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    Biologically active substance-secreting hybrid gel
    1.
    发明授权
    Biologically active substance-secreting hybrid gel 失效
    生物活性物质分泌杂交凝胶

    公开(公告)号：US06485721B1

    公开(公告)日：2002-11-26

    申请号：US08428822

    申请日：1995-04-25

    申请人： Susumu Yoshida ,  R. Andrew Cuthbertson ,  Katsutoshi Yoshizato

    发明人： Susumu Yoshida ,  R. Andrew Cuthbertson ,  Katsutoshi Yoshizato

    IPC分类号： A01N6300

    CPC分类号： A61K48/00 ,  A61K2035/126

    摘要： The present invention provides a biologically active substance secreting hybrid gel, which consists essentially of a biopolymeric gel and cells containing an expression vector with a gene encoding the biologically active substance to produce the substance. According to the present invention, it is possible to develop a gene therapy by skin transplantation allowing stable drug medication for a long time; alleviating pains of patients; and allowing fine adjustment of the dosage and control of genes externally without using retrovirusderived vector that tend to invoke the risk of mutation to wild types as in the conventional prescription.

    摘要翻译： 本发明提供一种生物活性物质分泌型混合凝胶，其主要由生物聚合物凝胶和含有表达载体的细胞组成，所述表达载体具有编码生物活性物质的基因以产生该物质。 根据本发明，可以通过皮肤移植开发长期稳定药物治疗的基因治疗; 减轻患者的痛苦; 并且允许在外部对基因的剂量和控制进行微调，而不使用如常规处方那样倾向于将突变风险引入野生型的逆转录病毒载体。