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    Process for the production of vasicine
    1.
    发明授权
    Process for the production of vasicine 失效
    生产vasicine的过程

    公开(公告)号：US06676976B2

    公开(公告)日：2004-01-13

    申请号：US10104765

    申请日：2002-03-21

    申请人： Sunil Kumar Chattopadhyay ,  Guru Das Bagchi ,  Prem Dutt Dwivedi ,  Sachin Srivastava

    发明人： Sunil Kumar Chattopadhyay ,  Guru Das Bagchi ,  Prem Dutt Dwivedi ,  Sachin Srivastava

    IPC分类号： A61K3578

    CPC分类号： C07D487/04

    摘要： The present invention relates to an improved process for the production of vasicine of formula (1) from the Adhatoda vasica, said process comprising the steps of: extracting the dried and pulverized leaves with an alcoholic extract at an ambient temperature, concentrating the alcoholic extract to obtain a concentrated extract, treating and stirring extract with an aqueous organic acid for 2-24 hours, extracting the acid solution of with an organic solvent, separating the organic layer and aqueous acidic layer, basifying the aqueous acidic solution with a base, extracting the basified solution with an organic solvent, separating the organic layer, drying and filtering, evaporating the organic layer to obtain an amorphous residue, and treating the amorphous residue with an organic solvent or mixture of organic solvents to obtain vasicine.

    摘要翻译： 本发明涉及一种用于从Adhatoda vasica生产式（1）的维生素的改进方法，所述方法包括以下步骤：在室温下用醇提取物萃取干燥和粉碎的叶子，将醇提取物浓缩 获得浓缩提取物，用有机酸水溶液处理和搅拌提取物2-24小时，用有机溶剂萃取酸溶液，分离有机层和酸性水层，用碱将酸性水溶液碱化，提取 碱性溶液与有机溶剂分离，分离有机层，干燥和过滤，蒸发有机层，得到无定形残渣，用有机溶剂或有机溶剂混合物处理无定形残余物，得到vasicine。

    Process for the preparation of maltol from plants belonging to the genus Abies
    4.
    发明授权
    Process for the preparation of maltol from plants belonging to the genus Abies 失效
    从属于Abies属的植物制备麦芽酚的方法

    公开(公告)号：US06384246B1

    公开(公告)日：2002-05-07

    申请号：US09792030

    申请日：2001-02-26

    申请人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Koneni Venkata Sashidhara ,  Vinayah Tripathi ,  Sushil Kumar

    发明人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Koneni Venkata Sashidhara ,  Vinayah Tripathi ,  Sushil Kumar

    IPC分类号： C07D30940

    CPC分类号： C07D309/40

    摘要： A process has been developed for production of a food flavoring compound maltol which comprises (a) extracting the dried and pulverized leaves of the plants belonging to the genus Abies with an alcohol at 20-40° C. and concentrating the solvent to obtain an alcoholic extract, (b) adsorbing the alcoholic extract with an adsorbent and drying the adsorbed material at a temperature ranging between 20-50° C., (d) partitioning of the adsorbed material between selected solvents consisting of aliphatic hydrocarbon and chlorinated solvent successively, (d) concentrating the chlorinated solvent to a residue and crystallizing it from a suitable organic solvent or mixtures of such solvents to get pure maltol.

    摘要翻译： 已经开发了用于生产食品香料化合物麦芽酚的方法，其包括（a）在20-40℃下用醇在20-40℃下提取属于Abies属的植物的干燥和粉碎的叶子并浓缩溶剂以获得酒精 提取物，（b）用吸附剂吸附醇提取物并在20-50℃的温度范围内干燥吸附的材料，（d）连续地将由脂族烃和氯化溶剂组成的选定溶剂之间的吸附材料分配（（ d）将氯化溶剂浓缩至残余物并将其从合适的有机溶剂或这些溶剂的混合物中结晶得到纯的麦芽酚。

    Process for the production of (−) 3,4-divanillyl tetrahydrofuran
    5.
    发明授权
    Process for the production of (−) 3,4-divanillyl tetrahydrofuran 失效
    生产（ - ）3,4-二苯乙烯基四氢呋喃的方法

