公开(公告)号：US20070148718A1

公开(公告)日：2007-06-28

申请号：US11465403

申请日：2006-08-17

申请人： Susan Medghalchi ,  Jennifer Aldrich

发明人： Susan Medghalchi ,  Jennifer Aldrich

IPC分类号： G01N33/53 ,  C07K16/40 ,  C12N5/06

CPC分类号： C07K16/40 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/91045

摘要： The disclosed invention relates to monoclonal antibodies (MAbs) which recognize human fatty acid synthase (hFAS) and are distinct from previously known anti-hFAS antibodies. Compositions, devices and kits comprising the MAbs are provided along with methods of using the MAbs in a variety of applications.

摘要翻译： 所公开的本发明涉及识别人脂肪酸合酶（hFAS）的单克隆抗体（MAb），并且与先前已知的抗hFAS抗体不同。 提供包含MAb的组合物，装置和试剂盒以及在各种应用中使用MAb的方法。

公开(公告)号：US20070231840A1

公开(公告)日：2007-10-04

申请号：US11234752

申请日：2005-09-23

申请人： Beverly Mangold ,  Jennifer Aldrich ,  William Nelson

发明人： Beverly Mangold ,  Jennifer Aldrich ,  William Nelson

IPC分类号： G01N33/569 ,  C07K16/12

CPC分类号： C07K16/1278 ,  G01N33/56911

摘要： The invention relates to a Bacillus spore specific antigen. Compositions and methods relating to the antigen are provided along with antibodies against the antigen. The antigen is specific for Bacillus spores relative to the vegetative form of the cells. The antigen is detectable on ungerminated spores. The antibodies may be used to detect the presence of Bacillus spores by use of methods provided herein. The invention also relates to articles of manufacture as well as kits comprising the antibodies which may be used in the detection methods of the invention.

摘要翻译： 本发明涉及芽孢杆菌特异性抗原。 提供与抗原相关的组合物和方法以及针对抗原的抗体。 相对于细胞的营养形式，抗原对芽孢杆菌是特异性的。 抗原在未发芽的孢子上可检测。 抗体可用于通过使用本文提供的方法检测芽孢杆菌的存在。 本发明还涉及制品以及包含可用于本发明检测方法的抗体的试剂盒。

公开(公告)号：US20060286612A1

公开(公告)日：2006-12-21

申请号：US11127435

申请日：2005-05-11

申请人： Beverly Mangold ,  Jennifer Aldrich

发明人： Beverly Mangold ,  Jennifer Aldrich

IPC分类号： G01N33/554 ,  C07K16/12

CPC分类号： G01N33/56911 ,  C07K16/1278 ,  G01N2333/32

摘要： The invention relates to spore specific antibodies. Compositions and methods relating to the antibodies are provided along with the hybridomas that produce the antibodies. The antibodies are specific for the spores of B. anthracis relative to the vegetative form of the cells. The antibodies are also specific for the spores relative to other Bacillus spores and cells. The antibodies may be used to detect the presence of B. anthracis spores by use of methods provided herein. The invention also relates to articles of manufacture as well as kits comprising these antibodies which may be used in the detection methods of the invention.

摘要翻译： 本发明涉及孢子特异性抗体。 与抗体相关的组合物和方法与产生抗体的杂交瘤一起提供。 抗体对于炭疽杆菌的孢子相对于细胞的营养形式是特异性的。 抗体对于孢子相对于其他芽孢杆菌孢子和细胞也是特异性的。 抗体可用于通过使用本文提供的方法来检测炭疽芽孢杆菌的存在。 本发明还涉及可用于本发明的检测方法的制造方法以及包含这些抗体的试剂盒。