公开(公告)号：US20190382474A1

公开(公告)日：2019-12-19

申请号：US16362457

申请日：2019-03-22

申请人： Surface Oncology, Inc. ,  Adimab LLC

发明人： Jonathan HILL ,  Scott CHAPPEL ,  Michael GLADSTONE ,  Bianka PRINZ ,  Andrew LAKE ,  Christine MILLER ,  Kerry WHITE ,  Jing HUA ,  Pamela M. HOLLAND ,  Matthew RAUSCH ,  Devapregasan MOODLEY

IPC分类号： C07K16/24 ,  A61K45/06 ,  A61K39/395 ,  G01N33/68 ,  A61P35/00

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

公开(公告)号：US20190284295A1

公开(公告)日：2019-09-19

申请号：US16352589

申请日：2019-03-13

申请人： Surface Oncology, Inc. ,  Adimab, LLC

发明人： Scott CHAPPEL ,  Andrew LAKE ,  Michael WARREN ,  Austin DULAK ,  Erik DEVEREAUX ,  Pamela M. HOLLAND ,  Tauqeer ZAIDI ,  Matthew RAUSCH ,  Bianka Prinz ,  Nels P. NIELSON ,  Sonia DAS

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/85

摘要： The present disclosure relates to anti-CD39 antibodies, and antigen binding portions thereof and their use in treating cancer.

公开(公告)号：US20230042258A1

公开(公告)日：2023-02-09

申请号：US17714942

申请日：2022-04-06

申请人： Surface Oncology, Inc. ,  Adimab LLC

发明人： Jonathan HILL ,  Scott CHAPPEL ,  Michael GLADSTONE ,  Bianka PRINZ ,  Andrew LAKE ,  Christine MILLER ,  Kerry WHITE ,  Jing HUA ,  Pamela M. HOLLAND ,  Matthew RAUSCH ,  Devapregasan MOODLEY

IPC分类号： C07K16/24 ,  A61P35/00 ,  A61K39/395 ,  A61K45/06 ,  G01N33/68

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

公开(公告)号：US20200291114A1

公开(公告)日：2020-09-17

申请号：US16744733

申请日：2020-01-16

申请人： Erasmus University Medical Center ,  Surface Oncology, Inc.

发明人： Frank GROSVELD ,  Scott CHAPPEL ,  Jonathan HILL ,  Pamela M. HOLLAND ,  Andrew LAKE ,  Alison PATERSON

IPC分类号： C07K16/28

摘要： Disclosed herein are anti-CD47 antibody molecules, their manufacture and use in treating disorders associated with CD47 expression, for example, certain hematological cancers and solid tumors.

公开(公告)号：US20200277394A1

公开(公告)日：2020-09-03

申请号：US15931469

申请日：2020-05-13

申请人： Surface Oncology, Inc.

发明人： Scott CHAPPEL ,  Andrew LAKE ,  Michael WARREN ,  Austin DULAK ,  Erik DEVEREAUX ,  Pamela M. HOLLAND ,  Tauqeer ZAIDI ,  Matthew RAUSCH ,  Bianka Prinz ,  Nels P. NIELSON ,  Sonia DAS

IPC分类号： C07K16/28 ,  A61P35/00 ,  C12N15/85

摘要： The present disclosure relates to anti-CD39 antibodies, and antigen binding portions thereof and their use in treating cancer.

公开(公告)号：US20220259299A1

公开(公告)日：2022-08-18

申请号：US17413269

申请日：2019-09-25

申请人： SURFACE ONCOLOGY, INC.

发明人： Jonathan HILL ,  Scott CHAPPEL ,  Michael GLADSTONE ,  Bianka PRINZ ,  Andrew LAKE ,  Christine MILLER ,  Kerry WHITE ,  Jing HUA ,  Pamela M. HOLLAND ,  Matthew RAUSCH ,  Devapregasan MOODLEY ,  Gege TAN

IPC分类号： C07K16/24 ,  C07K16/28 ,  A61P37/04 ,  A61P35/00 ,  G01N33/574

摘要： The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

公开(公告)号：US20210095041A1

公开(公告)日：2021-04-01

申请号：US17021223

申请日：2020-09-15

申请人： Surface Oncology, Inc.

发明人： Scott CHAPPEL ,  Andrew LAKE ,  Michael WARREN ,  Austin DULAK ,  Erik DEVEREAUX ,  Pamela M. HOLLAND ,  Tauqeer ZAIDI ,  Matthew RAUSCH ,  Bianka Prinz ,  Nels P. NIELSON ,  Sonia DAS ,  Alison M. O'Neill

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  A61K45/06 ,  A61K31/337 ,  A61K31/7068

摘要： The invention provides anti-CD39 antibody compositions and their use in treating cancer.

公开(公告)号：US20220372160A1

公开(公告)日：2022-11-24

申请号：US17642824

申请日：2020-09-15

申请人： Surface Oncology, Inc.

发明人： Scott CHAPPEL ,  Andrew LAKE ,  Michael WARREN ,  Austin DULAK ,  Erik DEVEREAUX ,  Pamela M. HOLLAND ,  Tauqeer ZAIDI ,  Matthew RAUSCH ,  Bianka Prinz ,  Nels P. NIELSON ,  Sonia DAS ,  Alison M. O'Neill

IPC分类号： C07K16/28 ,  A61P35/00

摘要： The invention provides anti-CD39 antibody compositions and their use in treating cancer. In some embodiments, an isolated anti-CD39 antibody is provided. Such an isolated anti-CD39 antibody binds to human CD39, wherein the antibody is optionally fully human or humanized. In some embodiments, the disclosure provides a method of enhancing, increasing and/or sustaining an anti-tumor immune response in a subject comprising administering the antibody or composition described herein to a subject having a tumor.

公开(公告)号：US20210363268A1

公开(公告)日：2021-11-25

申请号：US16980271

申请日：2019-03-13

申请人： Surface Oncology, Inc.

发明人： Scott CHAPPEL ,  Andrew LAKE ,  Michael WARREN ,  Austin DULAK ,  Erik DEVEREAUX ,  Pamela M. HOLLAND ,  Tauqeer ZAIDI ,  Matthew RAUSCH ,  Bianka Prinz ,  Nels P. NIELSON ,  Sonia DAS

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  G01N33/573

摘要： The present disclosure relates to anti-CD39 antibodies, and antigen binding portions thereof and their use in treating cancer.