    公开(公告)号：US06372922B1

    公开(公告)日：2002-04-16

    申请号：US09818278

    申请日：2001-03-27

    申请人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Vinayak Tripathi

    发明人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Vinayak Tripathi

    IPC分类号： C07D30712

    CPC分类号： C07D307/12

    摘要： The present invention relates to a process for the production of (−)3,4-divanillyl tetrahydrofiran of formula (2) which comprises (a) isolating) (−) secoisolariciresinol of formula (1) from the heartwood and roots of Taxus wallichiana by an improved process which consists of partitioning of the alcoholic extract of the heartwood and roots of T. wallichiana between water and chlorinated solvent, (b) extracting the chlorinated solvent extract with alkali and (c) isolating (−) secoisolariciresinol from the alkali extract upon neutralization with mineral acid and extracting with organic solvent and (d) crystallizing it from suitable organic solvent, (e) dissolving the isolated (−) secoisolariciresinol in suitable organic solvent and (f) reacting with triphenyl phosphine halide at 0-80° C. for 1-10 hours and (g) isolating (−) 3,4-divanillyl tetrahydrofuran by column chromatography.

    摘要翻译： 本发明涉及一种制备式（2）的（ - ）3,4-二氢化茚基四氢呋喃的方法，其包括（a）从红豆杉的心材和根中分离出（ - ）式（1）的（ - ）间二异硫氰菊酯 一种改进的方法，其包括在水和氯化溶剂之间分配心材的木材和根的酒精提取物，（b）用碱提取氯化溶剂提取物，和（c）从碱提取物中分离（ - ）二硫代亚铁氰菊酯， 用无机酸中和并用有机溶剂萃取，（d）从合适的有机溶剂中结晶，（e）将分离的（ - ）二异硫氰酸酯溶解在合适的有机溶剂中，和（f）在0-80℃与三苯基膦卤化物反应 （g）通过柱色谱法分离（ - ）3,4-二苯乙烯基四氢呋喃。

    Process for preparing brevifoliol
    6.
    发明授权
    Process for preparing brevifoliol 有权
    短纤维酚的制备方法

    公开(公告)号：US07579491B2

    公开(公告)日：2009-08-25

    申请号：US11548166

    申请日：2006-10-10

    申请人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Arvind Singh Negi ,  Ranganathan Santha Kumar Tirupadiripuliyur ,  Ankur Garg ,  Suman Preet Singh Khanuja

    发明人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Arvind Singh Negi ,  Ranganathan Santha Kumar Tirupadiripuliyur ,  Ankur Garg ,  Suman Preet Singh Khanuja

    IPC分类号： C07D305/00 ,  A61K36/13

    CPC分类号： C07C67/56 ,  C07C2603/30 ,  C07C69/78

    摘要： The present invention provides a process for production of an anticancer taxoid brevifoliol of the formula I from plants belonging to the genus Taxus by first extracting the dried and pulverized leaves of the plant with an alcohol preferably at a temperature in the range of 20-40° C. and then. concentrating the solvent to obtain an alcoholic extract. The alcoholic extract obtained is then adsorbed with an adsorbent and the resulting adsorbed material is then dried at a temperature ranging from 20-50° C. for 4-48 hours. The dried adsorbed material is then extracted with a combination of an aliphatic solvent and a chlorinated solvent successively and concentrated to obtain a residue. The residue is subjected to gross fractionation using column chromatography such as silica gel, florosil and silicic acid followed by chromatography with a suitable adsorbent to get brevifoliol.

    摘要翻译： 本发明提供了一种通过首先用醇优选在20-40℃的温度下提取植物的干燥和粉碎的叶来生产属于紫杉属的植物的式I的抗癌紫杉烷类短纤维醇的方法 C.然后。 浓缩溶剂以获得醇提取物。 然后将所得醇提物用吸附剂吸附，然后将所得吸附材料在20-50℃的温度范围内干燥4-48小时。 然后将干燥的吸附材料用脂肪族溶剂和氯化溶剂的组合连续萃取并浓缩，得到残余物。 使用柱色谱法如硅胶，佛罗里达和硅酸对残余物进行粗分馏，然后用合适的吸附剂进行色谱以得到短纤维醇。

    Process for the preparation of 10-deacetylbaccatin III
    7.
    发明授权
    Process for the preparation of 10-deacetylbaccatin III 失效
    制备10-脱乙酰基浆果赤霉素III的方法

