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    Buffered nicotine containing products
    2.
    发明申请
    Buffered nicotine containing products 审中-公开
    缓冲尼古丁含有产品

    公开(公告)号：US20080286340A1

    公开(公告)日：2008-11-20

    申请号：US11803747

    申请日：2007-05-16

    申请人： Sven-Borje Andersson ,  Gunnar Bergengren ,  Bengt Bosson ,  Andreas Hugerth ,  Fredrik Nicklasson ,  Roland Olsson

    发明人： Sven-Borje Andersson ,  Gunnar Bergengren ,  Bengt Bosson ,  Andreas Hugerth ,  Fredrik Nicklasson ,  Roland Olsson

    IPC分类号： A61K9/28 ,  A61K31/44 ,  A61K9/68 ,  A61P43/00

    CPC分类号： A61K9/006 ,  A23G3/44 ,  A23G4/14 ,  A23L33/175 ,  A24B15/16 ,  A61K9/0056 ,  A61K9/0058 ,  A61K31/465

    摘要： A pharmaceutical oral formulation for delivering nicotine in any form to a subject by transmucosal uptake in the oral cavity comprising nicotine in any form, wherein said oral formulation is buffered with at least one amino acid, preferably at least one endogenous amino acid. Also contemplated is a method for the oral delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as methods for manufacturing the oral formulation, the use of said oral formulation for obtaining transmucosal uptake of nicotine in the oral cavity of a subject, and use of nicotine for the production of an oral formulation as per above for the treatment of a disease selected from the group consisting of tobacco or nicotine dependence, Alzheimer's disease, Crohn's disease, Parkinson's disease, Tourette's syndrome, ulcerous colitis and post-smoking-cessation weight control.

    摘要翻译： 一种药物口服制剂，其用于通过口腔内经粘膜摄取将任何形式的尼古丁以任何形式递送至任何形式的尼古丁，其中所述口服制剂用至少一种氨基酸，优选至少一种内源性氨基酸缓冲。 还考虑了以任何形式口服输送尼古丁的方法，减少吸烟或使用烟草的欲望的方法以及制备口服制剂的方法，所述口服制剂用于获得尼古丁的经粘膜摄取 在受试者的口腔中，以及使用尼古丁制备如上所述的口服制剂用于治疗选自烟草或尼古丁依赖性疾病，阿尔茨海默氏病，克罗恩病，帕金森氏病，图雷特综合征 ，溃疡性结肠炎和戒烟后重量控制。

    Method and arrangement in a bag-making machine for forming weld lines in a web fed therethrough
    5.
    发明授权
    Method and arrangement in a bag-making machine for forming weld lines in a web fed therethrough 失效
    制袋机中的方法和布置，用于在其中馈送的网中形成焊接线

    公开(公告)号：US5215514A

    公开(公告)日：1993-06-01

    申请号：US946131

    申请日：1992-09-17

    申请人： Jan Flyghagen ,  Roland Olsson

    发明人： Jan Flyghagen ,  Roland Olsson

    IPC分类号： B29C65/18 ,  B31B23/00

    CPC分类号： B31B23/00 ,  B29C65/18 ,  B29C66/4312 ,  B29C66/83421 ,  B29C66/83511 ,  B29C66/83517 ,  B29C66/934 ,  B29C66/939 ,  B31B2219/028 ,  B31B2237/10

    摘要： An arrangement in a bag-making machine for forming weld lines in a web continuously fed through the machine, preferably a flattened plastic film tube, comprises a cylindrical, freely rotatable drum; a driving belt which is adapted to rotate the drum and pressed against part of the circumferential surface of the drum; and a number of transverse sealing jaws which, as the drum rotates, are movable into engagement with and drivable together with the web for welding the web through a predetermined angle of drum rotation. In order to achieve a high speed of the web, preferably about 150 m/min., and high flexibility in respect of the available range of bag length, the sealing jaws are freely movable relative to the drum outside the circumferential surface thereof and controlled by a control device which is adapted to hold each sealing jaw in a stand-by-position out of engagement with the web, and successively to bring each sealing jaw into engagement with the web with a certain time delay relative to each other. The welding is effected over a constant and relatively long welding distance.In a method of producing, in such a bag-making machine, weld lines in a web which is continuously fed through the machine, the sealing jaws are first held in the stand-by position out of engagement with the web and are then brought into engagement with the web and driven around the drum while performing the welding.

