公开(公告)号：US06538739B1

公开(公告)日：2003-03-25

申请号：US08941015

申请日：1997-09-30

申请人： Steven R. Visuri ,  Beth M. Mammini ,  Luiz B. Da Silva ,  Peter M. Celliers

发明人： Steven R. Visuri ,  Beth M. Mammini ,  Luiz B. Da Silva ,  Peter M. Celliers

IPC分类号： G01B1100

CPC分类号： G01N21/431 ,  A61B18/20 ,  A61B18/26 ,  A61B2017/00057 ,  A61B2017/22008 ,  A61B2018/00636

摘要： The present invention is intended as a means of diagnosing the presence of a gas bubble and incorporating the information into a feedback system for opto-acoustic thrombolysis. In opto-acoustic thrombolysis, pulsed laser radiation at ultrasonic frequencies is delivered intraluminally down an optical fiber and directed toward a thrombus or otherwise occluded vessel. Dissolution of the occlusion is therefore mediated through ultrasonic action of propagating pressure or shock waves. A vapor bubble in the fluid surrounding the occlusion may form as a result of laser irradiation. This vapor bubble may be used to directly disrupt the occlusion or as a means of producing a pressure wave. It is desirable to detect the formation and follow the lifetime of the vapor bubble. Knowledge of the bubble formation and lifetime yields critical information as to the maximum size of the bubble, density of the absorbed radiation, and properties of the absorbing material. This information can then be used in a feedback system to alter the irradiation conditions.

摘要翻译： 本发明旨在作为诊断气泡的存在并将该信息并入用于光声溶解的反馈系统中的手段。 在光声波溶解中，超声频率下的脉冲激光辐射在光纤内向内递送并引向血栓或其它闭塞血管。 因此，阻塞的溶解通过传播压力或冲击波的超声波作用来介导。 作为激光照射的结果，可以形成围绕闭塞的流体中的蒸气泡。 该气泡可用于直接破坏闭塞或产生压力波的手段。 需要检测形成并遵循蒸气泡的寿命。 关于气泡形成和寿命的知识产生关于气泡的最大尺寸，吸收辐射的密度和吸收材料的性质的关键信息。 然后可以在反馈系统中使用该信息来改变照射条件。

公开(公告)号：US06368318B1

公开(公告)日：2002-04-09

申请号：US09012379

申请日：1998-01-23

申请人： Steven R. Visuri ,  Luiz B. Da Silva ,  Peter M. Celliers ,  Richard A. London ,  William Benett ,  Kathryn Broughton ,  Victor Esch

发明人： Steven R. Visuri ,  Luiz B. Da Silva ,  Peter M. Celliers ,  Richard A. London ,  William Benett ,  Kathryn Broughton ,  Victor Esch

IPC分类号： A61B1818

CPC分类号： A61B18/26 ,  A61B18/245 ,  A61B2017/22061 ,  A61B2018/00029 ,  A61B2018/2211

摘要： Fiber delivered laser pulses emulsify thrombus by mechanical stresses that include a combination of pressure, tension and shear stress. Laser radiation is delivered to the locality of a thrombus and the radiation is absorbed by blood, blood dot, or other present materials. The combination of a leading pressure wave and subsequent vapor bubble cause efficient, emulsification of thrombus. Operating the laser in a low average power mode alleviates potential thermal complications. The laser is operated in a high repetition rate mode to take advantage of ultrasound frequency effects of thrombus dissolution as well as to decrease the total procedure time. Specific parameter ranges for operation are described. The device includes optical fibers surrounding a lumen intended for flow of a cooling agent. The fibers may be arranged concentrically around the lumen to deliver radiation and heat over as large an area as possible. An alternative design approach incorporates the optical fibers into the wall of the guiding catheter and utilizes the catheter lumen as the cooling channel. An eccentric tip enables rotation of the device to address all parts of the vasculature. The eccentricity can be provided via a variety of means: spring dip, balloon, protrusion, etc.

