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公开(公告)号：US08552200B2
公开(公告)日：2013-10-08
申请号：US13276464
申请日：2011-10-19
申请人： Sven Kühnert , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder , Simon Lucas
发明人： Sven Kühnert , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder , Simon Lucas
IPC分类号： C07D213/72 , A61K31/44
CPC分类号： C07D401/04 , C07D213/82 , C07D401/14 , C07D405/12 , C07D413/04 , C07D413/14
摘要： Substituted 6-amino-nicotinamides, pharmaceutical compositions containing these compounds and also use of these compounds in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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2.发明授权Substituted 2-mercaptoquinoline-3-carboxamides as KCNQ2/3 modulators 有权取代的2-巯基喹啉-3-甲酰胺作为KCNQ2 / 3调节剂公开(公告)号：US08399673B2
公开(公告)日：2013-03-19
申请号：US13523955
申请日：2012-06-15
IPC分类号： C07D215/54 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D409/12 , C07D215/54
摘要： The invention relates to substituted 2-mercaptoquinoline-3-carboxamides, methods for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
摘要翻译： 本发明涉及取代的2-巯基喹啉-3-甲酰胺，其制备方法，含有这些化合物的药物以及这些化合物在制备药物中的用途。
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3.发明授权Substituted 2-amino-quinoline-3-carboxamides as KCNQ2/3 modulators 有权取代的2-氨基 - 喹啉-3-甲酰胺作为KCNQ2 / 3调节剂公开(公告)号：US08470852B2
公开(公告)日：2013-06-25
申请号：US13218536
申请日：2011-08-26
IPC分类号： A61K31/47 , A61K31/4709 , A61P13/00 , A61P25/00 , A61P25/06 , A61P25/08 , A61P25/22 , A61P25/30 , C07D215/38 , C07D401/02
CPC分类号： C07D215/54 , C07D401/04
摘要： The invention relates to substituted 2-amino-quinoline-3-carboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及取代的2-氨基 - 喹啉-3-甲酰胺，含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或病症的这些化合物。
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4.发明申请公开(公告)号：US20120053205A1
公开(公告)日：2012-03-01
申请号：US13218512
申请日：2011-08-26
IPC分类号： A61K31/47 , A61P29/00 , A61P13/02 , A61P25/00 , A61P25/24 , A61P25/08 , A61P25/06 , C07D215/58 , A61P25/22
CPC分类号： C07D215/54 , A61K31/47 , A61K45/06 , C07D215/56 , C07D409/12
摘要： The invention relates to substituted 2-oxy-quinoline-3-carboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及取代的2-氧 - 喹啉-3-甲酰胺，含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或病症的这些化合物。
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5.发明授权Substituted 1-oxo-dihydroisoquinoline-3-carboxamides as KCNQ2/3 modulators 失效取代的1-氧代 - 二氢异喹啉-3-甲酰胺，为KCNQ2 / 3调节剂公开(公告)号：US08618129B2
公开(公告)日：2013-12-31
申请号：US13222023
申请日：2011-08-31
IPC分类号： C07D217/26 , A61K31/472
CPC分类号： C07D217/26 , A61K31/472
摘要： The invention relates to substituted 1-oxo-dihydroisoquinoline-3-carboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及取代的1-氧代 - 二氢异喹啉-3-甲酰胺，含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或病症的这些化合物。
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6.发明申请Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as KCNQ2/3 modulators 有权取代的2-氧代和2-硫代二氢喹啉-3-甲酰胺作为KCNQ2 / 3调节剂公开(公告)号：US20120053206A1
公开(公告)日：2012-03-01
申请号：US13218579
申请日：2011-08-26
IPC分类号： A61K31/4704 , A61K31/4709 , C07D405/12 , A61P25/04 , A61P25/14 , A61P13/00 , A61P25/22 , A61P25/18 , A61P25/06 , C07D215/54 , A61P25/08
CPC分类号： C07D215/54 , C07D405/04
摘要： The invention relates to substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及取代的2-氧代 - 和2-硫代 - 二氢喹啉-3-甲酰胺与含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或病症的这些化合物。
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7.发明申请SUBSTITUTED 2-MERCAPTOQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS 审中-公开作为KCNQ2 / 3调节剂的2-MERCAPTOQUINOLINE-3-CARBOXAMID公开(公告)号：US20100234372A1
公开(公告)日：2010-09-16
申请号：US12720864
申请日：2010-03-10
IPC分类号： A61K31/5377 , C07D409/12 , A61K31/4709 , A61P25/08 , A61P25/06 , A61P25/14 , A61P25/18 , A61P25/22 , A61P13/06 , C07D413/10
CPC分类号： C07D409/12 , C07D215/54
摘要： The invention relates to substituted 2-mercaptoquinoline-3-carboxamides, methods for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
摘要翻译： 本发明涉及取代的2-巯基喹啉-3-甲酰胺，其制备方法，含有这些化合物的药物以及这些化合物在制备药物中的用途。
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8.发明授权Substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides as KCNQ2/3 modulators 有权取代的2-氧代和2-硫代二氢喹啉-3-甲酰胺作为KCNQ2 / 3调节剂公开(公告)号：US08653102B2
公开(公告)日：2014-02-18
申请号：US13218579
申请日：2011-08-26
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/54 , C07D405/04
摘要： The invention relates to substituted 2-oxo- and 2-thioxo-dihydroquinoline-3-carboxamides to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
摘要翻译： 本发明涉及取代的2-氧代 - 和2-硫代 - 二氢喹啉-3-甲酰胺与含有这些化合物的药物组合物以及用于治疗和/或预防疼痛和其它疾病和/或病症的这些化合物。
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公开(公告)号：US08653101B2
公开(公告)日：2014-02-18
申请号：US13218512
申请日：2011-08-26
IPC分类号： A61K31/04 , C07D215/38
CPC分类号： C07D215/54 , A61K31/47 , A61K45/06 , C07D215/56 , C07D409/12
摘要： The invention relates to substituted 2-oxy-quinoline-3-carboxamides, to pharmaceutical compositions containing these compounds and also to these compounds for use in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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公开(公告)号：US20120258947A1
公开(公告)日：2012-10-11
申请号：US13449472
申请日：2012-04-18
申请人： Sven KÜHNERT , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder , Simon Lucas
发明人： Sven KÜHNERT , Gregor Bahrenberg , Achim Kless , Wolfgang Schröder , Simon Lucas
IPC分类号： A61K31/5377 , C07D405/12 , A61K31/455 , C07D413/14 , C07D401/04 , C07D213/82 , C07D417/04 , A61K31/541 , A61K31/4725 , A61K31/496 , A61K31/553 , A61K31/55 , C07D491/107 , C07D471/04 , C07D487/04 , A61K31/4985 , A61K31/4709 , C07D498/08 , A61K31/5386 , A61P29/00 , A61P25/00 , A61P21/00 , A61P25/08 , A61P13/00 , A61P25/22 , A61P25/30 , A61P25/06 , A61P25/14 , A61P25/18 , C07D413/04
CPC分类号： A61K31/541 , A61K31/455 , A61K31/5377 , C07D213/82 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： Substituted 6-amino-nicotinamides, pharmaceutical compositions containing these compounds and also use of these compounds in the treatment and/or prophylaxis of pain and further diseases and/or disorders.
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