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    NOVEL COCRYSTALLIZATION
    3.
    发明申请
    NOVEL COCRYSTALLIZATION 失效
    新的结构化

    公开(公告)号：US20110257430A1

    公开(公告)日：2011-10-20

    申请号：US13170701

    申请日：2011-06-28

    申请人： Scott L. CHILDS

    发明人： Scott L. CHILDS

    IPC分类号： C07C229/34 ,  C07C49/215

    CPC分类号： C07C49/255 ,  C07C217/20

    摘要： The present disclosure relates to novel cocrystals and novel methods for cocrystallization. In particular, the disclosure includes cocrystals comprising a salt of an active agent, such as a chloride salt of an active pharmaceutical ingredient. The present disclosure also relates to methods of preparing cocrystals and methods for screening for solid state phases.

    摘要翻译： 本公开涉及新型共晶和新型共结晶方法。 具体地，本公开包括包含活性剂的盐如活性药物成分的氯化物盐的共晶体。 本公开还涉及制备共晶体的方法和用于筛选固态相的方法。

    Compositions for use as a signal generation component and methods of using same
    5.
    发明授权
    Compositions for use as a signal generation component and methods of using same 有权
    用作信号发生组件的组合物及其使用方法

    公开(公告)号：US07691647B2

    公开(公告)日：2010-04-06

    申请号：US11499519

    申请日：2006-08-04

    申请人： Alan R. Craig ,  Zhu Teng ,  Richard C. Wright ,  Chengrong Wang

    发明人： Alan R. Craig ,  Zhu Teng ,  Richard C. Wright ,  Chengrong Wang

    IPC分类号： G01N33/553 ,  G01N33/548 ,  G01N33/543 ,  G01N33/546 ,  G01N33/24 ,  C07C49/15 ,  C07C49/215

    CPC分类号： G01N33/586 ,  G01N33/582 ,  G01N2458/40 ,  Y10S435/968

    摘要： Compositions suitable for use as signal generation components of an immunoassay, and methods for their use. According to one aspect of the invention, the composition includes a carrier having a coating of an aminodextran and a metal chelate incorporated therein. The metal chelate is present in the amount of at least 0.065 μMole per gram of carrier, and the aminodextran coating density averaging at least about 45 μg per milligram of carrier. In another aspect of the invention, carrier is dyed with a complex having the formula: M(L1)x(L2)y, wherein M is a metal selected from the group consisting of europium, terbium, dysprosium, samarium, osmium and ruthenium; L1 is a ligand selected from the group consisting of DPP, TOPO, TPPO; L2 comprises a ligand having the formula wherein R is one or more substituents, each substituent comprising an electron donating group; n=2-10; x=1-2; and y=2-4.

    摘要翻译： 适用于免疫测定的信号产生组分的组合物及其使用方法。 根据本发明的一个方面，组合物包括具有氨基葡聚糖和金属螯合物的涂层的载体。 金属螯合物以每克载体至少0.065mMole的量存在，并且氨基葡聚糖涂层密度平均至少约45μg/毫克载体。 在本发明的另一方面，载体用具有下式的复合物染色：M（L1）x（L2）y，其中M是选自铕，铽，镝，钐，锇和钌的金属; L1是选自DPP，TOPO，TPPO; L2包含具有下式的配体：其中R是一个或多个取代基，每个取代基包括给电子基团; n = 2-10; x = 1-2; y = 2-4。