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公开(公告)号：US20050059651A1
公开(公告)日：2005-03-17
申请号：US10492062
申请日：2002-10-15
申请人： Sula Armstrong , Dieter Hamprecht , Martin Jones , David Witty , Kamal Al-Barazanji , Mohammad Tadayyon
发明人： Sula Armstrong , Dieter Hamprecht , Martin Jones , David Witty , Kamal Al-Barazanji , Mohammad Tadayyon
IPC分类号： C07D209/48 , C07D239/91 , C07D239/96 , C07D257/12 , C07D495/04 , C07D513/04 , A61K31/55 , A61K31/40 , A61K31/445
CPC分类号： C07D209/48 , C07D239/91 , C07D239/96 , C07D257/12 , C07D495/04 , C07D513/04
摘要： The invention provides compounds of formula (I) a salt, or solvate thereof.
摘要翻译： 本发明提供式（I）化合物的盐或其溶剂合物。
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公开(公告)号：US20060287321A1
公开(公告)日：2006-12-21
申请号：US11466530
申请日：2006-08-23
申请人： Sula Armstrong , Dieter Hamprecht , Martin Jones , David Witty , Kamal Al-Baraznji , Mohammad Tadayyon
发明人： Sula Armstrong , Dieter Hamprecht , Martin Jones , David Witty , Kamal Al-Baraznji , Mohammad Tadayyon
IPC分类号： A61K31/53 , A61K31/519 , A61K31/517 , C07D498/02 , C07D487/02
CPC分类号： C07D209/48 , C07D239/91 , C07D239/96 , C07D257/12 , C07D495/04 , C07D513/04
摘要： The invention thus provides compounds of formula (I) a salt, or solvate thereof.
摘要翻译： 因此，本发明提供式（I）化合物的盐或其溶剂合物。
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公开(公告)号：US07220777B2
公开(公告)日：2007-05-22
申请号：US10492062
申请日：2002-10-15
申请人： Sula Anne Armstrong , Dieter Wolfgang Hamprecht , Martin Jones , David Richard Witty , Kamal A Al-Barazanji , Mohammad Tadayyon
发明人： Sula Anne Armstrong , Dieter Wolfgang Hamprecht , Martin Jones , David Richard Witty , Kamal A Al-Barazanji , Mohammad Tadayyon
IPC分类号： C07D403/10 , A61K31/4035 , A61P3/04 , A61P3/10 , A61P25/18 , A61P25/22 , A61P25/24
CPC分类号： C07D209/48 , C07D239/91 , C07D239/96 , C07D257/12 , C07D495/04 , C07D513/04
摘要： The invention provides compounds of formula (I) a salt, or solvate thereof.
摘要翻译： 本发明提供式（I）化合物的盐或其溶剂合物。
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4.发明申请公开(公告)号：US20110112069A1
公开(公告)日：2011-05-12
申请号：US12673176
申请日：2008-08-15
申请人： Frank Himmelsbach , Michael Mark , Mohammad Tadayyon , Leo Thomas
发明人： Frank Himmelsbach , Michael Mark , Mohammad Tadayyon , Leo Thomas
IPC分类号： A61K31/522 , A61K31/55 , A61K31/553 , A61K31/551 , A61K31/5377 , A61K31/5025 , A61K31/519 , A61P35/00 , A61P17/02 , A61P29/00
CPC分类号： A61K31/553 , A61K31/5025 , A61K31/517 , A61K31/522 , A61K31/55 , A61K31/551 , A61K31/5513 , A61P35/00
摘要： The specification describes the use of selected purine derivatives for the treatment of hyperproliferative diseases.
摘要翻译： 该说明书描述了所选嘌呤衍生物用于治疗过度增殖性疾病的用途。
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公开(公告)号：US07241579B2
公开(公告)日：2007-07-10
申请号：US10451007
申请日：2001-12-18
申请人： John Leon Andrews , Celia Patricia Briscoe , Diane Michele Ignar , Allison Isobel Muir , Howard Ray Sauls, Jr. , Mohammad Tadayyon
发明人： John Leon Andrews , Celia Patricia Briscoe , Diane Michele Ignar , Allison Isobel Muir , Howard Ray Sauls, Jr. , Mohammad Tadayyon
IPC分类号： G01N33/53 , G01N33/58 , G01N33/566
CPC分类号： G01N33/92 , C12Q1/6897
摘要： Methods of screening for ligands of the GPR40 receptor are provided, including methods utilizing fatty acid GPR40 ligands.
