公开(公告)号：US12037382B2

公开(公告)日：2024-07-16

申请号：US16967269

申请日：2019-02-05

Applicant: Stichting VU

Inventor： Martine Joyce Smit ,  Raimond Heukers ,  Timo Werner Marcella De Groof ,  Tian Shu Fan ,  Raymond Henry De Wit

IPC: A61K47/68 ,  A61K41/00 ,  C07K16/08 ,  C07K16/18 ,  G01N33/574

CPC classification number: C07K16/085 ,  A61K41/0057 ,  A61K47/6839 ,  A61K47/6865 ,  C07K16/18 ,  G01N33/57492 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  G01N2333/045

Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.

公开(公告)号：US20240309071A1

公开(公告)日：2024-09-19

申请号：US18736952

申请日：2024-06-07

Applicant: Stichting VU

Inventor： Martine Joyce Smit ,  Raimond Heukers ,  Timo Werner Marcella De Groof ,  Tian Shu Fan ,  Raymond Henry De Wit

IPC: C07K16/08 ,  A61K41/00 ,  A61K47/68 ,  C07K16/18 ,  G01N33/574

CPC classification number: C07K16/085 ,  A61K41/0057 ,  A61K47/6839 ,  A61K47/6865 ,  C07K16/18 ,  G01N33/57492 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/569 ,  C07K2317/92 ,  G01N2333/045

Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.

公开(公告)号：US20220324947A1

公开(公告)日：2022-10-13

申请号：US17632023

申请日：2020-08-05

Applicant: Stichting VU ,  Cambridge Enterprise Limited

Inventor： Martine Joyce Smit ,  Timo Werner Marcella De Groof ,  Raimond Heukers ,  John Sinclair ,  Elizabeth Elder

IPC: C07K16/08 ,  C12N7/00 ,  G01N33/50

Abstract: The invention relates to the use of a single heavy chain variable domain antibody against human cytomegalovirus protein US28, which antibody binds to the extracellular region including, for example, the N-terminal extracellular region and/or the extracellular loops of US28, for isolation of cells that are infected with cytomegalovirus and/or for ex vivo reactivation of cytomegalovirus in latently infected cells. The invention further relates to the anti-US28 antibody for use in a method of reactivating cytomegalovirus in infected cells, or in a method of eliminating infected cells. The invention further relates to a tissue, organ, or cells such as bone marrow stem cells, from which cells that were infected with CMV have been removed with the use of the anti-US28 antibody.

公开(公告)号：US20210032316A1

公开(公告)日：2021-02-04

申请号：US16967269

申请日：2019-02-05

Applicant: Stichting VU

Inventor： Martine Joyce Smit ,  Raimond Heukers ,  Timo Werner Marcella De Groof ,  Tian Shu Fan ,  Raymond Henry De Wit

IPC: C07K16/08 ,  C07K16/18 ,  G01N33/574 ,  A61K47/68 ,  A61K41/00

Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.