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1.发明申请LONG-ACTING INJECTABLE MOXIDECTIN FORMULATIONS AND NOVEL MOXIDECTIN CRYSTAL FORMS 有权长效注射胶体制剂和新型MOXIDECTIN晶体形式公开(公告)号：US20130143956A1
公开(公告)日：2013-06-06
申请号：US13690185
申请日：2012-11-30
IPC分类号： A61K31/365
CPC分类号： A61K31/365 , A61K9/0024 , A61P33/00 , C07D493/22
摘要： This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.
摘要翻译： 本发明提供了莫昔克丁的新型抗寄生虫和杀虫剂形式，包括长效聚合物植入物。 所得化合物可用于兽用组合物，其用于治疗，控制和预防动物内和外寄生虫感染。
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2.发明申请LONG-ACTING INJECTABLE MOXIDECTIN FORMULATIONS AND NOVEL MOXIDECTIN CRYSTAL FORMS 有权长效注射胶体制剂和新型MOXIDECTIN晶体形式公开(公告)号：US20140323559A1
公开(公告)日：2014-10-30
申请号：US14225187
申请日：2014-03-25
IPC分类号： A61K31/365
CPC分类号： A61K31/365 , A61K9/0024 , A61P33/00 , C07D493/22
摘要： This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.
摘要翻译： 本发明提供了莫昔克丁的新型抗寄生虫和杀虫剂形式，包括长效聚合物植入物。 所得化合物可用于兽用组合物，其用于治疗，控制和预防动物内和外寄生虫感染。
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3.发明授权Long-acting injectable moxidectin formulations and novel moxidectin crystal forms 有权长效注射莫昔克丁配方和新型莫昔克丁晶体形式公开(公告)号：US09044453B2
公开(公告)日：2015-06-02
申请号：US14225187
申请日：2014-03-25
IPC分类号： A61K31/365 , C07D493/22
CPC分类号： A61K31/365 , A61K9/0024 , A61P33/00 , C07D493/22
摘要： This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.
摘要翻译： 本发明提供了莫昔克丁的新型抗寄生虫和杀虫剂形式，包括长效聚合物植入物。 所得化合物可用于兽用组合物，其用于治疗，控制和预防动物内和外寄生虫感染。
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4.发明授权Long-acting injectable moxidectin formulations and novel moxidectin crystal forms 有权长效注射莫昔克丁配方和新型莫昔克丁晶体形式公开(公告)号：US08715711B2
公开(公告)日：2014-05-06
申请号：US13690185
申请日：2012-11-30
CPC分类号： A61K31/365 , A61K9/0024 , A61P33/00 , C07D493/22
摘要： This invention provides for novel antiparasitic and pesticidal forms of moxidectin, including a long-acting polymeric implant. The resulting compounds may be used in veterinary compositions which are used in treating, controlling and preventing of endo- and ectoparasite infections in animals.
摘要翻译： 本发明提供了莫昔克丁的新型抗寄生虫和杀虫剂形式，包括长效聚合物植入物。 所得化合物可用于兽用组合物，其用于治疗，控制和预防动物内和外寄生虫感染。
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公开(公告)号：US5977068A
公开(公告)日：1999-11-02
申请号：US808694
申请日：1991-12-16
IPC分类号： A61K38/27 , A61K38/04 , A61K47/00 , A61K47/02 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/16 , A61K47/18 , A61K47/22 , A61P15/00 , A61K38/00
CPC分类号： A61K9/0019 , A61K38/27 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/22 , Y10S930/12
摘要： The present invention relates to compositions of growth hormones and preservatives which do not interfere with the activity of the growth hormone.
摘要翻译： 本发明涉及不干扰生长激素活性的生长激素和防腐剂的组合物。
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6.发明授权Stabilization of somatotropins and other proteins by modification of cysteine residues 失效通过修饰半胱氨酸残基稳定生长激素和其他蛋白质
公开(公告)号：US5951972A
公开(公告)日：1999-09-14
申请号：US383621
申请日：1995-02-06
申请人： Michael Joseph Daley , Brian Lee Buckwalter , Susan Mancini Cady , Hong-Ming Shieh , Peter Bohlen , Andrew P. Seddon
发明人： Michael Joseph Daley , Brian Lee Buckwalter , Susan Mancini Cady , Hong-Ming Shieh , Peter Bohlen , Andrew P. Seddon
CPC分类号： A61K47/48215 , C07K14/50 , C07K14/503
摘要： The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing the derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.
