A. Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人: Steven Joseph Berthel , John A. Brinkman , Stuart Hayden , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号: A61K31/497 , C07D403/12 , A61K31/4155
CPC分类号: C07D403/12 , C07D401/12 , C07D405/14 , C07D413/14 , C07D417/12
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US20090264434A1
公开(公告)日:2009-10-22
申请号:US12400319
申请日:2009-03-09
申请人: Steven Joseph Berthel , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人: Steven Joseph Berthel , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号: A61K31/502 , C07D237/02 , A61K31/50 , C07D237/30 , A61P3/10
CPC分类号: C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/14
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US08258134B2
公开(公告)日:2012-09-04
申请号:US12400319
申请日:2009-03-09
申请人: Steven Joseph Berthel , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
发明人: Steven Joseph Berthel , Nancy-Ellen Haynes , Robert Francis Kester , Lee Apostle McDermott , Yimin Qian , Ramakanth Sarabu , Nathan Robert Scott , Jefferson Wright Tilley
IPC分类号: C07D401/06 , C07D401/14 , C07D237/32 , C07D237/10 , A61K31/501 , A61K31/502 , A61P5/50
CPC分类号: C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D407/14
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US20110144105A1
公开(公告)日:2011-06-16
申请号:US12943539
申请日:2010-11-10
申请人: Steven Joseph Berthel , Li Chen , Wendy Lea Corbett , LiChun Feng , Nancy-Ellen Haynes , Robert Francis Kester , Sung-Sau So , Jefferson Wright Tilley
发明人: Steven Joseph Berthel , Li Chen , Wendy Lea Corbett , LiChun Feng , Nancy-Ellen Haynes , Robert Francis Kester , Sung-Sau So , Jefferson Wright Tilley
IPC分类号: A61K31/437 , A61K31/5377 , C07D471/04 , A61P3/10 , A61P3/00
CPC分类号: C07D471/04 , C07C2601/04 , C07C2601/06 , C07D401/06 , C07D403/10 , C07D405/06
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US08222416B2
公开(公告)日:2012-07-17
申请号:US12943539
申请日:2010-11-10
申请人: Steven Joseph Berthel , Li Chen , Wendy Lea Corbett , Lichun Feng , Nancy-Ellen Haynes , Robert Francis Kester , Sung-Sau So , Jefferson Wright Tilley
发明人: Steven Joseph Berthel , Li Chen , Wendy Lea Corbett , Lichun Feng , Nancy-Ellen Haynes , Robert Francis Kester , Sung-Sau So , Jefferson Wright Tilley
IPC分类号: C07D471/02 , A61K31/545
CPC分类号: C07D471/04 , C07C2601/04 , C07C2601/06 , C07D401/06 , C07D403/10 , C07D405/06
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of metabolic diseases and disorders such as, for example, type II diabetes mellitus.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗代谢疾病和病症,例如II型糖尿病。
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公开(公告)号:US07803816B2
公开(公告)日:2010-09-28
申请号:US11526523
申请日:2006-09-25
申请人: Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
发明人: Steven Joseph Berthel , Shawn David Erickson , Nader Fotouhi , Robert Francis Kester , Kyungjin Kim , Steven Gregory Mischke , Yimin Qian , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Hong Wang
IPC分类号: A61K31/454 , C07D403/02
CPC分类号: C07D401/04 , C07D401/14 , C07D471/04
摘要: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of obesity, hyperphagia, anxiety, depression and related disorders and diseases.
摘要翻译: 本文提供式(I)的化合物及其药学上可接受的盐,其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗肥胖,食欲过盛,焦虑,抑郁和相关疾病和疾病。
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公开(公告)号:US07935699B2
公开(公告)日:2011-05-03
申请号:US11879935
申请日:2007-07-19
申请人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Ramakanth Sarabu , Chinh Viet Tran , Dionisios Vourloumis
发明人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Ramakanth Sarabu , Chinh Viet Tran , Dionisios Vourloumis
IPC分类号: A61K31/5377 , A61K31/415 , A61P3/00 , C07D231/00
CPC分类号: C07D231/40 , C07D405/12 , C07D413/06
摘要: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
摘要翻译: 本文公开了可用于治疗代谢性疾病和病症(优选糖尿病)的式(I)的吡唑葡糖激酶活化剂。
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公开(公告)号:US20080021032A1
公开(公告)日:2008-01-24
申请号:US11879935
申请日:2007-07-19
申请人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Ramakanth Sarabu , Chinh Viet Tran , Dionisios Vourloumis
发明人: Steven Joseph Berthel , Robert Francis Kester , Douglas Eric Murphy , Thomas Jay Prins , Frank Ruebsam , Ramakanth Sarabu , Chinh Viet Tran , Dionisios Vourloumis
IPC分类号: A61K31/5377 , A61K31/415 , A61P3/00 , A61P3/10
CPC分类号: C07D231/40 , C07D405/12 , C07D413/06
摘要: Disclosed herein are pyrazole glucokinase activators of the formula (I) useful for the treatment of metabolic diseases and disorders, preferably diabetes mellitus.
摘要翻译: 本文公开了可用于治疗代谢性疾病和病症(优选糖尿病)的式(I)的吡唑葡糖激酶活化剂。
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公开(公告)号:US20120230951A1
公开(公告)日:2012-09-13
申请号:US13414854
申请日:2012-03-08
申请人: Muzaffar Alam , Steven Joseph Berthel , John A. Brinkman , Ronald Charles Hawley , Hongju Li , Wylie Solang Palmer , Sherrie Pietranico-Cole , Ramakanth Sarabu , Mark Smith , Sung-Sau So , Lin Yi , Yansheng Zhai , Qiang Zhang , Shu-Hai Zhao
发明人: Muzaffar Alam , Steven Joseph Berthel , John A. Brinkman , Ronald Charles Hawley , Hongju Li , Wylie Solang Palmer , Sherrie Pietranico-Cole , Ramakanth Sarabu , Mark Smith , Sung-Sau So , Lin Yi , Yansheng Zhai , Qiang Zhang , Shu-Hai Zhao
IPC分类号: A61K31/55 , A61P37/02 , A61P31/14 , A61K38/21 , C07D487/06 , A61K31/551
CPC分类号: C07D487/06 , A61K31/55 , A61K31/551 , A61K45/06 , C07D519/00 , A61K2300/00
摘要: The present invention provides compounds, compositions and methods for the treatment of hepatitis C virus (HCV) infection. Also disclosed are pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment of HCV infection.
摘要翻译: 本发明提供用于治疗丙型肝炎病毒(HCV)感染的化合物,组合物和方法。 还公开了含有这些化合物的药物组合物和使用这些化合物治疗HCV感染的方法。
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