摘要翻译： 纤维传递的激光脉冲通过机械应力乳化血栓，包括压力，张力和剪切应力的组合。 激光辐射被输送到血栓的位置，并且辐射被血液，血液点或其他现有材料吸收。 导致压力波和随后的蒸汽气泡的组合导致血栓的有效的乳化。 以较低的平均功率模式操作激光可以减轻潜在的并发症。 激光以高重复率模式运行，以利用血栓溶解的超声频率效应以及减少总的手术时间。 描述操作的具体参数范围。 该装置包括围绕用于冷却剂流动的内腔的光纤。 纤维可以围绕内腔同心地布置，以在尽可能大的面积上传送辐射和热量。 另一种设计方法将光纤结合到引导导管的壁中并利用导管内腔作为冷却通道。 偏心的尖端能够使装置旋转以解决脉管系统的所有部分。 偏心度可以通过各种方式提供：弹簧浸渍，气球，突起等

公开(公告)号：US5722989A

公开(公告)日：1998-03-03

申请号：US812142

申请日：1997-03-06

申请人： Joseph P. Fitch ,  Karla Hagans ,  Robert Clough ,  Dennis L. Matthews ,  Abraham P. Lee ,  Peter A. Krulevitch ,  William J. Benett ,  Luiz Da Silva ,  Peter M. Celliers

发明人： Joseph P. Fitch ,  Karla Hagans ,  Robert Clough ,  Dennis L. Matthews ,  Abraham P. Lee ,  Peter A. Krulevitch ,  William J. Benett ,  Luiz Da Silva ,  Peter M. Celliers

IPC分类号： B25J15/08 ,  A61B17/00 ,  A61B17/12 ,  A61B17/28 ,  A61B19/00 ,  B81B3/00

CPC分类号： A61B17/1214 ,  A61B17/12022 ,  A61B17/29 ,  A61B2017/00292 ,  A61B2017/00345 ,  A61B2017/00398 ,  A61B2017/1205 ,  A61B2017/12068 ,  A61B2017/12077 ,  A61B2017/12081 ,  A61B2017/2926

摘要： A micro-mechanical system for medical procedures is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a near end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a near end for external coupling of laser light energy. A microgripper is attached to the distal end of the catheter and providing for the gripping or releasing of an object within the body. A laser-light-to-mechanical-power converter is connected to receive laser light from the distal end of the fiberoptic cable and connected to mechanically actuate the microgripper.

摘要翻译： 用于医疗程序的微机械系统以导管的基本形式构造，其具有用于插入身体内部和在身体内操作的远端，并且近端提供用户以控制身体内的远端的操纵。 光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。 微型抓爪附接到导管的远端，并提供用于在体内夹持或释放物体。 连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的激光并连接到机械致动微型抓爪。

公开(公告)号：US5986234A

公开(公告)日：1999-11-16

申请号：US829519

申请日：1997-03-28

申请人： Dennis L. Matthews ,  Peter M. Celliers ,  Lloyd Hackel ,  Luiz B. Da Silva ,  C. Brent Dane ,  Stanley Mrowka

发明人： Dennis L. Matthews ,  Peter M. Celliers ,  Lloyd Hackel ,  Luiz B. Da Silva ,  C. Brent Dane ,  Stanley Mrowka

IPC分类号： B08B7/00 ,  B23K26/14 ,  B23K26/00

CPC分类号： B23K26/032 ,  B08B7/0042 ,  B23K26/066 ,  B23K26/0884 ,  B23K26/142 ,  B23K26/1476

摘要： A compact laser system that removes surface coatings (such as paint, dirt, etc.) at a removal rate as high as 1000 ft.sup.2 /hr or more without damaging the surface. A high repetition rate laser with multiple amplification passes propagating through at least one optical amplifier is used, along with a delivery system consisting of a telescoping and articulating tube which also contains an evacuation system for simultaneously sweeping up the debris produced in the process. The amplified beam can be converted to an output beam by passively switching the polarization of at least one amplified beam. The system also has a personal safety system which protects against accidental exposures.

摘要翻译： 一种紧凑的激光系统，可以以高达1000 ft2 / hr或更高的去除率去除表面涂层（如油漆，污垢等），而不会损坏表面。 使用通过至少一个光学放大器传播的具有多次放大的高重复率激光，以及包括伸缩和铰接管的输送系统，该输送系统还包含用于同时扫掠在该过程中产生的碎片的抽空系统。 放大的光束可以通过被动地切换至少一个放大的光束的偏振而被转换成输出光束。 该系统还具有防止意外暴露的个人安全系统。

公开(公告)号：US06876723B1

公开(公告)日：2005-04-05

申请号：US10613223

申请日：2003-07-01

申请人： Peter M. Celliers ,  Franz A. Weber ,  Stephen J. Moon

发明人： Peter M. Celliers ,  Franz A. Weber ,  Stephen J. Moon

IPC分类号： G01N23/20 ,  G01N23/00 ,  H05G1/64

CPC分类号： G01N23/20

摘要： A pump-probe scheme measures the rise time of ultrafast x-ray pulses. Conventional high speed x-ray diagnostics (x-ray streak cameras, PIN diodes, diamond PCD devices) do not provide sufficient time resolution to resolve rise times of x-ray pulses on the order of 50 fs or less as they are being produced by modern fast x-ray sources. Here, we are describing a pump-probe technique that can be employed to measure events where detector resolution is insufficient to resolve the event. The scheme utilizes a diamond plate as an x-ray transducer and a p-polarized probe beam.