摘要翻译： 本发明涉及生理活性衍生的天然和重组哺乳动物和人类蛋白质和多肽。 本发明提供用于衍生自然和重组衍生的蛋白质或含有半胱氨酸残基的多肽的化学方法，天然或通过位点特异性突变体。 配制含有衍生化蛋白质和/或多肽的药物组合物被配制以提供以前难以实现的这种蛋白质和/或多肽的稳定的长效组合物。
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公开(公告)号：USD428136S
公开(公告)日：2000-07-11
申请号：US104120
申请日：1999-04-28
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公开(公告)号：US06340671B1
公开(公告)日：2002-01-22
申请号：US08263574
申请日：1994-06-22
申请人： Susan Mancini Cady , William David Steber , Phillip Wayne Hayes , Mary Ehlers Doscher , Kurt Allen Schwinghammer
发明人： Susan Mancini Cady , William David Steber , Phillip Wayne Hayes , Mary Ehlers Doscher , Kurt Allen Schwinghammer
IPC分类号： A61K3170
CPC分类号： A61K31/70 , A61K9/1617 , A61K31/35 , Y10S514/964 , Y10S514/965
摘要： The invention relates to certain stable microsphere compositions containing a fat, a wax or a mixture thereof; an active ingredient selected from LL-F28249&agr;-&lgr; compounds, 23-oxo or 23-imino derivatives of LL-F28249&agr;-&lgr; compounds, milbemycin compounds and avermectin compounds; an antioxidant and, optionally, an oil, a semi-soft fat, a fatty acid derivative or mixture thereof. The invention also relates to a method for introducing and maintaining levels of the active compound in the blood of warm-blooded animals for extended periods of time and for the prevention or treatment of infections and infestations caused by helminths, nematodes, acarids and endo- and ectoparasitic arthropods in warm-blooded animals by the parenteral administration of compositions of the invention.
摘要翻译： 本发明涉及含有脂肪，蜡或其混合物的某些稳定的微球组合物; 选自LL-F28249α-羔羊化合物的活性成分，LL-F28249α-羔羊化合物的23-氧代或23-亚氨基衍生物，米尔倍霉素化合物和除虫菌素化合物; 抗氧化剂和任选的油，半软脂肪，脂肪酸衍生物或其混合物。 本发明还涉及一种用于在温血动物的血液中长时间引入和维持活性化合物的水平并用于预防或治疗由蠕虫，线虫，螨虫和内含物引起的感染和侵袭的方法 通过肠胃外给药本发明的组合物在温血动物中的外寄生节肢动物。
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9.发明授权Stabilization of fibroblast growth factors by modification of cysteine residues 失效通过修饰半胱氨酸残基稳定成纤维细胞生长因子
公开(公告)号：US6010999A
公开(公告)日：2000-01-04
申请号：US459906
申请日：1995-06-02
申请人： Michael Joseph Daley , Brian Lee Buckwalter , Susan Mancini Cady , Hong-Ming Shieh , Peter Bohlen , Andrew P. Seddon
发明人： Michael Joseph Daley , Brian Lee Buckwalter , Susan Mancini Cady , Hong-Ming Shieh , Peter Bohlen , Andrew P. Seddon
CPC分类号： A61K47/48215 , C07K14/50 , C07K14/503
摘要： The present invention relates to physiologically-active derivatized natural and recombinant mammalian and human proteins and polypeptides. The invention provides chemical methods for derivatizing natural and recombinantly-derived proteins or polypeptides containing cysteine residues, either naturally or through site specific mutageneses. The pharmaceutical compositions containing said derivatized proteins and/or polypeptides are formulated to provide stable, long-acting compositions of such proteins and/or polypeptides, previously difficult to achieve.
摘要翻译： 本发明涉及生理活性衍生的天然和重组哺乳动物和人类蛋白质和多肽。 本发明提供用于衍生自然和重组衍生的蛋白质或含有半胱氨酸残基的多肽的化学方法，天然或通过位点特异性突变体。 将含有所述衍生化蛋白质和/或多肽的药物组合物配制成提供以前难以实现的这种蛋白质和/或多肽的稳定的长效组合物。
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10.发明申请公开(公告)号：US20130203692A1
公开(公告)日：2013-08-08
申请号：US13754969
申请日：2013-01-31
IPC分类号： A61K45/06 , C07D261/04 , A61K31/27 , A61K31/7048 , A61K31/365 , A61K31/42 , A61K31/4985
CPC分类号： A61K31/42 , A01N43/80 , A23K20/00 , A61K9/0056 , A61K9/0068 , A61K31/194 , A61K31/27 , A61K31/325 , A61K31/365 , A61K31/437 , A61K31/4985 , A61K31/7048 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/32 , A61K47/36 , A61K47/42 , A61K47/44 , C07D261/04 , A61K2300/00
摘要： This invention relates to oral veterinary compositions for combating ectoparasites and endoparasites in animals, comprising at least one systemically-acting active agent in combination with a pharmaceutically acceptable carrier. This invention also provides for improved methods for eradicating, controlling, and preventing parasite infections and infestations in an animal comprising administering the compositions of the invention to the animal in need thereof.
摘要翻译： 本发明涉及用于对抗动物体内寄生虫和内寄生虫的口服兽药组合物，其包含与药学上可接受的载体组合的至少一种全身作用的活性剂。 本发明还提供了用于消除，控制和预防动物中的寄生虫感染和侵染的改进方法，包括将本发明的组合物施用于有需要的动物。
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