公开(公告)号：US20070148718A1

公开(公告)日：2007-06-28

申请号：US11465403

申请日：2006-08-17

申请人： Susan Medghalchi ,  Jennifer Aldrich

发明人： Susan Medghalchi ,  Jennifer Aldrich

IPC分类号： G01N33/53 ,  C07K16/40 ,  C12N5/06

CPC分类号： C07K16/40 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/91045

摘要： The disclosed invention relates to monoclonal antibodies (MAbs) which recognize human fatty acid synthase (hFAS) and are distinct from previously known anti-hFAS antibodies. Compositions, devices and kits comprising the MAbs are provided along with methods of using the MAbs in a variety of applications.

摘要翻译： 所公开的本发明涉及识别人脂肪酸合酶（hFAS）的单克隆抗体（MAb），并且与先前已知的抗hFAS抗体不同。 提供包含MAb的组合物，装置和试剂盒以及在各种应用中使用MAb的方法。

公开(公告)号：US20090005435A1

公开(公告)日：2009-01-01

申请号：US11597538

申请日：2005-05-25

申请人： Jill M. Sturdivant ,  Craig Townsend ,  Susan Medghalchi

发明人： Jill M. Sturdivant ,  Craig Townsend ,  Susan Medghalchi

IPC分类号： A61K31/381 ,  C07D333/32 ,  A61P35/00 ,  A61P3/04

CPC分类号： C07D333/32

摘要： A pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula (II), wherein R1 and R2, the same or different from each other, are H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CH2CORS, —CH2C(O)NRS, —C(O)R5, or —CH2OR5, and can optionally contain halogen atoms, where R5 is a C1-C12 alkyl group. R3 and R4, the same or different from each other, are H, C1-C20 alkyl cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl.

摘要翻译： 一种药物组合物，其包含药物稀释剂和式（II）化合物，其中R 1和R 2彼此相同或不同，为H，C 1 -C 20烷基，环烷基，烯基，芳基，芳烷基或烷芳基，-CH 2 CORS ，-CH 2 C（O）NRS，-C（O）R 5或-CH 2 OR 5，并且可任选地含有卤素原子，其中R 5是C 1 -C 12烷基。 R 3和R 4彼此相同或不同，为H，C 1 -C 20烷基环烷基，烯基，芳基，芳基烷基或烷基芳基。

公开(公告)号：US20060247302A1

公开(公告)日：2006-11-02

申请号：US10520505

申请日：2003-07-09

申请人： Francis Kuhajda ,  Susan Medghalchi ,  Jill McFadden ,  Jagan Thupari

发明人： Francis Kuhajda ,  Susan Medghalchi ,  Jill McFadden ,  Jagan Thupari

IPC分类号： A61K31/381 ,  C07D333/32

CPC分类号： C07D409/12 ,  C07D333/32

摘要： A pharmaceutical composition comprising a phamaceurtical diluent and a compound of formula IV wherein R21═H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, —CH2OR25, —C(O)R25, —CO(O)R25, —C(O)NR25R26, —CH2C(O)R25, or —CH2C(O)NHR25, where R25 and R26 are each independently H, C1-C10 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, optionally containing one or more halogen atoms. R22 ═—OH, —OR27, —OCH2C(O)R27, —OCH2C(O)NHR27, —OC(O)R27, —OC(O)OR27, —OC(O)NHNH—R5, or —OC(O)NR27R28, where R27 and R28 are each independently H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, and where R27 and R28 can each optionally contain halogen atoms; R23 and R24, the same or different from each other, are C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl. Methods of using such formulations for the treatment of cancer, to effect weight loss, to treat microbially-based infections, to inhibit neuropeptide-Y and/or fatty acid synthase, and to stimulate CPT-1.

