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    TRANSORAL DOSAGE FORMS COMPRISING SUFENTANIL AND NALOXONE
    1.
    发明申请
    TRANSORAL DOSAGE FORMS COMPRISING SUFENTANIL AND NALOXONE 审中-公开
    包含SUFENTANIL和NALOXONE的转运剂型

    公开(公告)号：US20100010031A1

    公开(公告)日：2010-01-14

    申请号：US12449292

    申请日：2008-02-08

    申请人： Su Yum, II ,  Jaymin Shah ,  Sung Yun Kwon ,  Xiaoping Song

    发明人： Su Yum, II ,  Jaymin Shah ,  Sung Yun Kwon ,  Xiaoping Song

    IPC分类号： A61K31/4535 ,  A61K31/485

    CPC分类号： A61K31/4535 ,  A61K9/0056 ,  A61K9/006 ,  A61K9/06 ,  A61K9/2009 ,  A61K9/2063 ,  A61K9/7007 ,  A61K31/485 ,  A61K2300/00

    摘要： The invention pertains to methods that include administering to a subject a transoral dosage form comprising a pharmaceutical carrier and sufentanil, and maintaining a mean pH ranging from about 3.5 to about 5.5 during a dosing period after administration of the transoral dosage form as determined using an in vitro donor media test. Related dosage forms are also disclosed. Also disclosed are transoral dosage forms and related methods, wherein a transoral dosage form may comprise: (1) about 5 to about 1000 micrograms of sufentanil; (2) about 50 micrograms to about 100 milligrams of naloxone; and (3) acidifying material in an amount sufficient to provide a mean pH ranging from about 3.5 to about 5.5 during a dosing period after administration of the transoral dosage form as determined using an in vitro donor media test; wherein the dosing period begins no earlier than about 1 minute after administration of the transoral dosage form, and ends no later than about 120 minutes after administration of the transoral dosage form.

    摘要翻译： 本发明涉及包括向受试者施用包含药物载体和舒芬太尼的经口给药形式的方法，并且在给予经口给药后的给药期间保持约3.5至约5.5的平均pH，所述给药期间使用 体外供体介质试验。 还公开了相关的剂型。 还公开了经口给药剂型和相关方法，其中经口剂型可包含：（1）约5至约1000微克的舒芬太尼; （2）约50微克至约100毫克的纳洛酮; 和（3）足量的酸化材料，其在施用经口给药形式后的给药期间提供约3.5至约5.5的平均pH，使用体外供体培养基测试确定; 其中给药期在给予经口给药后不早于约1分钟开始，并且在给予经口给药后不迟于约120分钟结束。

    SHORT-CIRCUIT-PROOF HEAT-EXCHANGER WITH HELICAL BAFFLES
    4.
    发明申请
    SHORT-CIRCUIT-PROOF HEAT-EXCHANGER WITH HELICAL BAFFLES 审中-公开
    短路电流互感器，带有螺纹焊接

    公开(公告)号：US20100193167A1

    公开(公告)日：2010-08-05

    申请号：US12597070

    申请日：2007-11-26

    申请人： Xiaoping Song ,  Zhizhong Pei

    发明人： Xiaoping Song ,  Zhizhong Pei

    IPC分类号： F28D7/10

    CPC分类号： F28F9/22 ,  F28D7/16 ,  F28F27/02 ,  F28F2009/228 ,  Y02P20/124

    摘要： The present invention relates to a short-circuit-proof heat-exchanger with helical baffles, which comprises a housing, helical baffles and heat exchange tubes extending through the helical baffles, wherein two straight sides of the sector baffles with a projection of 360°/4 are respectively widened and overlap in turn, and the heat exchange tubes pass through the overlapping parts. The present invention is characterized in that the short-circuit-proof heat-exchanger with helical baffles also comprises pull rods, wherein one pull rod is positioned on the central axis of the housing and extends through the widened overlapping parts of the helical baffles, and the other pull rods extend through both end areas of the central line of the projection of the widened overlapping parts of the helical baffles; one end of each pull rod is fixed to the internal surface of a tube sheet arranged at one end of the housing, and the other end is fixed to the last corresponding helical baffle; distance tubes are segmentally sheathed on the pull rods. The present invention has the advantages of reasonable structure, increased heat exchange efficiency, enhanced integral rigidity and shockproof performance, simplified assembly technology, saved cost and increased work efficiency. The shell-tube heat exchanger with helical baffles can be extensively used in the technical processes of petroleum industry, chemical industry, power generation industry, metallurgical industry, food industry, pharmaceutical industry, etc.

    摘要翻译： 本发明涉及一种具有螺旋挡板的防短路热交换器，其包括壳体，螺旋挡板和延伸穿过螺旋挡板的热交换管，其中扇形挡板的两个直边具有360°/ 4分别加宽并重叠，并且热交换管穿过重叠部分。 本发明的特征在于具有螺旋挡板的防短路热交换器还包括拉杆，其中一个拉杆定位在壳体的中心轴线上并延伸穿过螺旋挡板的加宽的重叠部分，并且 另一个拉杆延伸穿过螺旋挡板的加宽的重叠部分的突起的中心线的两个端部区域; 每个拉杆的一端固定在布置在壳体的一端的管板的内表面，另一端固定到最后相应的螺旋挡板上; 距离管在拉杆上分段包扎。 本发明具有结构合理，热交换效率高，整体刚性好，防震性能好，组装技术简化，节省成本，提高工作效率的优点。 具有螺旋挡板的壳管换热器可广泛应用于石油工业，化工，发电行业，冶金工业，食品工业，制药工业等技术过程。