摘要翻译： 泵浦探针方案测量超快x射线脉冲的上升时间。 传统的高速x射线诊断（x射线条纹相机，PIN二极管，金刚石PCD器件）不能提供足够的时间分辨率来解决大约50fs或更小的x射线脉冲的上升时间，因为它们由 现代快速X射线源。 在这里，我们将描述一种泵探针技术，可用于测量检测器分辨率不足以解决事件的事件。 该方案利用金刚石板作为X射线传感器和p偏振探测光束。

公开(公告)号：US06575965B1

公开(公告)日：2003-06-10

申请号：US09713988

申请日：2000-11-16

申请人： Joseph P. Fitch ,  Dennis L. Matthews ,  Karla G. Hagans ,  Abraham P. Lee ,  Peter Krulevitch ,  William J. Benett ,  Robert E. Clough ,  Luiz B. DaSilva ,  Peter M. Celliers

发明人： Joseph P. Fitch ,  Dennis L. Matthews ,  Karla G. Hagans ,  Abraham P. Lee ,  Peter Krulevitch ,  William J. Benett ,  Robert E. Clough ,  Luiz B. DaSilva ,  Peter M. Celliers

IPC分类号： A61B1822

CPC分类号： A61B17/12022 ,  A61B5/0084 ,  A61B17/1214 ,  A61B17/29 ,  A61B2017/00292 ,  A61B2017/00345 ,  A61B2017/12072 ,  A61B2017/12077 ,  A61B2017/2926

摘要： A medical device is constructed in the basic form of a catheter having a distal end for insertion into and manipulation within a body and a proximal end providing for a user to control the manipulation of the distal end within the body. A fiberoptic cable is disposed within the catheter and having a distal end proximate to the distal end of the catheter and a proximal end for external coupling of laser light energy. A laser-light-to-mechanical-power converter is connected to receive light from the distal end of the fiber optic cable and may include a photo-voltaic cell and an electromechanical motor or a heat-sensitive photo-thermal material. An electronic sensor is connected to receive electrical power from said distal end of the fiberoptic cable and is connected to provide signal information about a particular physical environment and communicated externally through the fiberoptic cable to the proximal end thereof. A mechanical sensor is attached to the distal end of the fiberoptic cable and connected to provide light signal information about a particular physical environment and communicated externally through the fiberoptic cable.

摘要翻译： 医疗装置构造成具有导管的基本形式，其具有用于插入体内和在体内操作的远端，并且近端为使用者提供控制体内远端的操作。 光纤电缆设置在导管内并且具有靠近导管远端的远端和用于激光光能的外部耦合的近端。 连接激光 - 光机械功率转换器以接收来自光纤电缆的远端的光，并且可以包括光电池和机电马达或热敏光热材料。 电子传感器被连接以从光纤电缆的所述远端接收电力，并且被连接以提供关于特定物理环境的信号信息，并且通过光纤电缆向外传播到其近端。 机械传感器连接到光纤电缆的远端并被连接以提供关于特定物理环境的光信号信息，并通过光纤电缆在外部通信。

公开(公告)号：US06428531B1

公开(公告)日：2002-08-06

申请号：US09604454

申请日：2000-06-27

申请人： Steven R. Visuri ,  Luiz B. Da Silva ,  Peter M. Celliers ,  Richard A. London ,  Duncan J. Maitland, IV ,  Victor C. Esch

发明人： Steven R. Visuri ,  Luiz B. Da Silva ,  Peter M. Celliers ,  Richard A. London ,  Duncan J. Maitland, IV ,  Victor C. Esch

IPC分类号： A61B1818

CPC分类号： A61B18/245 ,  A61B2018/20359 ,  A61B2018/2211

摘要： Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.

摘要翻译： 通过将光纤阵列定位在通道中并沿着纤维一次一个地引导处理辐射脉冲来去除人体内的流体通道的部分或全部闭塞，以产生冲击波和流体动力学流动，其冲击和乳化 闭塞。 优选的应用是从小脑血管去除血块（凝血酶和栓塞）以逆转缺血性卒中的作用。 选择操作参数和技术以最小化在此光声处理期间发生的脆弱的脑血管壁的加热量。 一种这样的技术是当期望发生流体动力学流动产生蒸汽气泡的存在时的光学监测，并且停止沿着不产生这种气泡的光纤传播的发热脉冲。