    摘要翻译： 用于在连续供给机器的纸幅中形成焊接线的制袋机中的布置，优选为扁平塑料薄膜管，其包括圆筒形，可自由旋转的滚筒; 驱动带，其适于旋转所述滚筒并压靠所述滚筒的所述圆周表面的一部分; 以及当滚筒旋转时，多个横向密封钳口可移动地与卷筒纸啮合并与织物一起驱动，以将卷筒纸以预定的滚筒旋转角度进行焊接。 为了实现纸幅的高速度，优选约150m /分钟，并且在袋长度的可用范围方面具有高柔性，密封钳可以相对于其外周表面上的鼓自由移动，并由 控制装置，其适于将每个密封夹持件保持在与所述幅材不接合的待机位置，并且连续地使每个密封钳口相对于彼此以一定的时间延迟与所述幅材接合。 焊接在恒定和相对较长的焊接距离下进行。 在这种制袋机中，通过机器连续供给的卷材中的焊接线的制造方法，首先将密封爪保持在备用位置，脱离与纸幅的接合，然后进入 在进行焊接时与纸幅接合并围绕滚筒驱动。

    New product and use and manufacture thereof
    6.
    发明申请
    New product and use and manufacture thereof 审中-公开
    新产品及其使用和制造

    公开(公告)号：US20070269492A1

    公开(公告)日：2007-11-22

    申请号：US11444775

    申请日：2006-06-01

    申请人： Per Steen ,  Darek Dymitrowicz ,  Asa Waltermo ,  Roland Olsson ,  Katarina Lindell

    发明人： Per Steen ,  Darek Dymitrowicz ,  Asa Waltermo ,  Roland Olsson ,  Katarina Lindell

    IPC分类号： A61K9/68 ,  A61K9/28

    CPC分类号： A61K9/0056 ,  A61K31/465

    摘要： Coated oral dosage forms for the delivery of nicotine in any form to a subject by rapid intraoral delivery of nicotine comprising at least one core, nicotine in any form and/or a nicotine mimicking agent, at least one coating layer and optionally at least one or more other additives, wherein said at last one coating layer is buffered, whereby is used at least trometamol as buffering agent. Also contemplated is a method for the delivery of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as a method for producing said coated product and the use of the same for obtaining a rapid intraoral uptake of nicotine.

    摘要翻译： 用于将任何形式的尼古丁以任何形式递送至受试者的涂覆的口服剂型包括至少一种核心，任何形式的尼古丁和/或尼古丁模拟剂，至少一种包衣层和任选的至少一种或多种 更多其它添加剂，其中所述最后一个涂层被缓冲，由此至少使用氨基甲烷酚作为缓冲剂。 还考虑了以任何形式递送尼古丁的方法，用于减少吸烟或使用烟草的欲望的方法以及用于制备所述涂覆产品的方法及其用于获得快速口内摄取的用途 尼古丁。

    COATED NICOTINE-CONTAINING CHEWING GUM, MANUFACTURE AND USE THEREOF
    9.
    发明申请
    COATED NICOTINE-CONTAINING CHEWING GUM, MANUFACTURE AND USE THEREOF 审中-公开
    包装含尼龙糖，其制造和使用

    公开(公告)号：US20120017924A1

    公开(公告)日：2012-01-26

    申请号：US13249619

    申请日：2011-09-30

    申请人： Katarina E.A. Lindell ,  Nils-Olof Lindberg ,  Roland Olsson

    发明人： Katarina E.A. Lindell ,  Nils-Olof Lindberg ,  Roland Olsson

    IPC分类号： A24F47/00 ,  A61K47/48 ,  A61K31/465 ,  A61P25/34 ,  A61P25/28 ,  A61P1/00 ,  A61P29/00 ,  A61P3/04 ,  A61K9/68 ,  A61P25/00

    CPC分类号： A23G4/06 ,  A23B4/10 ,  A23G4/046 ,  A23G4/126 ,  A23G4/20 ,  A61K9/0058 ,  A61K31/465

    摘要： A coated chewing gum product for the delivering of nicotine in any form to a subject by a rapid transmucosal uptake in the oral cavity comprising at least one gum core, nicotine in any form and/or a nicotine mimicking agent, at least one coating layer and optionally at least one or more other additive, wherein said at last one coating layer is buffered. Also contemplated is a method for the delivering of nicotine in any form, a method for the reduction of the urge to smoke or use tobacco as well as a method for producing said coated chewing gum and the use of the same form obtaining a quick transmucosal uptake of the nicotine in the oral cavity of a subject.

    摘要翻译： 一种涂覆的口香糖产品，用于通过在口腔中快速透粘膜吸收将任何形式的尼古丁输送到受试者，包括至少一种胶核心，任何形式的尼古丁和/或尼古丁模拟剂，至少一个涂层和 任选的至少一种或多种其它添加剂，其中所述最后一个涂层被缓冲。 还考虑了以任何形式递送尼古丁的方法，用于减少吸烟或使用烟草的欲望的方法以及制备所述包衣口香糖的方法以及获得快速透粘膜吸收的相同形式的使用 的尼古丁在受试者的口腔中。