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    Particles for inhalation having sustained release properties
    1.
    发明申请
    Particles for inhalation having sustained release properties 审中-公开
    具有持续释放性质的吸入颗粒

    公开(公告)号：US20080039366A1

    公开(公告)日：2008-02-14

    申请号：US11436404

    申请日：2006-05-18

    申请人： Sujit K. Basu ,  Jeffrey Hrkach ,  Michael Lipp ,  Katharina Elbert ,  David A. Edwards

    发明人： Sujit K. Basu ,  Jeffrey Hrkach ,  Michael Lipp ,  Katharina Elbert ,  David A. Edwards

    IPC分类号： A61K38/28 ,  A61P3/00

    CPC分类号： A61K9/0075 ,  A61K9/1617 ,  A61K38/28 ,  A61K47/544 ,  Y10S514/958

    摘要： The invention generally relates to a method for pulmonary delivery of therapeutic, prophylactic and diagnostic agents to a patient wherein the agent is released in a sustained fashion, and to particles suitable for use in the method. In particular, the invention relates to a method for the pulmonary delivery of a therapeutic, prophylactic or diagnostic agent comprising administering to the respiratory tract of a patient in need of treatment, prophylaxis or diagnosis an effective amount of particles comprising a therapeutic, prophylactic or diagnostic agent or any combination thereof in association with a charged lipid, wherein the charged lipid has an overall net charge which is opposite to that of the agent upon association with the agent. Release of the agent from the administered particles occurs in a sustained fashion.

    摘要翻译： 本发明一般涉及将治疗性预防和诊断试剂肺部递送给患者，其中药剂以持续方式释放，以及适用于该方法的颗粒。 特别地，本发明涉及用于肺部递送治疗性，预防性或诊断性药物的方法，其包括对需要治疗，预防或诊断的患者的呼吸道施用有效量的包含治疗性，预防性或诊断性的颗粒 药剂或其任何组合与带电脂质相结合，其中带电脂质具有与药剂相关的与药剂相反的总净电荷。 药剂从给药颗粒中的释放以持续的方式发生。

    Aerodynamically light particles for pulmonary drug delivery
    4.
    发明申请
    Aerodynamically light particles for pulmonary drug delivery 审中-公开
    用于肺部药物递送的空气动力学轻微颗粒

    公开(公告)号：US20050244341A1

    公开(公告)日：2005-11-03

    申请号：US11177719

    申请日：2005-07-08

    申请人： David Edwards ,  Giovannia Caponetti ,  Jeffrey Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdell Ben-Jebria ,  Robert Langer

    发明人： David Edwards ,  Giovannia Caponetti ,  Jeffrey Hrkach ,  Noah Lotan ,  Justin Hanes ,  Abdell Ben-Jebria ,  Robert Langer

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K31/57 ,  A61K38/28 ,  A61K47/34 ,  A61L9/04 ,  G06F7/00 ,  G06F17/30

    CPC分类号： A61K31/57 ,  A61K9/0075 ,  A61K9/1647 ,  A61K9/1682 ,  A61K38/28 ,  A61K47/34 ,  G06F16/284

    摘要： Improved aerodynamically light particles for delivery to the pulmonary system, and methods for their preparation and administration are provided. In a preferred embodiment, the aerodynamically light particles are made of a biodegradable material and have a tap density less than 0.4 g/cm3 and a mass mean diameter between 5 μm and 30 μm. The particles may be formed of biodegradable materials such as biodegradable polymers. For example, the particles may be formed of a functionalized polyester graft copolymer consisting of a linear a-hydroxy-acid polyester backbone having at least one amino acid group incorporated herein and at least on poly(amino acid) side chain extending from an amino acid group in the polyester backbone. In one embodiment, aerodynamically light particles having a large mean diameter, for example greater than 5 μm, can be used for enhanced delivery of a therapeutic or diagnostic agent to the alveolar region of the lung. The aerodynamically light particles optionally can incorporate a therapeutic or diagnostic agent, and may be effectively aerosolized for administration to the respiratory tract to permit systemic or local delivery of a wide variety of incorporated agents.

