公开(公告)号：US20060057234A1

公开(公告)日：2006-03-16

申请号：US11269594

申请日：2005-11-09

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq-Ur Rahman

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq-Ur Rahman

IPC分类号： A61K36/484 ,  A61K31/496 ,  A61K31/4709

CPC分类号： A61K45/06 ,  A61K36/484 ,  A61K2300/00

摘要： The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

摘要翻译： 本发明涉及作为植物来源的糖苷“甘草甜素”的非生物碱化合物作为抗生素和其它药物（包括抗感染和抗癌剂）的活性和可获得性的高效生物增强剂的新用途。 本发明的分子有助于植物和动物细胞以及革兰氏阳性和革兰氏阴性菌在细胞膜上吸收/吸收抗生素和其他分子，因此可用作促进剂或生物增殖剂分子以增加感染性 的药物和营养药物。 本身没有抗微生物或细胞毒活性的化合物是减少药物用量以避免耐药性和抗感染和抗癌疗法中的其他副作用的安全候选物。

公开(公告)号：US06896907B2

公开(公告)日：2005-05-24

申请号：US10135763

申请日：2002-05-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  A61K35/24 ,  A61K35/23

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06676974B2

公开(公告)日：2004-01-13

申请号：US10105794

申请日：2002-03-26

申请人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Madan Mohan Gupta ,  Arvind Kumar Tripathy ,  Monika Singh ,  Janak Raj Bahl ,  Raj Kishori Lal ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

发明人： Suman Preet Singh Khanuja ,  Suchi Srivastava ,  Tiruppadiripuliyur Ranganathan Santha Kumar ,  Madan Mohan Gupta ,  Arvind Kumar Tripathy ,  Monika Singh ,  Janak Raj Bahl ,  Raj Kishori Lal ,  Mahendra Pandurang Darokar ,  Ajit Kumar Shasany ,  Sushil Kumar

IPC分类号： A01N5906

CPC分类号： A61K36/899 ,  Y02A50/473

摘要： The present invention relates a hexane bioactive fraction and obtained from the roots of an aromatic plant named Vetiveria zizanioides commonly found in India for inhibiting the growth of drug resistant bacterial infections in humans and animals; also relates to a pharmaceutical composition comprising the bioactive extract with other additives for inhibiting the growth of drug resistant bacterial infections in humans and animals and a process for the isolation of said bioactive extract

摘要翻译： 本发明涉及己烷生物活性级分，其获自在印度通常发现的名为Vetiveria zizanioides的芳香植物的根，用于抑制人和动物中耐药细菌感染的生长; 还涉及一种药物组合物，其包含生物活性提取物与用于抑制人和动物中耐药细菌感染生长的其它添加剂和分离所述生物活性提取物的方法

公开(公告)号：US06410059B1

公开(公告)日：2002-06-25

申请号：US09726307

申请日：2000-12-01

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K3522

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： A pharmaceutical composition comprising an antibiotic and cow urine distillate in an amount effective to enhance antimicrobial effect of the antibiotic is disclosed. The antibiotic can be an antifungal agent. The antibiotic can be a quinolone or a fluoroquinolone. The antifungal agent can be azoles, clotrimazole, mystatin or amphotericin.

摘要翻译： 公开了一种药物组合物，其包含抗生素和牛尿液馏出物，其量有效提高抗生素的抗微生物作用。 抗生素可以是抗真菌剂。 抗生素可以是喹诺酮或氟喹诺酮类。 抗真菌剂可以是唑类，克霉唑，丝裂霉素或两性霉素。

公开(公告)号：US07235262B2

公开(公告)日：2007-06-26

申请号：US10822790

申请日：2004-04-13

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Ajit Kumar Shasany ,  Jai Shankar Arya ,  Mahendra Pandurang Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Chandra Gupta ,  Vivek Kumar Gupta ,  Madan Mohan Gupta ,  Ram Kishore Verma ,  Sweta Agarwal ,  Sunil Balkrishna Mansinghka ,  Suresh Haribhau Dawle

IPC分类号： A61K35/22

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06858588B2

公开(公告)日：2005-02-22

申请号：US10403814

申请日：2003-03-31

申请人： Suman Preet Singh Khanuja ,  Jai Shanker Arya ,  Ranganathan Santha Kumar Tiruppadiripuliyur ,  Dharmendra Saikia ,  Harpreet Kaur ,  Monika Singh ,  Subhash Chandra Gupta ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Santosh Kumar Srivastava ,  Madan Mohan Gupta ,  Subash Chandra Verma ,  Anirban Pal

发明人： Suman Preet Singh Khanuja ,  Jai Shanker Arya ,  Ranganathan Santha Kumar Tiruppadiripuliyur ,  Dharmendra Saikia ,  Harpreet Kaur ,  Monika Singh ,  Subhash Chandra Gupta ,  Ajit Kumar Shasany ,  Mahendra Pandurang Darokar ,  Santosh Kumar Srivastava ,  Madan Mohan Gupta ,  Subash Chandra Verma ,  Anirban Pal

IPC分类号： A61K31/704 ,  A61K45/06 ,  C07H15/06 ,  A61K31/70 ,  A61K31/7028 ,  C07C255/32 ,  C07H15/00

CPC分类号： C07H15/06 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to a novel nitrile glycoside of Formula I named NIAZIRIDIN and to analogues and derivatives thereof. The present invention also relates to a process for the isolation of a novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues by bioactivity-guided fractionation from the pods of Moringa oleifera. The present invention particularly relates to the bioenhancing activity of the novel nitrile glycoside of Formula I below named NIAZIRIDIN and its derivatives and analogues in enhancing bioactivity of commonly used antibiotics such as rifampicin, tetracycline and ampicillin against Gram (+) and (−) bacteria. The biomolecule also enhances the absorption of drugs, vitamins and nutrients through the gastro-intestinal membrane increasing their bio-availability. Therefore niaziridin can be used in combination therapy with drugs and nutrients resulting in reduced drug associated toxicity, reduced cost and duration of chemotherapy.