    公开(公告)号：US06437154B1

    公开(公告)日：2002-08-20

    申请号：US09963768

    申请日：2001-09-28

    申请人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Vijay Kumar Mehta

    发明人： Sunil Kumar Chattopadhyay ,  Sachin Srivastava ,  Vijay Kumar Mehta

    IPC分类号： C07D30514

    CPC分类号： C07D305/14

    摘要： The present invention discloses a process for the conversion of a mixture of taxol analogues 7-xylosyl-10-deacetylbaccatin taxols of the formula 2 where R is C6H5, CH3C═CHCH3 or C5H11 into 10-deacetylbaccatin III of the formula 1 by dissolving the taxol analogue of formula 2 in a polar solvent, reacting the resultant solution with a base at a temperature of 20-50° C. for a time period in the range of 20-40 hours, and isolating 7-xyloxyl-10-deacetylbaccatin III, dissolving the 7-xylosyl-10-deacetylbaccatin III in a polar solvent, reacting the resultant solution with a periodate at 20-40° C. for a time period in the range of 20-40 hours to cleave the diol system of the xyloside into dialdehyde, treating the generated dialdehyde in an organic acid medium with salts of amine at 0-40° C. for 12-18 hours and isolating 10-deacetylbaccatin III of formula 1.

    摘要翻译： 本发明公开了一种将式2的紫杉醇类似物7-木糖基-10-脱乙酰基浆果赤霉素类紫杉醇的混合物，其中R为C6H5，CH3C = CHCH3或C5H11，转化为式1的10-脱乙酰基浆果赤霉素Ⅲ的方法， 式2在极性溶剂中，使所得溶液与碱在20-50℃的温度下反应20-40小时的时间，并分离7-木糖基-10-脱乙酰基浆果赤霉素III，将 7-木糖基-10-脱乙酰基浆果赤霉素III在极性溶剂中，使所得溶液与20-40℃的高碘酸盐反应20-40小时的时间段，将木糖苷的二醇体系切割成二醛， 在有机酸介质中用胺的盐在0-40℃处理生成的二醛12-18小时，并分离出式1的10-脱乙酰基浆果赤霉素III。

    Process for the production of 4-aryl-2 butanols from Taxus wallichiana
    9.
    发明授权
    Process for the production of 4-aryl-2 butanols from Taxus wallichiana 有权
    从Taxus wallichiana生产4-芳基-2丁醇的方法

    公开(公告)号：US06184367B2

    公开(公告)日：2001-02-06

    申请号：US09358113

    申请日：1999-07-21

    申请人： Sunil Kumar Chattopadhyay ,  Ram Prakash Sharma ,  Sushil Kumar

    发明人： Sunil Kumar Chattopadhyay ,  Ram Prakash Sharma ,  Sushil Kumar

    IPC分类号： C07C3982

    CPC分类号： C07H15/18 ,  C07C37/004 ,  C07H1/08 ,  C07C39/11

    摘要： The present invention provides a process for the production of two molecules of 4-aryl-2 butanols having the general formula 1 given below: Wherein R═H or glucose from the leaves of Taxus wallichiana, which comprises: (a) defatting air dried, pulverized leaves with aliphatic hydrocarbon solvents, (b) extracting the defatted leaves with chlorinated solvents and polar solvent successively at room temperature, (b) concentrating the chlorinated solvent soluble faction to a residue and treating the residue with aqueous solution of alkali and extracting with chlorinated solvents, (d) acidifying the alkali layer with mineral acid and extracting with ethyl acetate and concentrating the ethyl acetate phase to give compound of formula 1 where R═H, (e) concentrating the polar solvent fraction from step (b) to a residue and treating the residue with aqueous solution of alkali and extracting with chlorinated solvent, and (f) acidifying the alkali phase with mineral acid and extracting with ethyl acetate and concentrating the ethyl acetate to give compound of formula 1 where R=glucose.

    摘要翻译： 本发明提供了一种生产具有下列通式1的两分子的4-芳基-2丁醇的方法：其中R = H或来自红豆杉叶的葡萄糖，其包括：（a）将空气干燥脱脂， 用脂肪族烃溶剂粉碎叶片，（b）在室温下连续用氯化溶剂和极性溶剂萃取脱脂叶，（b）将氯化溶剂可溶部分浓缩至残留物，用碱水溶液处理残留物，用氯化物萃取 溶剂，（d）用无机酸酸化碱层并用乙酸乙酯萃取并浓缩乙酸乙酯相，得到其中R = H的式1化合物，（e）将步骤（b）的极性溶剂级分浓缩至残余物 并用碱水溶液处理残留物，用氯化溶剂萃取，（f）用无机酸酸化碱相，用乙酸乙酯萃取 并浓缩乙酸乙酯，得到其中R =葡萄糖的式1化合物。