公开(公告)号：US06979471B1

公开(公告)日：2005-12-27

申请号：US09655710

申请日：2000-09-05

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq Ur Rahman

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq Ur Rahman

IPC分类号： A61K36/484 ,  A61K45/06 ,  A61K35/78

CPC分类号： A61K45/06 ,  A61K36/484 ,  A61K2300/00

摘要： The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

摘要翻译： 本发明涉及作为植物来源的糖苷“甘草甜素”的非生物碱化合物作为抗生素和其它药物（包括抗感染和抗癌剂）的活性和可获得性的高效生物增强剂的新用途。 本发明的分子有助于植物和动物细胞以及革兰氏阳性和革兰氏阴性菌在细胞膜上吸收/吸收抗生素和其他分子，因此可用作促进剂或生物增殖剂分子以增加感染性 的药物和营养药物。 本身没有抗微生物或细胞毒活性的化合物是减少药物用量以避免耐药性和抗感染和抗癌疗法中的其他副作用的安全候选物。

公开(公告)号：US20060057234A1

公开(公告)日：2006-03-16

申请号：US11269594

申请日：2005-11-09

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq-Ur Rahman

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq-Ur Rahman

IPC分类号： A61K36/484 ,  A61K31/496 ,  A61K31/4709

CPC分类号： A61K45/06 ,  A61K36/484 ,  A61K2300/00

摘要： The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

摘要翻译： 本发明涉及作为植物来源的糖苷“甘草甜素”的非生物碱化合物作为抗生素和其它药物（包括抗感染和抗癌剂）的活性和可获得性的高效生物增强剂的新用途。 本发明的分子有助于植物和动物细胞以及革兰氏阳性和革兰氏阴性菌在细胞膜上吸收/吸收抗生素和其他分子，因此可用作促进剂或生物增殖剂分子以增加感染性 的药物和营养药物。 本身没有抗微生物或细胞毒活性的化合物是减少药物用量以避免耐药性和抗感染和抗癌疗法中的其他副作用的安全候选物。

公开(公告)号：US07235262B2

公开(公告)日：2007-06-26

申请号：US10822790

申请日：2004-04-13

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06896907B2

公开(公告)日：2005-05-24

申请号：US10135763

申请日：2002-05-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  A61K35/24 ,  A61K35/23

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06410059B1

公开(公告)日：2002-06-25

申请号：US09726307

申请日：2000-12-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K3522

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： A pharmaceutical composition comprising an antibiotic and cow urine distillate in an amount effective to enhance antimicrobial effect of the antibiotic is disclosed. The antibiotic can be an antifungal agent. The antibiotic can be a quinolone or a fluoroquinolone. The antifungal agent can be azoles, clotrimazole, mystatin or amphotericin.

摘要翻译： 公开了一种药物组合物，其包含抗生素和牛尿液馏出物，其量有效提高抗生素的抗微生物作用。 抗生素可以是抗真菌剂。 抗生素可以是喹诺酮或氟喹诺酮类。 抗真菌剂可以是唑类，克霉唑，丝裂霉素或两性霉素。

公开(公告)号：US06660761B2

公开(公告)日：2003-12-09

申请号：US10066802

申请日：2002-02-06

申请人： Suman Preet Singh Khanuja ,  Puspalata Chatruvedi ,  Krishna Kumar Agarwal ,  Atique Ahmad ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Puspalata Chatruvedi ,  Krishna Kumar Agarwal ,  Atique Ahmad ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Sushil Kumar

IPC分类号： A61K314174

CPC分类号： A61K45/06 ,  A61K31/045 ,  A61K31/05 ,  A61K31/22 ,  A61K31/222 ,  A61K31/4174 ,  A61K31/4196 ,  A61K31/7048 ,  A61K2300/00

摘要： The present invention relates to a method of treatment of fungal infections consisting essentially of a synergistic combination of plant compounds that are useful for enhancing the activity of antifungal compounds. The plant compounds, menthol and menthyl acetate, when mixed at specific concentrations, enhance the antifungal activity of the commercially available fungicides.

摘要翻译： 本发明涉及一种治疗真菌感染的方法，其基本上由可用于增强抗真菌化合物活性的植物化合物的协同组合组成。 当以特定浓度混合时，植物化合物，薄荷醇和乙酸薄荷酯增强市售杀真菌剂的抗真菌活性。

公开(公告)号：US06455079B1

公开(公告)日：2002-09-24

申请号：US09923586

申请日：2001-08-07

申请人： Suman Preet Singh Khanuja ,  Sarita Satapathy ,  Subhash Chandra Singh ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Jai Shankar Arya ,  Arun Kumar Tripathy ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Sarita Satapathy ,  Subhash Chandra Singh ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Jai Shankar Arya ,  Arun Kumar Tripathy ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Sushil Kumar

IPC分类号： A61K3538

CPC分类号： A01N65/20 ,  A01N65/00 ,  A01N2300/00 ,  A01N63/00 ,  A01N63/02

摘要： The present invention provides a novel synergistic composition comprising extract obtained from the plant Albizzia lebbeck together with Bacillus thuringiensis &dgr;-endotoxin, useful in controlling lepidopteran insects, methods for the preparation of the composition and application of the insecticidal composition to standing crops.

公开(公告)号：US20090175842A1

公开(公告)日：2009-07-09

申请号：US12373096

申请日：2007-07-10

申请人： Chandrakant Laxminarayan Rathi ,  Jai Shankar Arya ,  Shilpa Prasanna Risbud

发明人： Chandrakant Laxminarayan Rathi ,  Jai Shankar Arya ,  Shilpa Prasanna Risbud

IPC分类号： A61K38/48

CPC分类号： A61K38/48 ,  A61K31/43 ,  A61K31/7048 ,  A61K38/4886 ,  A61K2300/00

摘要： A synergistic dietary antibacterial composition comprising the combination of proteolytic enzymes and one or more antibiotics effective against Helicobacter pylori, useful for the prevention or treatment of gastrointestinal disorders like peptic ulcer, gastric cancers and gastritis in the intestine caused by the Helicobacter pylori is disclosed in the present invention.

摘要翻译： 包含蛋白水解酶和一种或多种对幽门螺杆菌有效的抗生素的组合的协同膳食抗菌组合物可用于预防或治疗由幽门螺杆菌引起的胃肠胃疾病如消化性溃疡，胃肠炎和胃炎。 本发明。