公开(公告)号：US20040138496A1

公开(公告)日：2004-07-15

申请号：US10727398

申请日：2003-12-04

Applicant: Sumika Fine Chemicals Co., Ltd.

Inventor： Masahide Tanaka ,  Kozo Matsui ,  Tadashi Katsura ,  Mitsuhiro Iwasaki ,  Hiroshi Maeda ,  Nobushige Itaya

IPC: C07C051/347

CPC classification number: C07C45/74 ,  C07B2200/07 ,  C07C45/62 ,  C07C45/73 ,  C07C49/213 ,  C07C51/43 ,  C07C51/487 ,  C07C69/732 ,  C07C211/29 ,  C07C217/58 ,  C07C49/217 ,  C07C59/48

Abstract: The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) 1 wherein R2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.

Abstract translation: 本发明涉及（R）-3-羟基-3-（2-苯基乙基）己酸的制备方法，该方法包括用光学活性胺将外消旋3-羟基-3-（2-苯基乙基）己酸旋光拆分 的式（VIII）其中R 2是3,4-二甲氧基苯基或2-氯苯基。 根据本发明，可以以高光学纯度和较高的总产率有效地制备可用作药剂原料的（R）-3-羟基-3-（2-苯基乙基）己酸。

公开(公告)号：US20030176507A1

公开(公告)日：2003-09-18

申请号：US10320325

申请日：2002-12-16

Applicant: Sumika Fine Chemicals Co., Ltd.

Inventor： Masahide Tanaka ,  Kozo Matsui ,  Tadashi Katsura ,  Mitsuhiro Iwasaki ,  Hiroshi Maeda ,  Nobushige Itaya

IPC: A61K031/192 ,  C07C059/64

CPC classification number: C07C45/74 ,  C07B2200/07 ,  C07C45/62 ,  C07C45/73 ,  C07C49/213 ,  C07C51/43 ,  C07C51/487 ,  C07C69/732 ,  C07C211/29 ,  C07C217/58 ,  C07C49/217 ,  C07C59/48

Abstract: The present invention relates to a production method of (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid which comprises optical resolution of racemic 3-hydroxy-3-(2-phenylethyl)hexanoic acid with an optically active amine of the formula (VIII) 1 wherein R2 is 3,4-dimethoxyphenyl or 2-chlorophenyl. According to the present invention, (R)-3-hydroxy-3-(2-phenylethyl)hexanoic acid useful as a starting material of a pharmaceutical agent can be efficiently produced with a high optical purity and a relatively high total yield.

Abstract translation: 本发明涉及（R）-3-羟基-3-（2-苯基乙基）己酸的制备方法，该方法包括用光学活性胺将外消旋3-羟基-3-（2-苯基乙基）己酸旋光拆分 其中R 2是3,4-二甲氧基苯基或2-氯苯基。 根据本发明，可以以高光学纯度和较高的总产率有效地制备可用作药剂原料的（R）-3-羟基-3-（2-苯基乙基）己酸。