公开(公告)号：US06538739B1

公开(公告)日：2003-03-25

申请号：US08941015

申请日：1997-09-30

申请人： Steven R. Visuri ,  Beth M. Mammini ,  Luiz B. Da Silva ,  Peter M. Celliers

发明人： Steven R. Visuri ,  Beth M. Mammini ,  Luiz B. Da Silva ,  Peter M. Celliers

IPC分类号： G01B1100

CPC分类号： G01N21/431 ,  A61B18/20 ,  A61B18/26 ,  A61B2017/00057 ,  A61B2017/22008 ,  A61B2018/00636

摘要： The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.

摘要翻译： 本发明旨在作为诊断气泡的存在并将该信息并入用于光声溶解的反馈系统中的手段。 在光声波溶解中，超声频率下的脉冲激光辐射在光纤内向内递送并引向血栓或其它闭塞血管。 因此，阻塞的溶解通过传播压力或冲击波的超声波作用来介导。 作为激光照射的结果，可以形成围绕闭塞的流体中的蒸气泡。 该气泡可用于直接破坏闭塞或产生压力波的手段。 需要检测形成并遵循蒸气泡的寿命。 关于气泡形成和寿命的知识产生关于气泡的最大尺寸，吸收辐射的密度和吸收材料的性质的关键信息。 然后可以在反馈系统中使用该信息来改变照射条件。