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47 条记录 (耗时 0.035 秒)

    Self adjustable exit port
    5.
    发明授权
    Self adjustable exit port 有权
    自调节出口

    公开(公告)号：US06217906B1

    公开(公告)日：2001-04-17

    申请号：US09397507

    申请日：1999-09-17

    申请人： Juan C. Gumucio ,  Keith E. Dionne ,  James E. Brown

    发明人： Juan C. Gumucio ,  Keith E. Dionne ,  James E. Brown

    IPC分类号： A23K118

    CPC分类号： A61K9/0004

    摘要： A delivery device having a first chamber containing an osmotic agent, a membrane forming a wall of the first chamber through which fluid is imbibed by osmosis, a second chamber containing a beneficial agent to be delivered, and a moveable piston separating the two chambers. In fluid communication with the second chamber is an orifice which comprises a slit valve. In the presence of pressure, the beneficial agent pushes through the slit, opening up a channel for delivery of the beneficial agent and creating flow. Because the slit remains closed in the absence of flow (or when the pressure is below the pressure required to open the slit), back diffusion of external fluids is eliminated when the slit is closed, which prevents contamination of the beneficial agent in the second chamber by external fluids. In addition, forward diffusion of the beneficial agent out of the capsule is prevented when the slit is closed. The slit valve opens only to the minimum dimension required to allow the flow generated by the osmotic pumping rate. The slit valve also allows a flow path to open around any obstruction in the slit valve to prevent clogging.

    摘要翻译： 一种输送装置，具有含有渗透剂的第一室，形成第一室的壁的膜，通过渗透吸入流体的第一室;含有要输送的有益剂的第二室和分离两个室的活动活塞。 与第二腔室流体连通的是包括狭缝阀的孔口。 在存在压力的情况下，有益剂推动狭缝，打开用于输送有益剂并产生流动的通道。 因为缝隙在没有流动的情况下保持关闭（或当压力低于打开狭缝所需的压力时），当狭缝闭合时，外部流体的反向扩散被消除，这防止有益剂在第二腔室中的污染 通过外部流体。 此外，当狭缝闭合时，防止有益剂从胶囊中向前扩散。 狭缝阀仅打开允许由渗透泵送速率产生的流量所需的最小尺寸。 狭缝阀还允许流动通道围绕狭缝阀中的任何阻塞开放以防止堵塞。

    Directional drug delivery stent and method of use
    6.
    发明授权
    Directional drug delivery stent and method of use 失效
    定向药物输送支架及其使用方法

    公开(公告)号：US6071305A

    公开(公告)日：2000-06-06

    申请号：US976725

    申请日：1997-11-24

    申请人： James E. Brown ,  Wouter E. Roorda

    发明人： James E. Brown ,  Wouter E. Roorda

    IPC分类号： A61F2/00 ,  A61F2/82 ,  A61F2/88 ,  A61F2/91 ,  A61F2/915 ,  A61L33/00 ,  A61L33/06 ,  A61L33/08 ,  A61F2/06

    CPC分类号： A61F2/82 ,  A61F2/88 ,  A61F2/91 ,  A61F2/915 ,  A61L33/0005 ,  A61L33/0011 ,  A61L33/0064 ,  A61L33/066 ,  A61L33/068 ,  A61L33/08 ,  A61F2002/91541 ,  A61F2240/001 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61M2005/14513

    摘要： The invention relates to a directional drug delivery stent which includes an elongated or tubular member having a cavity containing a biologically active agent. In one embodiment, the active agent is diffused from the reservoir directly to the walls of a body lumen, such as a blood vessel, through directional delivery openings arranged on an outer surface of the elongated member. Another variation of the stent includes an osmotic engine assembly for controlling the delivery of the active agent from the reservoir. The drugs which may be applied by the directional delivery stent include, but are not limited to, steroids, anti-inflammatory agents, restenosis preventing drugs, anti-thrombotic drugs, and tissue growth regulating drugs. The invention also relates to a method of using the directional drug delivery stent.

    摘要翻译： 本发明涉及定向药物递送支架，其包括具有包含生物活性剂的空腔的细长管状构件。 在一个实施方案中，活性剂通过布置在细长构件的外表面上的定向输送开口从储存器直接扩散到体腔（例如血管）的壁。 支架的另一变体包括渗透引擎组件，用于控制活性剂从贮存器的输送。 可以由定向递送支架施用的药物包括但不限于类固醇，抗炎剂，预防再狭窄药物，抗血栓形成药物和组织生长调节药物。 本发明还涉及使用定向药物输送支架的方法。

    Positive action gate clip
    7.
    发明授权
    Positive action gate clip 失效
    积极行动门夹

    公开(公告)号：US4654937A

    公开(公告)日：1987-04-07

    申请号：US817477

    申请日：1986-01-08

    申请人： James E. Brown

    发明人： James E. Brown

    IPC分类号： F16B45/04 ,  A44B21/00

    CPC分类号： F16B45/04 ,  Y10T24/44581 ,  Y10T24/45283 ,  Y10T24/45398

    摘要： A positive action gate clip comprising a frame having at least two parallel opposing sections, at least one section being discontinuous so as to provide a lower section and an upper section with a gap thereinbetween, a rod-like gate element, and means for retracting the gate element into the frame, the frame upper and lower sections having openings therein so as to permit the coaxial insertion of the gate element into and through the upper section and into the lower section so as to form a gate across the gap thereinbetween, the retracting means permitting the partial withdrawal of the gate element from the frame so as to withdraw the corresponding portion of the gate element from the lower section and from across the gap between the upper and lower sections by the application of force parallel to the motion of the gate element and away from the frame.

    摘要翻译： 一种积极动作门夹，包括具有至少两个平行相对部分的框架，至少一个部分是不连续的，以便提供一个下部分和一个在其间具有间隙的上部部分，一个棒状门元件，以及用于缩回 门元件插入框架中，框架上部和下部具有开口，以允许栅极元件同时插入并穿过上部并进入下部，以便在其间形成跨过其间的间隙，缩回 意味着允许栅极元件从框架中部分抽出，以便通过施加平行于门的运动的力从该下部突出并且从上部和下部之间的间隙中延伸出栅极元件的对应部分 元素并远离框架。

    Human support apparatus
    8.
    发明授权
    Human support apparatus 失效
    人体支持装置

    公开(公告)号：US4154233A

    公开(公告)日：1979-05-15

    申请号：US823727

    申请日：1977-08-11

    申请人： James E. Brown

    发明人： James E. Brown

    IPC分类号： A63B7/00 ,  A61H1/02

    CPC分类号： A63B7/00 ,  A63B2208/0285

    摘要： Apparatus for supporting humans in a vertical head-down position, including apparatus for climbing into position.

    摘要翻译： 用于支撑人类处于垂直向下位置的装置，包括用于爬升到位的装置。