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公开(公告)号：US12037382B2
公开(公告)日：2024-07-16
申请号：US16967269
申请日：2019-02-05
Applicant: Stichting VU
Inventor： Martine Joyce Smit , Raimond Heukers , Timo Werner Marcella De Groof , Tian Shu Fan , Raymond Henry De Wit
IPC: A61K47/68 , A61K41/00 , C07K16/08 , C07K16/18 , G01N33/574
CPC classification number: C07K16/085 , A61K41/0057 , A61K47/6839 , A61K47/6865 , C07K16/18 , G01N33/57492 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N2333/045
Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.
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公开(公告)号：US11839525B2
公开(公告)日：2023-12-12
申请号：US15572617
申请日：2016-05-04
Applicant: Stichting VU
Inventor： Daniel Wismeijer
IPC: A61C8/00 , A61C13/00 , A61C1/08 , A61C3/02 , B33Y50/00 , B33Y80/00 , A61B5/055 , A61B6/03 , A61C9/00 , G16H20/40 , B28B1/00
CPC classification number: A61C8/0089 , A61B5/055 , A61B6/032 , A61C1/084 , A61C3/02 , A61C9/004 , A61C13/0004 , B33Y50/00 , B33Y80/00 , B28B1/001 , G16H20/40
Abstract: Method of customizing and manufacturing tooling for preparing an osteotomy for receiving a dental implant, in particular drills and/or osteotomes. The method comprises the steps of: —receiving scan data modeling a planned position of the osteotomy and surrounding jaw bone area; —generating on the basis of the scan data a virtual implant model of the dental implant; —generating a virtual tooling model of the tooling on basis of the virtual implant model; —computer aided manufacturing of the tooling on the basis of the virtual tooling model.
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公开(公告)号：US20210080394A1
公开(公告)日：2021-03-18
申请号：US16967111
申请日：2019-02-05
Applicant: LUMICKS TECHNOLOGIES B.V. , STICHTING VU
Inventor： Iddo Heller , Anna Elisabeth Christina MEIJERING , Gijs Jan Lodewijk WUITE , Erwin Johannes Gerard PETERMAN , Andreas Sebastian BIEBRICHER
Abstract: One aspect of this disclosure relates to a method for determining a presence of at least one guest structure at a host structure. The method comprises a light-sensitive system receiving light from the host structure. The host structure hosts one or more optically active entities at at least one part of the host structure. Herein, the at least one part does not host the at least one guest structure. Furthermore, the optically active entities cause light emission from said at least one part. The method also comprises the light-sensitive system outputting a signal based on the received light. The method further comprises determining a light value based on the output signal. The light value indicates an amount of light from the host structure being incident on the light-sensitive system. The method also comprises determining on the basis of the light value at least one of a quantity and a position of the at least one guest structure at the host structure.
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公开(公告)号：US10101338B2
公开(公告)日：2018-10-16
申请号：US14570076
申请日：2014-12-15
Applicant: Cambridge Enterprise Limited , Stichting VU
Inventor： Sabine Bahn , Emanuel Schwarz , Brenda Penninx , Nicole Vogelzangs
IPC: A01N37/18 , G01N33/53 , G01N33/68 , G01N33/573
Abstract: The invention relates to biomarkers and a method of diagnosing or monitoring depression, anxiety disorder or other psychotic disorder.
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公开(公告)号：US09952421B2
公开(公告)日：2018-04-24
申请号：US15549832
申请日：2016-02-04
Applicant: Stichting Vu
Inventor： Andreas Sebastian Biebricher , Andrea Candelli , Iddo Heller , Niels Laurens , Erwin Johannes Gerard Peterman , Gijs Jan Lodewijk Wuite
IPC: G02B21/32 , G02B27/14 , G02B26/08 , G02B27/28 , G02B21/16 , G02B21/18 , G02B21/36 , G01N21/64 , B01L3/00 , G02B27/10
CPC classification number: G02B21/32 , B01L3/50273 , B01L3/502761 , B01L2200/0663 , B01L2300/0654 , B01L2400/0454 , G01N21/6428 , G01N21/6458 , G01N2021/6439 , G02B21/16 , G02B21/18 , G02B21/361 , G02B26/0816 , G02B27/106 , G02B27/141 , G02B27/283
Abstract: The present disclosure relates to an apparatus (100) and method for controlling a plurality of simultaneously active optical traps (OT1,OT2,OT3). In one method, trapping beams (TB1,TB2,TB3) are provided and redirected for individually controlling a respective position (X,Y) of optical traps (OT1,OT2,OT3) formed by focusing of the redirected trapping beams in a sample volume (SV). Light (L11,L20) from the sample volume (SV) corresponding to the optical traps is received. A path of a detector beam (AB) is overlapped with one of the trapping beams (TB3), wherein the detector beam has a distinct wavelength (λA) from that of the overlapping trapping beam (TB3). In one channel, the light from the sample volume is filtered according to wavelength, and only the filtered light having the wavelength (λA) of the detector beam (AB) is measured.
