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1.发明申请INOSITOL AND TREHALOSE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS FOR TREATING NEURODEGENERATIVE DISEASES COMPRISING THE SAME 审中-公开用于治疗包含其中的神经变性疾病的异维酮和三氢叶酸衍生物和药物组合物公开(公告)号：US20110224423A1
公开(公告)日：2011-09-15
申请号：US13003414
申请日：2009-03-23
申请人： Sung-Kee Chung , Woo Sirl Lee , Boram Kim , Jungkyun Im , Subhash C. Ghosh
发明人： Sung-Kee Chung , Woo Sirl Lee , Boram Kim , Jungkyun Im , Subhash C. Ghosh
IPC分类号： C07H15/02 , C07C279/12
摘要： The invented inositol and trehalose derivatives, prepared by introducing multiple units of the guanidine group to the backbone molecules, show excellent blood-brain barrier permeability, and accordingly, it can be easily transported to the brain tissues and utilized for the treatment of neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.
摘要翻译： 通过将多个单元的胍基引入骨架分子而制备的本发明的肌醇和海藻糖衍生物显示出优异的血脑屏障通透性，因此可以容易地转运至脑组织并用于治疗神经变性疾病 作为阿尔茨海默病和亨廷顿舞蹈病。
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2.发明授权Molecular transporters based on sugar and its analogues and processes for the preparation thereof 有权基于糖及其类似物的分子转运蛋白及其制备方法公开(公告)号：US07846975B2
公开(公告)日：2010-12-07
申请号：US11815339
申请日：2005-06-29
摘要： The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
摘要翻译： 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于递送各种生物活性分子。
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3.发明授权Molecular transporters based on sugar and its analogues and processes for the preparation thereof 有权基于糖及其类似物的分子转运蛋白及其制备方法公开(公告)号：US08058413B2
公开(公告)日：2011-11-15
申请号：US12860538
申请日：2010-08-20
摘要： The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
摘要翻译： 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于递送各种生物活性分子。
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4.发明申请MOLECULAR TRANSPORTERS BASED ON SUGAR AND ITS ANALOGUES AND PROCESSES FOR THE PREPARATION THEREOF 有权基于糖的分子运输机及其制备方法及其制备方法公开(公告)号：US20100330608A1
公开(公告)日：2010-12-30
申请号：US12860439
申请日：2010-08-20
IPC分类号： C12Q1/02 , C07C229/12 , C07H19/213 , C12N5/00
摘要： The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
摘要翻译： 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于递送各种生物活性分子。
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5.发明申请公开(公告)号：US20080249296A1
公开(公告)日：2008-10-09
申请号：US11815339
申请日：2005-06-29
IPC分类号： C07H15/04
摘要： The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
摘要翻译： 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于递送各种生物活性分子。
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6.发明授权公开(公告)号：US08048996B2
公开(公告)日：2011-11-01
申请号：US12860439
申请日：2010-08-20
摘要： The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
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7.发明授权Molecular transporters based on alditol or inositol and processes for the preparation thereof 有权基于糖醇或肌醇的分子转运蛋白及其制备方法公开(公告)号：US07973084B2
公开(公告)日：2011-07-05
申请号：US11844455
申请日：2007-08-24
CPC分类号： C07H15/252 , C07D305/14
摘要： The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, it can be effectively used in delivering various biologically active molecules, such as doxorubicin and paclitaxel to target cells.
摘要翻译： 本发明的分子转运体化合物通过诸如质膜，核膜和血脑屏障的生物膜显示出显着高的渗透性，因此可以有效地用于向目标细胞递送各种生物活性分子，如多柔比星和紫杉醇。
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8.发明申请公开(公告)号：US20100330671A1
公开(公告)日：2010-12-30
申请号：US12860538
申请日：2010-08-20
摘要： The inventive molecular transporter compound shows significantly high permeability through a biological membrane such as a plasma membrane, nuclear membrane and blood-brain barrier, and accordingly, can be effectively used in delivering various biologically active molecules.
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