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1.发明授权公开(公告)号：US07537786B2
公开(公告)日：2009-05-26
申请号：US11212645
申请日：2005-08-29
CPC分类号： A61K9/167 , A61K9/1617 , A61K31/573 , A61K33/24 , Y10S977/734 , Y10S977/744 , Y10S977/906
摘要： The present invention provides a carbon nanohorn complex that is excellent in characteristics of adsorption or inclusion of drugs and release, in particular, a sustained release of drugs as a novel drug carrier in drug delivery systems, as well as a process for producing the complex. The complex of drug and carbon nanohorns comprises a steroidal or metal-containing drug being adsorbed onto the oxidized carbon nanohorns, or included in pores opened thereof.
摘要翻译： 本发明提供一种碳纳米角复合物，其特征在于吸附或包裹药物，特别是药物递送系统中作为新型药物载体的药物的持续释放以及生产该复合物的方法。 药物和碳纳米角的复合物包含吸附在氧化的碳纳米角上的甾体或含金属的药物，或包含在其中打开的孔中。
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公开(公告)号：US20060193919A1
公开(公告)日：2006-08-31
申请号：US11212645
申请日：2005-08-29
IPC分类号： A61K38/14 , A61K33/24 , A61K31/573 , A61K9/14
CPC分类号： A61K9/167 , A61K9/1617 , A61K31/573 , A61K33/24 , Y10S977/734 , Y10S977/744 , Y10S977/906
摘要： The present invention provides a carbon nanohorn complex that is excellent in characteristics of adsorption or inclusion of drugs and release, in particular, a sustained release of drugs as a novel drug carrier in drug delivery systems, as well as a process for producing the complex. The complex of drug and carbon nanohorns comprises a steroidal or metal-containing drug being adsorbed onto the oxidized carbon nanohorns, or included in pores opened thereof.
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公开(公告)号：US20050277160A1
公开(公告)日：2005-12-15
申请号：US11098763
申请日：2005-04-04
申请人： Kiyotaka Shiba , Daisuke Kase , Sumio Iijima
发明人： Kiyotaka Shiba , Daisuke Kase , Sumio Iijima
IPC分类号： C12N15/09 , C07K7/06 , C07K7/08 , C07K17/14 , C07K19/00 , C12N7/00 , C12Q1/70 , C12Q1/68 , A61K38/10 , G01N33/53
摘要： It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as carbon nanohoms or carbon nanotubes, an artificial protein or a chimeric molecule comprising the above-described peptide bonded to a functional peptide, a protein, a labeling, etc., and a complex of the above-described peptide molecule, artificial protein or chimeric molecule with a nanographite structure. By panning peptide-presenting phages bonded to nanographite structures, a nanographite structure-binding peptide capable of specifically recognizing nanographite structures such as carbon nanohoms or carbon nanotubes is obtained.
摘要翻译： 本发明旨在提供一种识别纳米尺度结构的肽或噬菌体，从而能够有效地识别，结合，分离和取代纳米石墨结构如碳纳米管或碳纳米管，人造蛋白或包含上述肽的嵌合分子 功能性肽，蛋白质，标记等，以及上述肽分子，人造蛋白质或嵌合分子与纳米石墨结构的复合物。 通过淘选结合纳米尺度结构的肽呈递噬菌体，可以获得能够特异性识别纳米尺度结构如纳米碳纳米管或碳纳米管的纳米结构结合肽。
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公开(公告)号：US07462462B2
公开(公告)日：2008-12-09
申请号：US11098763
申请日：2005-04-04
申请人： Kiyotaka Shiba , Daisuke Kase , Sumio Iijima
发明人： Kiyotaka Shiba , Daisuke Kase , Sumio Iijima
摘要： It is intended to provide a peptide or a phage recognizing nanographite structures and thus enabling efficient recognition, binding, separation and alignment of nanographite structures such as carbon nanohorns or carbon nanotubes, an artificial protein or a chimeric molecule comprising the above-described peptide bonded to a functional peptide, a protein, a labeling, etc., and a complex of the above-described peptide molecule, artificial protein or chimeric molecule with a nanographite structure. By panning peptide-presenting phages bonded to nanographite structures, a nanographite structure-binding peptide capable of specifically recognizing nanographite structures such as carbon nanohorns or carbon nanotubes is obtained.
