公开(公告)号：US5490990A

公开(公告)日：1996-02-13

申请号：US78824

申请日：1993-06-21

申请人： Sven Grabowski ,  Astrid Kah-Helbig ,  Axel Sanner ,  Kurt Wendel

发明人： Sven Grabowski ,  Astrid Kah-Helbig ,  Axel Sanner ,  Kurt Wendel

IPC分类号： A61K9/16 ,  A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K9/30 ,  A61K9/50 ,  A61K47/04 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

CPC分类号： A61K9/2059 ,  A61K9/2027 ,  A61K9/2009 ,  A61K9/2054

摘要： A process for the production of solid pharmaceutical depot forms by application of a reconstituted aqueous dispersion of a pharmaceutically acceptable binder to a core which contains active substance or by wet granulation of the pharmaceutical active substance with such a binder dispersion or by direct tableting of an active substance with the redispersible binder powder, wherein the binder has been obtained by emulsion polymerization and subsequent spray drying of the resulting aqueous dispersion with a water-soluble pharmaceutically acceptable spraying aid with a glass transition temperature of at least 60.degree. C. and with or without a pharmaceutically acceptable antiblocking agent.

摘要翻译： 通过将药学上可接受的粘合剂的重构水性分散体应用于含有活性物质的核心或通过用这种粘合剂分散体湿法制粒药物活性物质或通过直接压片活性物质来生产固体药物贮库的方法 物质与可再分散的粘合剂粉末，其中粘合剂已经通过乳液聚合获得并随后用水溶性药学上可接受的喷雾助剂喷雾干燥所得水性分散体，玻璃化转变温度至少为60℃，有或没有 药学上可接受的防粘连剂。

公开(公告)号：US5326586A

公开(公告)日：1994-07-05

申请号：US957375

申请日：1992-10-07

申请人： Sven Grabowski ,  Kurt Wendel ,  Astrid Kah-Helbig

发明人： Sven Grabowski ,  Kurt Wendel ,  Astrid Kah-Helbig

IPC分类号： A61K9/20 ,  A61K9/22 ,  A61K9/28 ,  A61K9/32 ,  A61K9/36 ,  A61K47/30 ,  A61K9/00

CPC分类号： A61K9/205 ,  A61K9/2027 ,  A61K9/2846 ,  A61K9/286

摘要： A process for coating drug forms by application of an aqueous dispersion which contains as binder a redispersed latex of an emulsion polymer onto the drug form and evaporating the water at a temperature at which the latex particles form a film, comprises employing a polymer dispersion which has been prepared by emulsion polymerization of one part by weight of at least one ethylenically unsaturated polymerizable monomer, by means of initiators which provide free radicals, in the presence of from 0.1 to 2 parts by weight of saccharified starch, and from 0 to 5% by weight, based on the monomer or monomers, of a surfactant, with or without further conventional additives, drying to a powder and redispersing in water.

摘要翻译： 通过应用含水分散体涂覆药物形式的方法，该水性分散体含有作为粘合剂的乳液聚合物的再分散胶乳到药物形式上并在胶乳颗粒形成膜的温度下蒸发水，包括使用聚合物分散体，其具有 通过在0.1至2重量份的糖化淀粉和0至5重量％的糖化淀粉存在下，通过使用1重量份的至少一种烯键式不饱和可聚合单体，通过提供自由基的引发剂， 重量，基于单体或单体的表面活性剂，含或不含其它常规添加剂，干燥至粉末并再分散于水中。