摘要翻译： 提供了筛选GPR40受体配体的方法，包括利用脂肪酸GPR40配体的方法。
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![Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions](/abs-image/US/2007/05/15/US07217711B2/abs.jpg.150x150.jpg)
6.发明授权Piperazin-1-yl and 2-([1,4]diazepan-1-yl)-imidazo[4,5-d]-pyridazin-4-ones, the preparation thereof and their use as pharmaceutical compositions 有权哌嗪-1-基和2 - （[1,4]二氮杂环庚烷-1-基） - 咪唑并[4,5-d] - 哒嗪-4-酮的制备及其作为药物组合物的用途公开(公告)号：US07217711B2
公开(公告)日：2007-05-15
申请号：US11016176
申请日：2004-12-17
申请人： Matthias Eckhardt , Norbert Hauel , Frank Himmelsbach , Iris Kauffmann-Hefner , Elke Langkopf , Mohammad Tadayyon , Leo Thomas
发明人： Matthias Eckhardt , Norbert Hauel , Frank Himmelsbach , Iris Kauffmann-Hefner , Elke Langkopf , Mohammad Tadayyon , Leo Thomas
IPC分类号： C07D487/04 , A61K31/5025 , A61P3/10
CPC分类号： C07D487/04
摘要： The present invention relates to substituted imidazo[4,5-d]pyridazin-4-ones of general formula wherein R1 to R3 and n are defined as in claims 1 to 8, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及以下通式的取代咪唑并[4,5-d]哒嗪-4-酮：其中R 1至R 3和n如权利要求1中所定义 至8，其互变异构体，对映异构体，非对映异构体，其混合物及其盐具有有价值的药理学性质，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用。
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7.发明授权Substituted imidazo-pyridinones and imidazo-pyridazinones, the preparation thereof and their use as pharmaceutical compositions 有权取代的咪唑并 - 吡啶酮和咪唑并哒嗪酮，其制备及其作为药物组合物的用途公开(公告)号：US07109192B2
公开(公告)日：2006-09-19
申请号：US10726214
申请日：2003-12-02
申请人： Norbert Hauel , Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Roland Maier , Michael Mark , Mohammad Tadayyon , Iris Kauffmann-Hefner
发明人： Norbert Hauel , Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Roland Maier , Michael Mark , Mohammad Tadayyon , Iris Kauffmann-Hefner
IPC分类号： C07D487/04 , C07D471/04 , A61K31/5025 , A61K31/437
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to substituted imidazo-pyridinones and imidazo-pyridazinones of general formula wherein R1 to R4 are defined as in claim 1, the tautomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibitory effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代的咪唑并 - 吡啶酮和咪唑并哒嗪酮，其中R 1至R 4定义如权利要求1，互变异构体，立体异构体， 其具有有价值的药理学特性的其混合物及其盐，特别是酶二肽基肽酶-IV（DPP-IV）的活性的抑制作用。
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8.发明申请Bicyclic imidazole derivatives, the preparation thereof and their use as pharmaceutical compositions 有权双环咪唑衍生物，其制备及其作为药物组合物的用途公开(公告)号：US20050143377A1
公开(公告)日：2005-06-30
申请号：US11018894
申请日：2004-12-21
申请人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Norbert Hauel , Mohammad Tadayyon , Leo Thomas
发明人： Frank Himmelsbach , Elke Langkopf , Matthias Eckhardt , Norbert Hauel , Mohammad Tadayyon , Leo Thomas
IPC分类号： A61K31/519 , A61K31/522 , A61K31/5377 , A61P3/00 , A61P19/00 , C07D473/02 , C07D473/04 , C07D473/06 , C07D487/04
CPC分类号： C07D473/04 , C07D473/06 , C07D487/04
摘要： The present invention relates to bicyclic imidazole compounds of general formula wherein R1 to R3 and A are defined as in claims 1 to 8, the tautomers, the enantiomers, the stereoisomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的双环咪唑化合物，其中R 1至R 3和A如权利要求1至8中所定义，互变异构体，对映异构体，立体异构体 ，其混合物及其盐具有有价值的药理学性质，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用。
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![8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical composition](/abs-image/US/2010/01/12/US07645763B2/abs.jpg.150x150.jpg)
9.发明授权8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical composition 有权8- [3-氨基 - 哌啶-1-基] - 黄嘌呤，它们的制备及其作为药物组合物的用途公开(公告)号：US07645763B2
公开(公告)日：2010-01-12
申请号：US11062518
申请日：2005-02-22
IPC分类号： C07D473/06 , C07D519/00 , A61K31/522 , A61P3/10 , A61P3/04
CPC分类号： C07D473/06
摘要： The present invention relates to substituted xanthines of general formula wherein R1 and R2 are defined as in the claims, the tautomers, the stereoisomers, the mixtures thereof, and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及通式的取代黄嘌呤：其中R 1和R 2如权利要求中所定义，其互变异构体，立体异构体，其混合物及其盐具有有价值的药理学性质，特别是对 酶二肽肽酶-IV（DPP-IV）。
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![2-amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions](/abs-image/US/2009/01/13/US07476671B2/abs.jpg.150x150.jpg)
10.发明授权2-amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions 有权2-氨基 - 咪唑并[4,5-d]哒嗪-4-酮，它们的制备及其作为药物组合物的用途公开(公告)号：US07476671B2
公开(公告)日：2009-01-13
申请号：US11609621
申请日：2006-12-12
申请人： Matthias Eckhardt , Frank Himmelsbach , Elke Langkopf , Norbert Hauel , Mohammad Tadayyon , Leo Thomas
发明人： Matthias Eckhardt , Frank Himmelsbach , Elke Langkopf , Norbert Hauel , Mohammad Tadayyon , Leo Thomas
IPC分类号： A61K31/5355 , A61K31/497 , A61K31/4439 , A61K31/4166 , C07D491/04 , C07D487/04 , C07D471/04 , A61P3/10
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention relates to 2-amino-imidazo[4,5-d]pyridazin-4-ones and 2-amino-imidazo[4,5-c]pyridin-4-ones of general formula wherein R1 to R4 and X are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV).
摘要翻译： 本发明涉及以下通式的2-氨基 - 咪唑并[4,5-d]哒嗪-4-酮和2-氨基 - 咪唑并[4,5-c]吡啶-4-酮，其中R1至R4和X为 如权利要求1至6中定义的互变异构体，对映异构体，非对映体，其混合物及其盐，其具有有价值的药理学性质，特别是对二肽基肽酶-IV（DPP-IV）的活性的抑制作用。
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