摘要翻译： 本发明旨在提供一种识别纳米尺度结构的肽或噬菌体，从而能够有效地识别，结合，分离和取向纳米尺度结构例如碳纳米管或碳纳米管，人造蛋白或包含上述肽的嵌合分子 功能性肽，蛋白质，标记等，以及上述肽分子，人造蛋白质或嵌合分子与纳米石墨结构的复合物。 通过筛选结合纳米尺度结构的肽呈递噬菌体，可以获得能够特异性识别纳米尺度结构如纳米碳纳米管或碳纳米管的纳米结构结合肽。
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5.发明申请公开(公告)号：US20060257931A1
公开(公告)日：2006-11-16
申请号：US11354864
申请日：2006-02-16
申请人： Ichiro Yamashita , Kiyotaka Shiba
发明人： Ichiro Yamashita , Kiyotaka Shiba
CPC分类号： C07K14/47 , C07K2319/00 , G01N33/553
摘要： A method for selectively arranging ferritin modified with a peptide, which specifically binds to titanium, to titanium formed on a substrate surface is provided. The method for arranging ferritin of the present invention is characterized in that ferritin is selectively bound on titanium on a substrate by modifying the N-terminal part of ferritin with a peptide which specifically binds to titanium. Also, the method for arranging ferritin of the present invention is characterized in that selectivity for titanium can be markedly improved by adding a nonionic surface activating agent.
摘要翻译： 提供了一种选择性地将由钛特异性结合的肽修饰的铁蛋白修饰成在基底表面上形成的钛的方法。 本发明的铁蛋白的配置方法的特征在于，通过用特异性结合钛的肽修饰铁蛋白的N末端部分，将铁蛋白选择性地结合在底物上的钛上。 此外，本发明的铁蛋白的配置方法的特征在于，通过添加非离子表面活性剂，能够显着提高钛的选择性。
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公开(公告)号：US6063595A
公开(公告)日：2000-05-16
申请号：US871809
申请日：1997-06-09
申请人： Kiyotaka Shiba
发明人： Kiyotaka Shiba
摘要： A method of forming a macromolecular microgene polymer comprises allowing DNA polymerase to act on oligonucleotides A and B complementary at least partially to each other to effect polymerase chain reaction. According to the present invention, there can be obtained a polymer consisting of a repeating microgene, which is efficiently and simply formed.
摘要翻译： 形成大分子微基因聚合物的方法包括允许DNA聚合酶对彼此至少部分互补的寡核苷酸A和B起作用以进行聚合酶链式反应。 根据本发明，可以获得由有效且简单地形成的重复微根组成的聚合物。
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公开(公告)号：US07498403B2
公开(公告)日：2009-03-03
申请号：US10566535
申请日：2004-07-30
申请人： Kiyotaka Shiba , Kenichi Sano
发明人： Kiyotaka Shiba , Kenichi Sano
CPC分类号： C07K7/06 , C07K7/08 , G01N33/5308 , G01N33/553 , G01N33/56983 , G01N33/84 , G01N2500/00
摘要： The present invention provides a peptide sequence, a phage, an artificial protein or a chimeric molecule having a binding ability to titanium, silver, silicon, necessary to confer higher capacity of titanium, silver, silicon material with the use of soft matters, or to provide a complex of a peptide, a phage, an artificial protein or a chimeric molecule, and titanium, having the peptide sequence and functional peptide sequence. By bringing into contact a population of phage wherein said phage of said population collectively express a library of different peptide sequence, recovering titanium bound to phage particles via peptide sequence by centrifugation, proliferating the obtained phage particles in bacteria, and repeating panning operation and concentrating titanium binding phage clones. Among the phage clones, peptide RKLPDAPGMHTW (SEQ ID NO: 3) and the like is identified. As for a peptide having a binding ability to titanium, silver, silicon, RKLPDA (SEQ ID NO: 1) or RALPDA (SEQ ID NO: 2) can be exemplified.
摘要翻译： 本发明提供了具有与钛，银，硅的结合能力的肽序列，噬菌体，人造蛋白或嵌合分子，其必须赋予使用软质的钛，银，硅材料更高的容量，或 提供具有肽序列和功能性肽序列的肽，噬菌体，人造蛋白或嵌合分子的复合物和钛。 通过与所述群体的噬菌体接触，其中所述群体的所述噬菌体共同表达不同肽序列的文库，通过离心回收通过肽序列与噬菌体颗粒结合的钛，使获得的噬菌体颗粒在细菌中增殖，并重复平移操作并浓缩钛 结合噬菌体克隆。 在噬菌体克隆中，鉴定了肽RKLPDAPGMHTW（SEQ ID NO：3）等。 对于具有钛，银，硅，RKLPDA（SEQ ID NO：1）或RALPDA（SEQ ID NO：2）的结合能力的肽。
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公开(公告)号：US07243031B2
公开(公告)日：2007-07-10
申请号：US10746036
申请日：2003-12-29
申请人： Yoko Satou , Masato Kitajima , Kiyotaka Shiba
发明人： Yoko Satou , Masato Kitajima , Kiyotaka Shiba
CPC分类号： C12N15/1034 , C07K7/08
摘要： A multifunctional base sequence method largely shortens the calculation time and reduces the volume of memory consumption of a processor by carrying out calculation with the advance exclusion of base sequences in which translation termination codons emerge in the second and third reading frames, which are to be excluded in the end. Focusing on the fact that a dipeptide sequence already contains information about the translation products of the second and third reading frames, proteins are analyzed and calculated as duplicated connective products of dipeptide sequences, and are not analyzed as connective products of 20 kinds of amino acids.
