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公开(公告)号：US08399233B2
公开(公告)日：2013-03-19
申请号：US10919217
申请日：2004-08-16
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
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公开(公告)号：US08329946B2
公开(公告)日：2012-12-11
申请号：US13221602
申请日：2011-08-30
IPC分类号： C07C259/04 , A61K31/19
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
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公开(公告)号：US08329945B2
公开(公告)日：2012-12-11
申请号：US13221561
申请日：2011-08-30
IPC分类号： C07C259/04 , A61K31/19
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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公开(公告)号：US20120302510A1
公开(公告)日：2012-11-29
申请号：US13566803
申请日：2012-08-03
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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公开(公告)号：US20110313045A1
公开(公告)日：2011-12-22
申请号：US13221561
申请日：2011-08-30
IPC分类号： A61K31/16 , C07C259/06 , A61P35/00 , C12N5/071
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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公开(公告)号：US06777217B1
公开(公告)日：2004-08-17
申请号：US08624735
申请日：1996-03-26
IPC分类号： C12N912
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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公开(公告)号：US20110319493A1
公开(公告)日：2011-12-29
申请号：US13221602
申请日：2011-08-30
IPC分类号： A61K31/165 , C07C259/06 , A61P35/00 , C12N5/071
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
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公开(公告)号：US07994362B2
公开(公告)日：2011-08-09
申请号：US12196878
申请日：2008-08-22
IPC分类号： C07C259/04 , A61K31/19
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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公开(公告)号：US08426592B2
公开(公告)日：2013-04-23
申请号：US13566803
申请日：2012-08-03
IPC分类号： C07D239/02 , A61K31/505
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
摘要翻译： 本发明涉及由一系列基因（称为HDx相关基因）编码的蛋白质的发现，其涉及染色质结构的控制，因此涉及转录和翻译。 本发明提供可用于例如在体外和体内控制细胞增殖和分化的组合物和方法。
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公开(公告)号：US08362084B2
公开(公告)日：2013-01-29
申请号：US13030086
申请日：2011-02-17
IPC分类号： A61K31/19
CPC分类号： C12N9/80 , A01K2217/05 , A01K2217/075 , A61K31/00 , A61K31/165 , A61K31/407 , A61K38/00 , A61K48/00 , C07K5/126 , C07K14/4702 , C07K14/4703 , C07K2319/00 , C12N9/16
摘要： The present invention concerns the discovery that proteins encoded by a family of genes, termed here HDx-related genes, which are involved in the control of chromatin structure and, thus in transcription and translation. The present invention makes available compositions and methods that can be utilized, for example to control cell proliferation and differentiation in vitro and in vivo.
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