摘要翻译： 本发明涉及名为NIAZIRIDIN的式I的新型腈糖苷及其类似物及其衍生物。 本发明还涉及一种通过生物活性指导的分离来自pod the的荚果分离下述式I的新型腈糖苷的方法，其命名为NIAZIRIDIN及其衍生物和类似物。 本发明特别涉及下述命名为NIAZIRIDIN及其衍生物和类似物的式I的新型腈糖苷增强常用抗生素如利福平，四环素和氨苄青霉素对革兰氏阳性（+）和（ - ）细菌的生物活性的生物增强活性。 生物分子还通过胃肠膜增强药物，维生素和营养素的吸收，增加其生物利用度。 因此，尼日吉林可以与药物和营养物联合使用，导致药物相关毒性降低，降低成本和化疗持续时间。

公开(公告)号：US20050100610A1

公开(公告)日：2005-05-12

申请号：US10822790

申请日：2004-04-13

申请人： Suman Khanuja ,  Sushil Kumar ,  Ajit Shasany ,  Jai Arya ,  Mahendra Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Gupta ,  Vivek Gupta ,  Madan Gupta ,  Ram Verma ,  Sweta Agarwal ,  Sunil Mansinghka ,  Suresh Dawle

发明人： Suman Khanuja ,  Sushil Kumar ,  Ajit Shasany ,  Jai Arya ,  Mahendra Darokar ,  Monika Singh ,  Prachi Sinha ,  Soumya Awasthi ,  Subhash Gupta ,  Vivek Gupta ,  Madan Gupta ,  Ram Verma ,  Sweta Agarwal ,  Sunil Mansinghka ,  Suresh Dawle

IPC分类号： A61K35/22 ,  A61K45/06 ,  A61P31/00 ,  A61P35/00 ,  A61K33/40 ,  A61K31/4965 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/65

CPC分类号： A61K45/06 ,  A61K35/22 ,  A61K2300/00

摘要： The invention relates to a novel pharmaceutical composition comprising an effective amount of bio-active fraction from cow urine distillate as a bioavailability facilitator and pharmaceutically acceptable additives selected from anticancer compounds, antibiotics, drugs, therapeutic and nutraceutic agents, ions and similar molecules which are targeted to the living systems.

摘要翻译： 本发明涉及一种新型药物组合物，其包含有效量的来自牛尿馏分的生物活性级分作为生物利用度促进剂和选自抗癌化合物，抗生素，药物，治疗和营养药物，离子和类似分子的药学上可接受的添加剂 到生活系统。

公开(公告)号：US06979471B1

公开(公告)日：2005-12-27

申请号：US09655710

申请日：2000-09-05

申请人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq Ur Rahman

发明人： Suman Preet Singh Khanuja ,  Sushil Kumar ,  Jai Shankar Arya ,  Ajit Kumar Shasany ,  Monika Singh ,  Soumya Awasthi ,  Subhas Chandra Gupta ,  Mahendra Pandurang Darokar ,  Laiq Ur Rahman

IPC分类号： A61K36/484 ,  A61K45/06 ,  A61K35/78

CPC分类号： A61K45/06 ,  A61K36/484 ,  A61K2300/00

摘要： The invention relates to a new use of a non-alkaloid compound that is plant derived glycoside ‘glycyrrhizin’ as a highly potent bio-enhancer of activity and availability of antibiotics and other drugs including anti-infective and anticancer agents. The molecule of invention facilitates the absorption/uptake of antibiotics and other molecules across the cell membrane in plant and animal cells as well as Gram-positive and Gram-negative bacteria and therefore can be used as a drug facilitator or bioenhancer molecule to increase the affectivity of drugs and nutraceutical agents. The compound having no antimicrobial or cytotoxic activity of its own, is a safe candidate to reduce the drug dosage towards circumventing the problem of drug resistance and the other side effects in anti-infective and anti-cancer therapies.

摘要翻译： 本发明涉及作为植物来源的糖苷“甘草甜素”的非生物碱化合物作为抗生素和其它药物（包括抗感染和抗癌剂）的活性和可获得性的高效生物增强剂的新用途。 本发明的分子有助于植物和动物细胞以及革兰氏阳性和革兰氏阴性菌在细胞膜上吸收/吸收抗生素和其他分子，因此可用作促进剂或生物增殖剂分子以增加感染性 的药物和营养药物。 本身没有抗微生物或细胞毒活性的化合物是减少药物用量以避免耐药性和抗感染和抗癌疗法中的其他副作用的安全候选物。