公开(公告)号：US06979471B1

公开(公告)日：2005-12-27

申请号：US09655710

申请日：2000-09-05

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq Ur Rahman

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq Ur Rahman

IPC分类号： A61K36/484 ,  A61K45/06 ,  A61K35/78

CPC分类号： A61K45/06 ,  A61K36/484 ,  A61K2300/00

摘要： The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

摘要翻译： 本发明涉及作为植物来源的糖苷“甘草甜素”的非生物碱化合物作为抗生素和其它药物（包括抗感染和抗癌剂）的活性和可获得性的高效生物增强剂的新用途。 本发明的分子有助于植物和动物细胞以及革兰氏阳性和革兰氏阴性菌在细胞膜上吸收/吸收抗生素和其他分子，因此可用作促进剂或生物增殖剂分子以增加感染性 的药物和营养药物。 本身没有抗微生物或细胞毒活性的化合物是减少药物用量以避免耐药性和抗感染和抗癌疗法中的其他副作用的安全候选物。

公开(公告)号：US20060057234A1

公开(公告)日：2006-03-16

申请号：US11269594

申请日：2005-11-09

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq-Ur Rahman

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq-Ur Rahman

IPC分类号： A61K36/484 ,  A61K31/496 ,  A61K31/4709

CPC分类号： A61K45/06 ,  A61K36/484 ,  A61K2300/00

摘要： The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

摘要翻译： 本发明涉及作为植物来源的糖苷“甘草甜素”的非生物碱化合物作为抗生素和其它药物（包括抗感染和抗癌剂）的活性和可获得性的高效生物增强剂的新用途。 本发明的分子有助于植物和动物细胞以及革兰氏阳性和革兰氏阴性菌在细胞膜上吸收/吸收抗生素和其他分子，因此可用作促进剂或生物增殖剂分子以增加感染性 的药物和营养药物。 本身没有抗微生物或细胞毒活性的化合物是减少药物用量以避免耐药性和抗感染和抗癌疗法中的其他副作用的安全候选物。

公开(公告)号：US07235262B2

公开(公告)日：2007-06-26

申请号：US10822790

申请日：2004-04-13

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06896907B2

公开(公告)日：2005-05-24

申请号：US10135763

申请日：2002-05-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  A61K35/24 ,  A61K35/23

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06410059B1

公开(公告)日：2002-06-25

申请号：US09726307

申请日：2000-12-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K3522

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： A pharmaceutical composition comprising an antibiotic and cow urine distillate in an amount effective to enhance antimicrobial effect of the antibiotic is disclosed. The antibiotic can be an antifungal agent. The antibiotic can be a quinolone or a fluoroquinolone. The antifungal agent can be azoles, clotrimazole, mystatin or amphotericin.

摘要翻译： 公开了一种药物组合物，其包含抗生素和牛尿液馏出物，其量有效提高抗生素的抗微生物作用。 抗生素可以是抗真菌剂。 抗生素可以是喹诺酮或氟喹诺酮类。 抗真菌剂可以是唑类，克霉唑，丝裂霉素或两性霉素。

公开(公告)号：US06660761B2

公开(公告)日：2003-12-09

申请号：US10066802

申请日：2002-02-06

申请人： Suman Preet Singh Khanuja ,  Puspalata Chatruvedi ,  Krishna Kumar Agarwal ,  Atique Ahmad ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Puspalata Chatruvedi ,  Krishna Kumar Agarwal ,  Atique Ahmad ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Sushil Kumar

IPC分类号： A61K314174

CPC分类号： A61K45/06 ,  A61K31/045 ,  A61K31/05 ,  A61K31/22 ,  A61K31/222 ,  A61K31/4174 ,  A61K31/4196 ,  A61K31/7048 ,  A61K2300/00

摘要： The present invention relates to a method of treatment of fungal infections consisting essentially of a synergistic combination of plant compounds that are useful for enhancing the activity of antifungal compounds. The plant compounds, menthol and menthyl acetate, when mixed at specific concentrations, enhance the antifungal activity of the commercially available fungicides.

