公开(公告)号：US20060193919A1

公开(公告)日：2006-08-31

申请号：US11212645

申请日：2005-08-29

申请人： Sumio Iijima ,  Masako Yudasaka ,  Kumiko Ajima ,  Tatsuya Murakami ,  Kiyotaka Shiba

发明人： Sumio Iijima ,  Masako Yudasaka ,  Kumiko Ajima ,  Tatsuya Murakami ,  Kiyotaka Shiba

IPC分类号： A61K38/14 ,  A61K33/24 ,  A61K31/573 ,  A61K9/14

CPC分类号： A61K9/167 ,  A61K9/1617 ,  A61K31/573 ,  A61K33/24 ,  Y10S977/734 ,  Y10S977/744 ,  Y10S977/906

摘要： The present invention provides a carbon nanohorn complex that is excellent in characteristics of adsorption or inclusion of drugs and release, in particular, a sustained release of drugs as a novel drug carrier in drug delivery systems, as well as a process for producing the complex. The complex of drug and carbon nanohorns comprises a steroidal or metal-containing drug being adsorbed onto the oxidized carbon nanohorns, or included in pores opened thereof.

公开(公告)号：US07537786B2

公开(公告)日：2009-05-26

申请号：US11212645

申请日：2005-08-29

申请人： Sumio Iijima ,  Masako Yudasaka ,  Kumiko Ajima ,  Tatsuya Murakami ,  Kiyotaka Shiba

发明人： Sumio Iijima ,  Masako Yudasaka ,  Kumiko Ajima ,  Tatsuya Murakami ,  Kiyotaka Shiba

IPC分类号： A61K9/14 ,  A61K33/24 ,  A61K38/16

CPC分类号： A61K9/167 ,  A61K9/1617 ,  A61K31/573 ,  A61K33/24 ,  Y10S977/734 ,  Y10S977/744 ,  Y10S977/906

摘要： The present invention provides a carbon nanohorn complex that is excellent in characteristics of adsorption or inclusion of drugs and release, in particular, a sustained release of drugs as a novel drug carrier in drug delivery systems, as well as a process for producing the complex. The complex of drug and carbon nanohorns comprises a steroidal or metal-containing drug being adsorbed onto the oxidized carbon nanohorns, or included in pores opened thereof.

摘要翻译： 本发明提供一种碳纳米角复合物，其特征在于吸附或包裹药物，特别是药物递送系统中作为新型药物载体的药物的持续释放以及生产该复合物的方法。 药物和碳纳米角的复合物包含吸附在氧化的碳纳米角上的甾体或含金属的药物，或包含在其中打开的孔中。

公开(公告)号：US20050271807A1

公开(公告)日：2005-12-08

申请号：US10895955

申请日：2004-07-22

申请人： Sumio Iljima ,  Kumiko Ajima ,  Masako Yudasaka

发明人： Sumio Iljima ,  Kumiko Ajima ,  Masako Yudasaka

IPC分类号： B82B3/00 ,  B01D15/00 ,  B01J20/20 ,  B05D7/00 ,  C01B31/02

CPC分类号： B82Y40/00 ,  B01D15/00 ,  B01J20/20 ,  B01J20/205 ,  B82Y30/00 ,  C01B32/152 ,  C01B32/178 ,  C01B2202/02

摘要： The objects of this patent application are to provide a new nano-extraction method for guest molecules to be incorporated into single-wall carbon nanotube (SWNT) comprising: putting guest molecules in solvent, wherein the guest molecules have a poor affinity to the solvent and a strong affinity to single-wall carbon nanotube (SWNT) and the attractive force between the guest molecules and SWNT is greater than that between the guest molecules and solvent molecules and that between the solvent molecules and SWNT, ultrasonicating the solution including the solvent and quest molecules, adding single-wall carbon nanotube (SWNT) or single-wall carbon nanotubes (SWNTs) with opened tips and wall-holes in the solution, and leaving the SWNT-guest molecules-solvent mixture until becoming stable with the guest molecules incorporated into SWNT at room temperature, and a nano-condensation method for guest molecules to be incorporated into single-wall carbon nanotube (SWNT) comprising: dropping saturated solution including solvent and guest molecules having a strong affinity to the solvent and a strong affinity to single-wall carbon nanotube (SWNT) onto SWNT or SWNTs placed on a grid disk laid on filtration paper for sucking up the excess solution as quickly as possible.

摘要翻译： 本专利申请的目的是为客体分子提供纳入单壁碳纳米管（SWNT）的新型纳米提取方法，包括：将客体分子置于溶剂中，其中客体分子对溶剂的亲和力差， 对单壁碳纳米管（SWNT）的强亲和力和客体分子与SWNT之间的吸引力大于客体分子和溶剂分子之间的吸引力，以及溶剂分子与SWNT之间的吸引力，超声波包含溶剂和任务的溶液 分子，在溶液中加入具有开口端和壁孔的单壁碳纳米管（SWNT）或单壁碳纳米管（SWNT），并留下SWNT-客体分子 - 溶剂混合物，直到使客体分子结合成稳定 SWNT在室温下的纳米缩合方法，以及将纳入到单壁碳纳米管（SWNT）中的客体分子的纳米缩合方法，包括：降低satura 包括对溶剂具有强亲和力的溶剂和客体分子，以及对放置在过滤纸上的网格盘上的单壁碳纳米管（SWNT）的强亲合力，以便尽可能快吸吮多余的溶液 。