公开(公告)号：US20110059904A1

公开(公告)日：2011-03-10

申请号：US12865239

申请日：2009-02-04

申请人： Surendra Sharma ,  Satyan Kalkunte

发明人： Surendra Sharma ,  Satyan Kalkunte

IPC分类号： C12Q1/02 ,  A61K38/12

CPC分类号： G01N33/5091 ,  G01N33/5032 ,  G01N2800/368

摘要： The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum samples from such subjects exhibit an ability to disrupt the architecture involving fetal trophoblasts and maternal endothelial cells in a three-dimensional, dual cell co-culture system provided herein, in contrast to normal pregnancy serum samples. Based on these distinctions, the assays are employed to predict pregnancy outcomes as early as first trimester.

摘要翻译： 本发明提供了用于预测由滋养层不良和/或胎盘缺血（包括先兆子痫）导致的妊娠紊乱的基于血清的，诊断性的生物测定法。 与正常妊娠血清样品相反，来自这些受试者的血清样品表现出在本文提供的三维双重细胞共培养系统中破坏涉及胎儿滋养细胞和母体内皮细胞的结构的能力。 基于这些区别，早在妊娠前期，采用测定法预测妊娠结局。

公开(公告)号：US09176120B2

公开(公告)日：2015-11-03

申请号：US12865239

申请日：2009-02-04

申请人： Surendra Sharma ,  Satyan Kalkunte

发明人： Surendra Sharma ,  Satyan Kalkunte

IPC分类号： C12Q1/02 ,  G01N33/50

CPC分类号： G01N33/5091 ,  G01N33/5032 ,  G01N2800/368

摘要： The invention provides serum-based, diagnostic, biological assays for predicting disorders of pregnancy resulting from poor trophoblast and/or placental ischemia, including preeclampsia. Serum samples from such subjects exhibit an ability to disrupt the architecture involving fetal trophoblasts and maternal endothelial cells in a three-dimensional, dual cell co-culture system provided herein, in contrast to normal pregnancy serum samples. Based on these distinctions, the assays are employed to predict pregnancy outcomes as early as first trimester.

摘要翻译： 本发明提供了用于预测由滋养层不良和/或胎盘缺血（包括先兆子痫）导致的妊娠紊乱的基于血清的，诊断性的生物测定法。 与正常妊娠血清样品相反，来自这些受试者的血清样品表现出在本文提供的三维双重细胞共培养系统中破坏涉及胎儿滋养细胞和母体内皮细胞的结构的能力。 基于这些区别，早在妊娠前期，采用测定法预测妊娠结局。

公开(公告)号：US20120101021A1

公开(公告)日：2012-04-26

申请号：US13147993

申请日：2010-02-05

申请人： Surendra Sharma ,  Satyan Kalkunte ,  Udo Markert

发明人： Surendra Sharma ,  Satyan Kalkunte ,  Udo Markert

IPC分类号： A61K38/00 ,  A61P9/12 ,  A61P15/00 ,  A61P29/00

CPC分类号： A61K38/1709 ,  A61K31/196 ,  A61K31/60 ,  A61K31/603 ,  A61K31/616 ,  A61K38/38 ,  A61K45/06 ,  C07K14/47 ,  G01N33/78 ,  A61K2300/00

摘要： This invention discloses a method of and composition for treating a PE-type disorder in a subject in need of such treatment comprising administering to the subject a pharmaceutical composition containing a therapeutically effective amount of a TTR polypeptide in admixture with a pharmaceutically acceptable vehicle.

摘要翻译： 本发明公开了一种用于治疗需要这种治疗的受试者中的PE型障碍的方法和组合物，包括向受试者施用含有治疗有效量的TTR多肽与药学上可接受的载体混合的药物组合物。