公开(公告)号：US08247188B2

公开(公告)日：2012-08-21

申请号：US11465403

申请日：2006-08-17

申请人： Susan Medghalchi ,  Jennifer L. Aldrich

发明人： Susan Medghalchi ,  Jennifer L. Aldrich

IPC分类号： C07K16/40 ,  C07K16/30 ,  C12N5/20 ,  G01N33/543 ,  G01N33/573 ,  G01N33/574 ,  G01N33/577 ,  A61K39/395

CPC分类号： C07K16/40 ,  G01N33/573 ,  G01N33/574 ,  G01N2333/91045

摘要： The disclosed invention relates to monoclonal antibodies (MAbs) which recognize human fatty acid synthase (hFAS) and are distinct from previously known anti-hFAS antibodies. Compositions, devices and kits comprising the MAbs are provided along with methods of using the MAbs in a variety of applications.

摘要翻译： 所公开的本发明涉及识别人脂肪酸合酶（hFAS）的单克隆抗体（MAb），并且与先前已知的抗hFAS抗体不同。 提供包含MAb的组合物，装置和试剂盒以及在各种应用中使用MAb的方法。

公开(公告)号：US20110124021A1

公开(公告)日：2011-05-26

申请号：US12742910

申请日：2008-11-13

申请人： Susan Medghalchi

发明人： Susan Medghalchi

IPC分类号： C12Q1/48 ,  C07K16/40

CPC分类号： G01N33/574 ,  G01N33/573 ,  G01N2800/56

摘要： The disclosed invention relates to the detection of phosphorylated fatty acid synthase as a diagnostic and a component in the identification and treatment of cancer. The disclosed methods permit early and accurate diagnosis of cancer to enable more effective therapy and to enhance patient survival and quality of life.

摘要翻译： 所公开的发明涉及磷酸化脂肪酸合酶的检测作为癌症的鉴定和治疗中的诊断和成分。 所公开的方法允许对癌症的早期和准确诊断，以实现更有效的治疗并增加患者的生存和生活质量。

公开(公告)号：US20060241177A1

公开(公告)日：2006-10-26

申请号：US10519804

申请日：2003-07-01

申请人： Francis Kuhadja ,  Susan Medghalchi ,  Jagan Thupari ,  Craig Townsend ,  Jill McFadden

发明人： Francis Kuhadja ,  Susan Medghalchi ,  Jagan Thupari ,  Craig Townsend ,  Jill McFadden

IPC分类号： A61K31/365 ,  C07D305/12

CPC分类号： C07D307/33 ,  C07D307/58 ,  C07D307/68

摘要： Pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IX: R29═H, or C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, ═CHR31, —C(O)OR31, —C(O)R31, —CH2C(O)OR31, CH2C(O)NHR31, where R31 is H or C1-C10 alkyl, cycloalkyl, or alkenyl; R30═C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl; X5═—OR32, or NHR32, Where R32 is H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, the R32 group optionally containing a carbonyl group, a carboxyl group, a carboxyamide group, an alcohol group, or an ether group, the R32 group further optionally containing one or more halogen atoms; with the proviso that when R29 is ═CH2, then X5 is not OH. Also disclosed are compounds within the scope of the formula IX, as well as uses of the pharmaceutical compositions for weight loss, anti-microbial and anti-cancer applications, inhibition of fatty acid synthase and neuropeptide-Y, and the stimulation of the activity of carnitine palmitoyl transferase-1.

摘要翻译： 包含药物稀释剂和式IX化合物的药物组合物：R 29 -H或C 1 -C 20烷基，环烷基，烯基 ，芳基，芳烷基或烷基芳基，-CHR 31，-C（O）OR 31，-C（O）R 31， - CH 2 C（O）OR 31，CH 2 C（O）NHR 31，其中R SUP > 31是H或C 1 -C 10烷基，环烷基或链烯基; 烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基;其中R 1，R 2，R 2，R 3， 其中R 32为H，C 1〜S 12，或其中R 32为H，C 1〜 烷基，环烷基，烯基，芳基，芳烷基或烷基芳基，任选含有羰基，羧基，羧酰胺的R 32基团 基团，醇基团或醚基团，R 32基团还任选地含有一个或多个卤素原子; 条件是当R 29为-CH 2时，则X 5不是OH。 还公开了式IX范围内的化合物，以及药物组合物用于体重减轻，抗微生物和抗癌应用，抑制脂肪酸合酶和神经肽Y的用途以及刺激活性 肉碱棕榈酰转移酶-1。