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公开(公告)号：US20080039366A1
公开(公告)日：2008-02-14
申请号：US11436404
申请日：2006-05-18
CPC分类号： A61K9/0075 , A61K9/1617 , A61K38/28 , A61K47/544 , Y10S514/958
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
摘要翻译： 本发明一般涉及将治疗性预防和诊断试剂肺部递送给患者，其中药剂以持续方式释放，以及适用于该方法的颗粒。 特别地，本发明涉及用于肺部递送治疗性，预防性或诊断性药物的方法，其包括对需要治疗，预防或诊断的患者的呼吸道施用有效量的包含治疗性，预防性或诊断性的颗粒 药剂或其任何组合与带电脂质相结合，其中带电脂质具有与药剂相关的与药剂相反的总净电荷。 药剂从给药颗粒中的释放以持续的方式发生。
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公开(公告)号：US07048908B2
公开(公告)日：2006-05-23
申请号：US10202616
申请日：2002-07-23
CPC分类号： A61K9/0075 , A61K9/1617 , A61K38/28 , A61K47/544 , Y10S514/958
摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.
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公开(公告)号：US20050003003A1
公开(公告)日：2005-01-06
申请号：US10425194
申请日：2003-04-28
申请人： Sujit Basu , Giovanni Caponetti , Daniel Deaver , Katharina Elbert , Jeffrey Hrkach , Michael Lipp
发明人： Sujit Basu , Giovanni Caponetti , Daniel Deaver , Katharina Elbert , Jeffrey Hrkach , Michael Lipp
IPC分类号： A61K9/16 , A61K9/00 , A61K9/26 , A61K9/72 , A61K31/135 , A61K31/137 , A61K31/566 , A61K38/00 , A61K45/00 , A61K47/12 , A61K47/14 , A61K47/18 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/30 , A61K47/36 , A61K47/42 , A61P11/06 , A61K9/14
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/1617 , A61K31/135 , A61K31/137 , A61K2300/00
摘要： Particles which include a bioactive agent are prepared to have a desired matrix transition temperature. Delivery of the particles via the pulmonary system results in modulation of drug release from the particles. Sustained release and/or sustained pharmacologic action of the drug can be obtained by forming particles which include a combination of phospholipids that are miscible in one another and have a high matrix transition temperature.
摘要翻译： 制备包含生物活性剂的颗粒具有所需的基质转变温度。 通过肺系统递送颗粒导致药物从颗粒释放的调节。 药物的持续释放和/或持续的药物作用可以通过形成包含相互混溶并具有高基质转变温度的磷脂组合的颗粒来获得。
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