公开(公告)号：US10377749B2

公开(公告)日：2019-08-13

申请号：US15751014

申请日：2016-08-09

申请人： Sumitomo Dainippon Pharma Co., Ltd.

发明人： Akihito Nonoyama ,  Kazuki Hashimoto

IPC分类号： C07D417/14 ,  A61K31/427 ,  A61K31/4439

摘要： The present invention addresses the problem of providing a purification method for a 5-(thiazol-4-yl)indolin-2-one derivative that is useful as a medication. The present invention provides a purification method for a compound represented by formula (1) (in the formula, each n is independently 2, 3, 4, 5, or 6, R1 and R2 are identical or different and each independently represent a C1-6 alkyl group, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 each represent a hydrogen atom, a C1-6 alkyl group, an aryl group, or a heteroaryl group), or a geometric isomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof. The purification method includes a purification step performed using a solid-phase support adsorbent in the presence of a purification solvent.

公开(公告)号：US10329267B2

公开(公告)日：2019-06-25

申请号：US15744366

申请日：2016-07-15

申请人： Sumitomo Dainippon Pharma Co., Ltd.

发明人： Toshikazu Yagi ,  Satoshi Suzuki ,  Hiroto Tatamidani ,  Kazuki Hashimoto

IPC分类号： C07D303/38 ,  C07D307/92 ,  C07C49/227 ,  B01J21/08 ,  B01J29/06 ,  C07B63/02 ,  C07B63/04 ,  C07C49/215 ,  A61K31/343 ,  C07C45/65 ,  C07C31/04 ,  C07C31/08 ,  C07C43/20

摘要： The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.