公开(公告)号：US20180195137A1

公开(公告)日：2018-07-12

申请号：US15580042

申请日：2016-06-08

Applicant: Swansea University

Inventor： Paul Dyson ,  Miranda Whitten

IPC: C12R1/01 ,  C12N15/113 ,  C07K16/10 ,  A01N63/02 ,  A01N37/46 ,  C12N15/74 ,  A01N25/00

CPC classification number: C12R1/01 ,  A01N25/006 ,  A01N37/46 ,  A01N63/00 ,  A01N63/02 ,  C07K16/1036 ,  C12N15/113 ,  C12N15/746 ,  C12N2310/14

Abstract: The invention relates to a genetically transformed or transfected bacterial cell of a gut symbiont of an insect belonging to the Order Thysanoptera wherein said cell is transformed to express double-stranded RNA (dsRNA) active against at least one selected insect gene; a vector for transforming or transfecting said bacterial cell; an insect including said transformed bacterial cell and a method of pest control employing the use of said bacterial cell and/or said insect.

公开(公告)号：US11015199B2

公开(公告)日：2021-05-25

申请号：US15774569

申请日：2016-11-02

Applicant: Swansea University

Inventor： Paul Dyson

IPC: C12N15/113 ,  C12N15/88 ,  A61P35/00 ,  A61K35/74 ,  A61K35/00

Abstract: The invention relates to a genetically transformed or transfected bacterial cell chromosome wherein said cell is made to express interfering RNA (siRNA) active against at least one gene encoding a cancer promoting or sustaining protein such as an oncogene, a chemo-resistant gene or a metabolic gene; siRNA cassette encoding at least one siRNA active against said gene; a bacterial cell with said siRNA cassette integrated within the bacterial chromosome; a method of treating cancer, particularly but not exclusively prostate, breast or colorectal cancer, employing the use of said bacterial cell with a chromosomally integrated siRNA cassette; and use of said bacterial cell with a chromosomally integrated siRNA cassette to treat said cancer.

公开(公告)号：US20190112607A1

公开(公告)日：2019-04-18

申请号：US15774569

申请日：2016-11-02

Applicant: Swansea University

Inventor： Paul Dyson

IPC: C12N15/113 ,  A61P35/00 ,  A61K35/74

Abstract: The invention relates to a genetically transformed or transfected bacterial cell chromosome wherein said cell is made to express interfering RNA (siRNA) active against at least one gene encoding a cancer promoting or sustaining protein such as an oncogene, a chemo-resistant gene or a metabolic gene; siRNA cassette encoding at least one siRNA active against said gene; a bacterial cell with said siRNA cassette integrated within the bacterial chromosome; a method of treating cancer, particularly but not exclusively prostate, breast or colorectal cancer, employing the use of said bacterial cell with a chromosomally integrated siRNA cassette; and use of said bacterial cell with a chromosomally integrated siRNA cassette to treat said cancer.