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公开(公告)号：US20080051398A1
公开(公告)日：2008-02-28
申请号：US11773285
申请日：2007-07-03
IPC分类号： A61K31/5377 , A61K31/4709 , A61P25/00 , A61P35/00 , A61K31/517
CPC分类号： A61K31/4709 , A61K31/517 , A61K31/5377
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs, and in particular to the use of these compounds in treating brain cancer.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症，特别是这些化合物在治疗脑癌中的用途。
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2.发明申请PHARMACEUTICAL COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF 失效作为杀虫剂和杀虫剂的激活剂的药物化合物及其用途公开(公告)号：US20080020985A1
公开(公告)日：2008-01-24
申请号：US11773293
申请日：2007-07-03
申请人： Sui Xiong Cai , Mark Anderson , Adam Willardsen , Songchun Jiang , Robert Halter , Rachel Slade , Yevgeniya Klimova
发明人： Sui Xiong Cai , Mark Anderson , Adam Willardsen , Songchun Jiang , Robert Halter , Rachel Slade , Yevgeniya Klimova
IPC分类号： A61K31/53 , A61K31/502 , A61K31/66 , A61K31/704 , A61K31/7076 , A61K38/08 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , C07D237/34 , C07D253/08
CPC分类号： C07D237/34 , C07D253/08
摘要： Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了1-芳基氨基 - 酞嗪，4-芳基氨基 - 苯并[d] [1,2,3]三嗪及其类似物作为胱天蛋白酶的活化剂和凋亡诱导剂。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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公开(公告)号：US20080004297A1
公开(公告)日：2008-01-03
申请号：US11773303
申请日：2007-07-03
申请人： Sui Cai , Mark Anderson , Adam Willardsen , Nilantha Sirisoma , Hong Zhang , Kazuyuki Suzuki
发明人： Sui Cai , Mark Anderson , Adam Willardsen , Nilantha Sirisoma , Hong Zhang , Kazuyuki Suzuki
IPC分类号： A61K31/517 , A61P31/10 , A61P31/12 , A61P35/00 , A61P37/00 , C07D239/84 , C07D239/94 , C07D401/12 , C07D403/12
CPC分类号： C07D239/94 , C07D239/72 , C07D403/12
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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公开(公告)号：US08258145B2
公开(公告)日：2012-09-04
申请号：US11773285
申请日：2007-07-03
IPC分类号： A61K31/517 , A61K31/535 , A61K31/47
CPC分类号： A61K31/4709 , A61K31/517 , A61K31/5377
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs, and in particular to the use of these compounds in treating brain cancer.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗发生异常细胞的不受控制的生长和扩散的各种临床病症，特别是这些化合物在治疗脑癌中的用途。
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5.发明授权4-arylamin-or-4-heteroarylamino-quinazolines and analogs as activators of caspases and inducers of apoptosis and the use thereof 失效4-芳基氨基 - 或 - 4-杂芳基氨基 - 喹唑啉及其类似物作为胱天蛋白酶的活化剂和凋亡诱导剂及其用途公开(公告)号：US07989462B2
公开(公告)日：2011-08-02
申请号：US11773303
申请日：2007-07-03
申请人： Sui Xiong Cai , Mark B. Anderson , Adam Willardsen , Nilantha Sudath Sirisoma , Hong Zhang , Kazuyuki Suzuki
发明人： Sui Xiong Cai , Mark B. Anderson , Adam Willardsen , Nilantha Sudath Sirisoma , Hong Zhang , Kazuyuki Suzuki
IPC分类号： A01N43/90 , A61K31/519 , C07D401/00 , C07D403/00 , C07D413/00 , C07D417/00 , C07D419/00 , C07D239/02
CPC分类号： C07D239/94 , C07D239/72 , C07D403/12
摘要： Disclosed are 4-arylamino-quinazolines and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了作为胱天蛋白酶的活化剂和凋亡诱导剂的4-芳基氨基 - 喹唑啉及其类似物。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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6.发明授权Pharmaceutical compounds as activators of caspases and inducers of apoptosis and the use thereof 失效药物化合物作为胱天蛋白酶的活化剂和凋亡诱导剂及其用途公开(公告)号：US07842805B2
公开(公告)日：2010-11-30
申请号：US11773293
申请日：2007-07-03
申请人： Sui Xiong Cai , Mark B. Anderson , Adam Willardsen , Songchun Jiang , Robert J. Halter , Rachel Slade , Yevgeniya Klimova
发明人： Sui Xiong Cai , Mark B. Anderson , Adam Willardsen , Songchun Jiang , Robert J. Halter , Rachel Slade , Yevgeniya Klimova
IPC分类号： C07D403/12 , C07D253/08 , A61K31/53 , A61P35/00
CPC分类号： C07D237/34 , C07D253/08
摘要： Disclosed are 1-arylamino-phthalazines, 4-arylamino-benzo[d][1,2,3]triazines, and analogs thereof effective as activators of caspases and inducers of apoptosis. The compounds of this invention are useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
摘要翻译： 公开了1-芳基氨基 - 酞嗪，4-芳基氨基 - 苯并[d] [1,2,3]三嗪及其类似物作为胱天蛋白酶的活化剂和凋亡诱导剂。 本发明的化合物可用于治疗异常细胞发生不受控制的生长和扩散的各种临床病症。
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公开(公告)号：US20100093773A1
公开(公告)日：2010-04-15
申请号：US12574632
申请日：2009-10-06
IPC分类号： A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , C07D239/94
摘要： Disclosed is (4-Methoxy-phenyl)-methyl-(2-methyl-quinazolin-4-yl)-amine hydrochloride effective as a vascular disrupting agent. (4-Methoxy-phenyl)-methyl-(2-methyl-quinazolin-4-yl)-amine hydrochloride is useful in the treatment of a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs, and in particular to its use in treating cancer.
摘要翻译： 公开了作为血管破坏剂有效的（4-甲氧基 - 苯基） - 甲基 - （2-甲基 - 喹唑啉-4-基） - 胺盐酸盐。 （4-甲氧基 - 苯基） - 甲基 - （2-甲基 - 喹唑啉-4-基） - 胺盐酸盐可用于治疗异常细胞发生不受控生长和扩散的各种临床病症，特别是 其用于治疗癌症。
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