Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same
    2.
    发明授权
    Compositions for treatment of hemorrhaging with activated factor VIIa in combination with fibrinogen and methods of using same 失效
    用于治疗活化因子VIIa与纤维蛋白原组合出血的组合物及其使用方法

    公开(公告)号:US06825323B2

    公开(公告)日:2004-11-30

    申请号:US09756907

    申请日:2001-01-10

    申请人: John R. Hess

    发明人: John R. Hess

    IPC分类号: A61K3836

    CPC分类号: A61K38/36

    摘要: The combination of recombinant factor VIIa and fibrinogen is effective in treatment for bleeding where direct pressure, tourniquets, indirect pressure, surgical ligation, bandaging, and transfusion of blood or plasma products are typically used. The combination of factor VIIa and fibrinogen is administered intravenously, either sequentially or simultaneously. The compositions may be safely circulated in the blood vessels to sites of injury. This is effective for single or multiple external or internal wounds.

    摘要翻译: 重组因子VIIa和纤维蛋白原的组合在通常使用直接压力,止血带,间接压力,手术结扎,绷带和输血血液或血浆产品的出血治疗中是有效的。 因子VIIa和纤维蛋白原的组合依次或同时静脉内施用。 组合物可以在血管中安全地循环到损伤部位。 这对于单个或多个外部或内部伤口是有效的。

    Compositions and methods for the storage of red blood cells
    4.
    发明授权
    Compositions and methods for the storage of red blood cells 有权
    用于储存红细胞的组合物和方法

    公开(公告)号:US09314014B2

    公开(公告)日:2016-04-19

    申请号:US11060026

    申请日:2005-02-17

    IPC分类号: A01N1/02 C12N5/078

    摘要: The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one non-metabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions.

    摘要翻译: 本发明提供用于储存红细胞的水性组合物,其基本上由以下组成:腺嘌呤; 葡萄糖; 至少一种不可代谢的膜保护剂糖; 和一个特别定义的pH缓冲系统。 还提供了用于保存红细胞的改进方法和用于增加存活力,膜保留性和可恢复性的方法,同时抑制利用新组合物的储存的红细胞的凋亡,溶血和再灌注后清除。

    Prolonged storage of red blood cells
    5.
    发明授权
    Prolonged storage of red blood cells 有权
    长时间储存​​红细胞

    公开(公告)号:US06447987B1

    公开(公告)日:2002-09-10

    申请号:US09664635

    申请日:2000-09-19

    IPC分类号: A01N102

    CPC分类号: A01N1/0226 A01N1/02

    摘要: Novel additive solutions useful for the storage of human red blood cells (RBCs) under refrigerated conditions are disclosed. Also disclosed is a method of using the additive solutions in an appropriate volume to preserve RBCs at about 1 to 6° C. for up to at least about 11 weeks or more. Additive solutions and processes in accordance with the present invention allow the viable storage of human RBCs for an extended period of time in a solution which is directly infusible in humans.

    摘要翻译: 公开了用于在冷藏条件下储存人红细胞(RBC)的新型添加剂溶液。 还公开了一种使用适当体积的添加剂溶液以在约1至6℃下保存高达至少约11周或更长时间的RBC的方法。 根据本发明的添加剂溶液和方法允许人类RBC在可直接不溶于人的溶液中长时间存活。

    Compositions substantially free of sodium chloride and methods for the storage of red blood cells
    6.
    发明授权
    Compositions substantially free of sodium chloride and methods for the storage of red blood cells 有权
    基本上不含氯化钠的组合物和储存红细胞的方法

    公开(公告)号:US08709707B2

    公开(公告)日:2014-04-29

    申请号:US13608682

    申请日:2012-09-10

    IPC分类号: A01N1/02

    摘要: The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one nonmetabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions.

