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    FOCUSED INTRALUMINAL LITHECTOMY CATHETER DEVICE AND METHODS
    1.
    发明申请
    FOCUSED INTRALUMINAL LITHECTOMY CATHETER DEVICE AND METHODS 审中-公开

    公开(公告)号：US20190150961A1

    公开(公告)日：2019-05-23

    申请号：US16188771

    申请日：2018-11-13

    申请人： Sonic Vascular, LLC

    发明人： Michael J. Tozzi

    IPC分类号： A61B17/22

    CPC分类号： A61B17/22022 ,  A61B17/2251 ,  A61B2017/00411 ,  A61B2017/22008 ,  A61B2017/22024 ,  A61B2017/22025 ,  A61B2017/22062 ,  A61B2017/22074

    摘要： A system, device and method for removing occlusive material from a bodily lumen comprising a catheter with a distally mounted and fluid-fillable litho-cushion in operative connection with at least one forward-focusing reflector. The catheter comprises a lumen with an electrode pair housing disposed in watertight engagement with the lumen at or near the distal end of the lumen, the electrode pair housing comprising at least one electrode pair. The at least one electrode pair is in wired communication with a pulse generator, wherein the electrode pair is configured to generate an electrical arc between the electrodes of the electrode pair with subsequent generation of a shock wave. The shock wave is directed distally out of the catheter lumen and focused forward and distally away from the catheter lumen by the at least one reflector toward the targeted occlusive material.

    Spherical ultrasonic HIFU transducer with modular cavitation sense element
    4.
    发明授权
    Spherical ultrasonic HIFU transducer with modular cavitation sense element 有权
    具有模块化空穴感应元件的球形超声波HIFU换能器

    公开(公告)号：US09555268B2

    公开(公告)日：2017-01-31

    申请号：US14113670

    申请日：2012-05-08

    申请人： Dennis Dean Clark

    发明人： Dennis Dean Clark

    IPC分类号： A61B8/00 ,  A61N7/02 ,  A61B17/00 ,  A61B17/22 ,  A61N7/00

    CPC分类号： A61N7/02 ,  A61B2017/00106 ,  A61B2017/22008 ,  A61N2007/0065

    摘要： An ultrasonic HIFU transducer (120) has a threaded opening into which a modular cavitation sensor (90) is removably located. The modular cavitation sensor includes a modular housing (92) containing a piezoelectric transducer for sensing acoustic signals indicative of cavitation. The modular cavitation sensor has electrodes (96,98) which engage spring contacts (112,114) in the threaded opening when the modular housing is screwed into the threaded opening. A damaged sensor can be unscrewed and replaced simply without connectors or soldering.

    摘要翻译： 超声波HIFU换能器（120）具有螺纹开口，模块化空化传感器（90）可移除地位于该开口中。 模块化空化传感器包括模块化壳体（92），其包含用于感测指示空化的声信号的压电换能器。 模块化空化传感器具有电极（96,98），当模块化壳体拧入螺纹开口时，电极（96,98）接合螺纹孔中的弹簧触头（112,114）。 损坏的传感器可以拧开，而不需要连接器或焊接即可更换。

    Devices and methods for selectively lysing cells
    8.
    发明授权
    Devices and methods for selectively lysing cells 有权
    用于选择性裂解细胞的装置和方法

    公开(公告)号：US09248317B2

    公开(公告)日：2016-02-02

    申请号：US11771932

    申请日：2007-06-29

    申请人： Adnan I. Merchant ,  Mark E. Deem

    发明人： Adnan I. Merchant ,  Mark E. Deem

    IPC分类号： A61N7/00 ,  A61B17/225 ,  A61B17/00 ,  A61B17/22 ,  A61N1/32

    CPC分类号： A61N7/00 ,  A61B2017/00747 ,  A61B2017/22008 ,  A61N1/327 ,  A61N2007/0008 ,  A61N2007/0039

    摘要： A device for generating microbubbles in a gas and liquid mixture and injection device, the device comprising: a housing defining a mixing chamber; means for mixing solution contained in the mixing chamber to generate microbubbles in the solution; a needle array removably attached to the housing and in fluid connection with the mixing chamber, the needle array including at least one needle; and a machine readable identifier on the needle array.

    摘要翻译： 一种用于在气体和液体混合物和注射装置中产生微泡的装置，所述装置包括：限定混合室的壳体; 用于混合包含在混合室中的溶液以在溶液中产生微泡的装置; 针阵列，其可移除地附接到所述壳体并与所述混合室流体连接，所述针阵列包括至少一个针; 和针阵列上的机器可读标识符。

    FREQUENCY COMPOUNDING ULTRASOUND PULSES FOR IMAGING AND THERAPY
    9.
    发明申请
    FREQUENCY COMPOUNDING ULTRASOUND PULSES FOR IMAGING AND THERAPY 审中-公开
    用于成像和治疗的频率复合超声波脉冲

    公开(公告)号：US20150258352A1

    公开(公告)日：2015-09-17

    申请号：US14656633

    申请日：2015-03-12

    申请人： Kuang-Wei LIN ,  Charles A. CAIN

    发明人： Kuang-Wei LIN ,  Charles A. CAIN

    IPC分类号： A61N7/00 ,  A61B17/22

    CPC分类号： A61B17/22004 ,  A61B2017/22008 ,  A61N7/02 ,  A61N7/022 ,  A61N2007/0039 ,  A61N2007/0052 ,  A61N2007/0073 ,  A61N2007/0078

    摘要： Methods and devices for producing cavitation in tissue are provided. In one embodiment, a low-frequency ultrasound pulse is transmitted into tissue, a high-frequency ultrasound pulse is transmitted into tissue, and a composite waveform is formed in the tissue that has a peak negative pressure value that exceeds an intrinsic threshold for cavitation in the tissue. In some embodiments, the peak negative pressures of the individual ultrasound pulses do not exceed the intrinsic threshold for cavitation. In another embodiment, a plurality of ultrasound pulses at various resonant frequencies are transmitted into tissue, and the time delays between these transmissions are adjusted to allow the ultrasound pulses to align temporally and form a monopolar pulse having a compound peak negative pressure that exceeds an intrinsic threshold for cavitation in the tissue. Systems for performing Histotripsy therapy are also discussed.

    摘要翻译： 提供了用于在组织中产生空化的方法和装置。 在一个实施例中，将低频超声脉冲传输到组织中，将高频超声脉冲传输到组织中，并且在组织中形成复合波形，该组合具有超过空化的固有阈值的峰值负压值 组织。 在一些实施例中，各个超声脉冲的峰值负压不超过空化的固有阈值。 在另一个实施例中，将多个谐振频率的多个超声脉冲传输到组织中，并且调整这些传输之间的时间延迟以允许超声波脉冲在时间上对准并形成具有超过内在的复合峰值负压的单极脉冲 组织中空化的阈值。 还讨论了用于进行组织切除术治疗的系统。