摘要翻译： 多功能碱基序列方法大大缩短了计算时间，并通过执行计算来减少处理器的存储器消耗量，其中基本序列的预先排除，其中翻译终止密码在第二和第三读取帧中出现，这将被排除 到底。 针对二肽序列已经包含关于第二和第三阅读框的翻译产物的信息的事实，蛋白质被分析和计算为二肽序列的重复连接产物，并且不作为20种氨基酸的连接产物进行分析。
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公开(公告)号：US20070112174A1
公开(公告)日：2007-05-17
申请号：US10566535
申请日：2004-07-30
申请人： Kiyotaka Shiba , Kenichi Sano
发明人： Kiyotaka Shiba , Kenichi Sano
CPC分类号： C07K7/06 , C07K7/08 , G01N33/5308 , G01N33/553 , G01N33/56983 , G01N33/84 , G01N2500/00
摘要： The present invention provides a peptide sequence, a phage, an artificial protein or a chimeric molecule having a binding ability to titanium, silver, silicon, necessary to confer higher capacity of titanium, silver, silicon material with the use of soft matters, or to provide a complex of a peptide, a phage, an artificial protein or a chimeric molecule, and titanium, having the peptide sequence and functional peptide sequence. By bringing into contact a population of phage wherein said phage of said population collectively express a library of different peptide sequence, recovering titanium bound to phage particles via peptide sequence by centrifugation, proliferating the obtained phage particles in bacteria, and repeating panning operation and concentrating titanium binding phage clones. Among the phage clones, peptide RKLPDAPGMHTW and the like is identified. As for a peptide having a binding ability to titanium, silver, silicon, RKLPDA or RALPDA can be exemplified.
摘要翻译： 本发明提供了具有与钛，银，硅的结合能力的肽序列，噬菌体，人造蛋白或嵌合分子，其必须赋予使用软质的钛，银，硅材料更高的容量，或 提供具有肽序列和功能性肽序列的肽，噬菌体，人造蛋白或嵌合分子的复合物和钛。 通过与所述群体的噬菌体接触，其中所述群体的所述噬菌体共同表达不同肽序列的文库，通过离心回收通过肽序列与噬菌体颗粒结合的钛，使获得的噬菌体颗粒在细菌中增殖，并重复平移操作并浓缩钛 结合噬菌体克隆。 在噬菌体克隆中，鉴定了肽RKLPDAPGMHTW等。 对于具有与钛的结合能力的肽，可以例举银，硅，RKLPDA或RALPDA。
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10.发明授权Human isoleucyl-tRNA synthetase proteins, nucleic acids and tester strains comprising same 失效人类异亮氨酰-tRNA合成酶蛋白，包含其的核酸和测试菌株
公开(公告)号：US5759833A
公开(公告)日：1998-06-02
申请号：US468557
申请日：1995-06-06
CPC分类号： C12N9/93
摘要： Isolated, recombinant nucleic acids which encode an isoleucyl-tRNA synthetase (IleRS) of human origin have been used to make expression constructs and transformed host cells for the production of a recombinant human IleRS. A recombinant enzyme has been purified, and is active in the specific aminoacylation of tRNA by isoleucine. Isolated, recombinant enzyme, and antibodies made specifically thereto, can be useful in assays to diagnose and monitor the autoimmune disease known as "antisynthetase syndrome." The essential isoleucyl-tRNA synthetases of microbes pathogenic in humans can be the targets of inhibitory agents having antimicrobial activity. A human isoleucyl-tRNA synthetase, isolated and purified, can be used to assess the toxic effect in humans of such an inhibitory agent in various biochemical activity assays. This human enzyme can also be expressed in "tester strains," whose cells rely upon the function of the human isoleucyl-tRNA synthetase for tRNA.sup.Ile charging. Such tester strains can be used to test for any toxic effects of an antimicrobial agent that specifically interacts with a heterologous human IleRS gene or gene product.
摘要翻译： 已经使用编码人来源的异亮氨酰-tRNA合成酶（IleRS）的分离的重组核酸来制备表达构建体和转化的宿主细胞以产生重组人IleRS。 重组酶已被纯化，并且在异亮氨酸的特异性氨基酰化tRNA中具有活性。 分离的重组酶和特异性制备的抗体可用于诊断和监测被称为“抗体合成酶综合征”的自身免疫疾病的测定中。 人类致病微生物的基本的异亮氨酰-tRNA合成酶可以是具有抗微生物活性的抑制剂的靶标。 分离和纯化的人类异亮氨酰-tRNA合成酶可用于评估在各种生物化学活性测定中人类对这种抑制剂的毒性作用。 这种人类酶也可以在“测试菌株”中表达，其细胞依赖于人类异亮氨酰-tRNA合成酶的功能用于tRNA充电。 这样的测试菌株可用于测试与异源人IleRS基因或基因产物特异性相互作用的抗微生物剂的任何毒性作用。
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