摘要翻译： 本发明涉及一种治疗真菌感染的方法，其基本上由可用于增强抗真菌化合物活性的植物化合物的协同组合组成。 当以特定浓度混合时，植物化合物，薄荷醇和乙酸薄荷酯增强市售杀真菌剂的抗真菌活性。

公开(公告)号：US06455079B1

公开(公告)日：2002-09-24

申请号：US09923586

申请日：2001-08-07

申请人： Suman Preet Singh Khanuja ,  Sarita Satapathy ,  Subhash Chandra Singh ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Jai Shankar Arya ,  Arun Kumar Tripathy ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Sarita Satapathy ,  Subhash Chandra Singh ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Jai Shankar Arya ,  Arun Kumar Tripathy ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Sushil Kumar

IPC分类号： A61K3538

CPC分类号： A01N65/20 ,  A01N65/00 ,  A01N2300/00 ,  A01N63/00 ,  A01N63/02

摘要： The present invention provides a novel synergistic composition comprising extract obtained from the plant Albizzia lebbeck together with Bacillus thuringiensis &dgr;-endotoxin, useful in controlling lepidopteran insects, methods for the preparation of the composition and application of the insecticidal composition to standing crops.

公开(公告)号：US06676974B2

公开(公告)日：2004-01-13

申请号：US10105794

申请日：2002-03-26

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Madan Mohan Gupta ,  Arvind Kumar Tripathy ,  Monika Singh ,  Janak Raj Bahl ,  Raj Kishori Lal ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Madan Mohan Gupta ,  Arvind Kumar Tripathy ,  Monika Singh ,  Janak Raj Bahl ,  Raj Kishori Lal ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

IPC分类号： A01N5906

CPC分类号： A61K36/899 ,  Y02A50/473

摘要： The present invention relates a hexane bioactive fraction and obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals; also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract

摘要翻译： 本发明涉及己烷生物活性级分，其获自在印度通常发现的名为Vetiveria zizanioides的芳香植物的根，用于抑制人和动物中耐药细菌感染的生长; 还涉及一种药物组合物，其包含生物活性提取物与用于抑制人和动物中耐药细菌感染生长的其它添加剂和分离所述生物活性提取物的方法

公开(公告)号：USPP13110P2

公开(公告)日：2002-10-22

申请号：US09538341

申请日：2000-03-29

申请人： Sushil Kumar ,  Janak Raj Bahl ,  Ravi Prakash Bansal ,  Shri Niwas Garg ,  Arif Ali Naqvi ,  Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Vikram Singh ,  Sweta Sinha

发明人： Sushil Kumar ,  Janak Raj Bahl ,  Ravi Prakash Bansal ,  Shri Niwas Garg ,  Arif Ali Naqvi ,  Suman Preet Singh Khanuja ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Vikram Singh ,  Sweta Sinha

IPC分类号： A01H500

CPC分类号： A01H5/02

摘要： A new and distinct mutant plant of Lippia alba called ‘Bhurakshak,’ characterized by novel aroma of the oil constituting 7.2% 1, 8 cineole, 42.3% linalool, 12.9% citral (b) and 14.2% citral (a) as a major terpenoids, and having a unique RAPD profile as shown in FIG. 1 of the drawings.

摘要翻译： 一种新的和不同的Lippia alba的突变植物称为“Bhurakshak”，其特征在于油的新颖香气构成主要萜类化合物的7.2％1,8Cineole，42.3％芳樟醇，12.9％柠檬醛（b）和14.2％柠檬醛（a） 并且具有如图1所示的唯一RAPD轮廓。

公开(公告)号：USPP12425P2

公开(公告)日：2002-02-26

申请号：US09537173

申请日：2000-03-29

申请人： Raghavendra Narayanrao Kulkarni ,  Nagawara Seshagirirao Ravindra ,  Srinivas Iyer Ramesh ,  Gopal Rao Mallavarapu ,  Suman Preet Singh Khanuja ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

发明人： Raghavendra Narayanrao Kulkarni ,  Nagawara Seshagirirao Ravindra ,  Srinivas Iyer Ramesh ,  Gopal Rao Mallavarapu ,  Suman Preet Singh Khanuja ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

IPC分类号： A01H500

CPC分类号： A01H6/42 ,  A01H5/02

摘要： The invention is related to the development of a new and distinct geranium plant called e ‘Narmada’ yeilding perfumery oil having higher content of rhodinol, total alcohol and high citronellol/geraniol ratio and lower content of undesirable isomenthone and 10-epi-&ggr;-eudesmol.

摘要翻译： 本发明涉及一种新的和独特的天竺葵植物的发展，称为具有较高含量的罗丹诺，总醇和高香茅醇/香叶醇比的“Narmada”造型香料油，并且含有较低含量的不希望的isomenthone和10-epi-gamma-eudesmol 。