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    Implant compositions containing a biologically active protein, peptide or polypeptide
    9.
    发明授权
    Implant compositions containing a biologically active protein, peptide or polypeptide 失效
    含有生物活性蛋白质，肽或多肽的植入物组合物

    公开(公告)号：US5801141A

    公开(公告)日：1998-09-01

    申请号：US456167

    申请日：1995-05-31

    申请人： William David Steber ,  Susan Mancini Cady ,  David Farley Johnson ,  Theresa Rice Haughey

    发明人： William David Steber ,  Susan Mancini Cady ,  David Farley Johnson ,  Theresa Rice Haughey

    IPC分类号： A61K38/27 ,  A61K9/24 ,  A61K38/18

    CPC分类号： A61K38/27

    摘要： The invention relates to implants for the parenteral administration of an essentially uniform and continuous amount of a biologically active protein, peptide or polypeptide over an extended period of time which comprises a compacted, indented and partially coated composition containing from one to three layers of a homogeneous core mixture comprising about 20% to about 80% of a biologically active protein, a peptide or a polypeptide; about 10% to about 75% of a fat, a wax or a mixture thereof; 0% to about 25% of a buffer, a salt, a sugar or a mixture thereof; 0% to about 15% of a filler, on a weight basis of the total weight of the core mixture. The partial coating of a semipermeable material comprises about 5% to about 50%, on a weight basis of the total weight of the implant. The invention also relates to methods for increasing and maintaining elevated blood levels of biologically active proteins, peptides and polypeptides in animals by the administration of said implants.

    摘要翻译： 本发明涉及用于在延长的时间段内胃肠外施用基本上均匀和连续量的生物活性蛋白质，肽或多肽的植入物，其包含压实的，凹进的和部分涂覆的组合物，其含有一至三层均质 核心混合物，其包含约20％至约80％的生物活性蛋白质，肽或多肽; 约10％至约75％的脂肪，蜡或其混合物; 0％至约25％的缓冲液，盐，糖或其混合物; 0％至约15％的填料，以核心混合物的总重量为基准。 半透膜材料的部分涂覆包括约5％至约50％，基于植入物总重量的重量。 本发明还涉及通过施用所述植入物来增加和维持动物中生物活性蛋白质，肽和多肽的血液水平升高的方法。