    摘要翻译: 本发明提供用于储存红细胞的水性组合物,其基本上由以下组成:腺嘌呤; 葡萄糖; 至少一种不可代谢的膜保护剂糖; 和一个特别定义的pH缓冲系统。 还提供了用于保存红细胞的改进方法和用于增加存活力,膜保留性和可恢复性的方法,同时抑制利用新组合物的储存的红细胞的凋亡,溶血和再灌注后清除。

    COMPOSITIONS AND METHODS FOR THE STORAGE OF RED BLOOD CELLS
    7.
    发明申请
    COMPOSITIONS AND METHODS FOR THE STORAGE OF RED BLOOD CELLS 审中-公开
    用于储存红血细胞的组合物和方法

    公开(公告)号:US20120129148A1

    公开(公告)日:2012-05-24

    申请号:US13354601

    申请日:2012-01-20

    IPC分类号: A01N1/02

    摘要: The present invention provides an aqueous composition for storage of red blood cells consisting essentially of: adenine; dextrose; at least one nonmetabolizable membrane-protectant sugar; and a specifically defined pH buffering system. Also provided are improved methods for preserving red blood cells and methods for increasing the viability, membrane retention, and recoverability while suppressing apoptosis, hemolysis, and post-reinfusion clearance of stored red blood cells which utilize the novel compositions.

    摘要翻译: 本发明提供用于储存红细胞的水性组合物,其基本上由以下组成:腺嘌呤; 葡萄糖; 至少一种不可代谢的膜保护剂糖; 和一个特别定义的pH缓冲系统。 还提供了用于保存红细胞的改进方法和用于增加存活力,膜保留性和可恢复性的方法,同时抑制利用新组合物的储存的红细胞的凋亡,溶血和再灌注后清除。

    Measuring spatial variability in soil characteristics
    8.
    发明授权
    Measuring spatial variability in soil characteristics 失效
    测量土壤特性的空间变异性

    公开(公告)号:US06497153B1

    公开(公告)日:2002-12-24

    申请号:US09677183

    申请日:2000-09-28

    IPC分类号: G01B500

    摘要: The present invention provides systems and methods for measuring a load force associated with pulling a farm implement through soil that is used to generate a spatially variable map that represents the spatial variability of the physical characteristics of the soil. An instrumented hitch pin configured to measure a load force is provided that measures the load force generated by a farm implement when the farm implement is connected with a tractor and pulled through or across soil. Each time a load force is measured, a global positioning system identifies the location of the measurement. This data is stored and analyzed to generate a spatially variable map of the soil. This map is representative of the physical characteristics of the soil, which are inferred from the magnitude of the load force.

    摘要翻译: 本发明提供了用于测量与通过土壤拉动农具的土壤相关联的载荷力的系统和方法,所述土壤用于产生代表土壤物理特性的空间变异性的空间上可变的地图。 提供了一种被配置为测量负载力的仪表式挂钩销,用于测量农场工具在拖拉机连接并拉过或穿过土壤时由农用机械产生的负载力。 每次测量负载力时,全局定位系统都会识别测量的位置。 该数据被存储和分析以产生土壤的空间可变的图。 该图表示土体的物理特性,这是根据载荷力的大小推断的。

    Leaf seals
    10.
    发明授权
    Leaf seals 失效
    叶密封

    公开(公告)号:US5118120A

    公开(公告)日:1992-06-02

    申请号:US632667

    申请日:1990-12-27

    IPC分类号: F01D11/00 F16J15/02

    CPC分类号: F01D11/005 F16J15/021

    摘要: An apparatus for effecting a seal between two structural components of a turbo machine or similar device comprises a leaf seal located in the space between the two components and a spring which continuously biases the leaf seal into a sealing position against the components regardless of the pressure differential across the leaf seal.

    摘要翻译: 用于在涡轮机或类似装置的两个结构部件之间实现密封的装置包括位于两个部件之间的空间中的叶片密封件以及弹簧,该弹簧连续地将叶片密封件偏压到与组件无关的密封位置,而与压差无关 穿过叶子密封。