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Patent Agency Ranking
公开(公告)号：US20180024342A1
公开(公告)日：2018-01-25
申请号：US15549832
申请日：2016-02-04
Applicant: Stichting Vu
Inventor： Andreas Sebastian Biebricher , Andrea Candelli , Iddo Heller , Niels Laurens , Erwin Johannes Gerard Peterman , Gijs Jan Lodewijk Wuite
IPC: G02B21/32 , G02B27/14 , G02B26/08 , B01L3/00 , G02B21/16 , G02B21/18 , G02B21/36 , G01N21/64 , G02B27/10 , G02B27/28
CPC classification number: G02B21/32 , B01L3/50273 , B01L3/502761 , B01L2200/0663 , B01L2300/0654 , B01L2400/0454 , G01N21/6428 , G01N21/6458 , G01N2021/6439 , G02B21/16 , G02B21/18 , G02B21/361 , G02B26/0816 , G02B27/106 , G02B27/141 , G02B27/283
Abstract: The present disclosure relates to an apparatus (100) and method for controlling a plurality of simultaneously active optical traps (OT1, OT2, OT3). In one method, trapping beams (TB1, TB2, TB3) are provided and redirected for individually controlling a respective position (X,Y) of optical traps (OT1, OT2, OT3) formed by focusing of the redirected trapping beams in a sample volume (SV). Light (L11,L20) from the sample volume (SV) corresponding to the optical traps is received. A path of a detector beam (AB) is overlapped with one of the trapping beams (TB3), wherein the detector beam has a distinct wavelength (λA) from that of the overlapping trapping beam (TB3). In one channel, the light from the sample volume is filtered according to wavelength, and only the filtered light having the wavelength (λA) of the detector beam (AB) is measured.
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公开(公告)号：US20150099663A1
公开(公告)日：2015-04-09
申请号：US14570076
申请日：2014-12-15
Applicant: Cambridge Enterprise Limited , Stichting VU-VUMC
Inventor： Sabine Bahn , Emanuel Schwarz , Brenda Pennix , Nicole Vogelzangs
IPC: G01N33/68 , G01N33/573
CPC classification number: G01N33/6869 , G01N33/573 , G01N33/68 , G01N33/6863 , G01N33/6866 , G01N2333/435 , G01N2333/525 , G01N2333/54 , G01N2333/5403 , G01N2333/5406 , G01N2333/5409 , G01N2333/5412 , G01N2333/5418 , G01N2333/5421 , G01N2333/5428 , G01N2333/55 , G01N2333/555 , G01N2333/57 , G01N2333/96494 , G01N2800/30 , G01N2800/301
Abstract: The invention relates to biomarkers and a method of diagnosing or monitoring depression, anxiety disorder or other psychotic disorder.
Abstract translation: 本发明涉及生物标志物和诊断或监测抑郁症，焦虑障碍或其它精神病症的方法。
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公开(公告)号：US20240309071A1
公开(公告)日：2024-09-19
申请号：US18736952
申请日：2024-06-07
Applicant: Stichting VU
Inventor： Martine Joyce Smit , Raimond Heukers , Timo Werner Marcella De Groof , Tian Shu Fan , Raymond Henry De Wit
IPC: C07K16/08 , A61K41/00 , A61K47/68 , C07K16/18 , G01N33/574
CPC classification number: C07K16/085 , A61K41/0057 , A61K47/6839 , A61K47/6865 , C07K16/18 , G01N33/57492 , C07K2317/31 , C07K2317/565 , C07K2317/569 , C07K2317/92 , G01N2333/045
Abstract: The invention relates to a novel class of antagonistic and inverse agonistic anti-US28 antibodies, more specifically to single heavy chain variable domain antibodies (VHH) and variants and modifications thereof. The invention further relates to methods for producing these antibodies and to the use of the antibodies in methods for diagnostic and therapeutic purposes, especially for treatment of an individual suffering from a CMV-positive tumor such as glioblastoma.
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公开(公告)号：US11972031B2
公开(公告)日：2024-04-30
申请号：US17775322
申请日：2020-11-03
Applicant: KONINKLIJKE PHILIPS N.V. , Stichting VU
Inventor： Hendrik Jaap Bos , Elias Athanasopoulos , Radhesh Krishnan Konoth , Kaveh Razavi
CPC classification number: G06F21/72 , G06F21/34 , G06F21/606 , G06F21/74 , G06F21/84
Abstract: Some embodiments are directed to secure communication with a server from a device. The device is configured to decrypt an encrypted message in a secure mode with a private key, and to display secret shared with the user together with the decrypted message on a display of the device to indicate to the user that the message is being displayed by software running in the secure mode.
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公开(公告)号：US20220391543A1
公开(公告)日：2022-12-08
申请号：US17775322
申请日：2020-11-03
Applicant: KONINKLIJKE PHILIPS N.V. , Stichting VU
Inventor： Hendrik Jaap BOS , Elias ATHANASOPOULOS , Radhesh Krishnan KONOTH , Kaveh RAZAVI
Abstract: Some embodiments are directed to secure communication with a server from a device. The device is configured to decrypt an encrypted message in a secure mode with a private key, and to display secret shared with the user together with the decrypted message on a display of the device to indicate to the user that the message is being displayed by software running in the secure mode.
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