    摘要翻译： 提供用于递送至肺系统的改善的空气动力学轻微颗粒，以及其制备和给药方法。 在优选的实施方案中，空气动力学轻微颗粒由可生物降解的材料制成，并且振实密度小于0.4g / cm 3，质量平均直径在5μm和30μm之间。 颗粒可以由可生物降解的材料如可生物降解的聚合物形成。 例如，颗粒可以由官能化的聚酯接枝共聚物形成，所述官能化聚酯接枝共聚物由具有至少一个引入本文的氨基酸基团和至少在从氨基酸延伸的聚（氨基酸）侧链上的直链α-羟基酸聚酯主链组成 集团在聚酯骨干。 在一个实施方案中，具有大平均直径（例如大于5μm）的空气动力学轻的颗粒可用于增强治疗或诊断剂递送至肺的肺泡区域。 空气动力学轻微颗粒任选地可以掺入治疗剂或诊断剂，并且可以有效地雾化用于给予呼吸道以允许各种并入药剂的全身或局部递送。

    Low dose pharmaceutical powders for inhalation
    5.
    发明申请
    Low dose pharmaceutical powders for inhalation 有权
    用于吸入的低剂量药物粉末

    公开(公告)号：US20050022812A1

    公开(公告)日：2005-02-03

    申请号：US10867375

    申请日：2004-06-14

    申请人： Jeffrey Hrkach

    发明人： Jeffrey Hrkach

    IPC分类号： A61K20060101 ,  A61M15/00 ,  A61M16/00

    CPC分类号： A61M15/0091 ,  A61K9/0075 ,  A61M15/0021 ,  A61M15/0028 ,  A61M15/0035 ,  A61M15/0041 ,  A61M15/0086 ,  A61M15/08 ,  A61M2202/064 ,  A61M2206/16 ,  A61M2209/02

    摘要： The invention relates to a method of delivering an agent to the pulmonary system of a compromised patient, in a single breath-activated step, comprising administering a particle mass comprising an agent from an inhaler containing less than 5 milligrams of the mass, wherein at least about 50% of the mass in the receptacle is delivered to the pulmonary system of a patient. The invention also relates to receptacles containing the particle mass and the inhaler for use therein.

    摘要翻译： 本发明涉及一种在单次呼吸激活步骤中将药剂递送至受损患者的肺系统的方法，包括从含有少于5毫克质量的吸入器施用包含药剂的颗粒物质，其中至少 容器中约50％的质量被输送到患者的肺部系统。 本发明还涉及包含用于其中的颗粒物质和吸入器的容器。

    Stable spray-dried protein formulations
    6.
    发明申请
    Stable spray-dried protein formulations 审中-公开
    稳定的喷雾干燥蛋白制剂

    公开(公告)号：US20060002996A1

    公开(公告)日：2006-01-05

    申请号：US11176841

    申请日：2005-07-07

    申请人： David Edwards ,  Jeffrey Hrkach

    发明人： David Edwards ,  Jeffrey Hrkach

    IPC分类号： A61K38/28 ,  A61K9/127

    CPC分类号： A61K9/0075 ,  A61K9/1617 ,  Y10S514/951 ,  Y10S514/97 ,  Y10S514/975

    摘要： Spray-dried particles having improved protein stability are produced by spray-drying a mixture including a protein, a phospholipid and an organic-aqueous co-solvent. Spray-dried particles which include at least 1 weight % phospholipid, having a tap density of less than 0.4 g/cm3 can be prepared. The particles can be delivered to the pulmonary system of a patient.

    摘要翻译： 具有改善的蛋白质稳定性的喷雾干燥颗粒通过喷雾干燥包括蛋白质，磷脂和有机 - 水性共溶剂的混合物而产生。 包含至少1重量％磷脂的喷雾干燥颗粒，其振实密度小于0.4g / cm 3，可以制备。 颗粒可以输送到患者的肺部系统。