公开(公告)号：US09404151B2

公开(公告)日：2016-08-02

申请号：US13695254

申请日：2011-04-28

申请人： Swetha Chandra ,  Sudip Mondal ,  Venkataraman Venkatakrishnan ,  Sathyadeep Viswanathan ,  Renjith Mahiladevi Radhakrishnan ,  Raviprakash Jayaraman ,  Chandrasekhar Bhaskaran Nair ,  Pillarisetti Venkata Subbarao

发明人： Swetha Chandra ,  Sudip Mondal ,  Venkataraman Venkatakrishnan ,  Sathyadeep Viswanathan ,  Renjith Mahiladevi Radhakrishnan ,  Raviprakash Jayaraman ,  Chandrasekhar Bhaskaran Nair ,  Pillarisetti Venkata Subbarao

IPC分类号： C12Q1/68 ,  B01L7/00 ,  C12Q3/00

CPC分类号： C12Q1/686 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/1816 ,  C12Q3/00

摘要： The present disclosure provides a non-contact real time micro Polymerase Chain Reaction (PCR) system comprising; a chip having a reaction chamber for holding a sample and an embedded metal heater below the reaction chamber for heating the sample; an optical unit comprising an associated LED driver and a photo detector amplifier placed above the chip to detect fluorescence; an induction heater mounted around the chip and inductively coupled to the metal heater; an infrared temperature sensor mounted below the chip for measuring a temperature of the metal heater, wherein the infrared temperature sensor is interfaced with a signal conditioner; and a controller interfaced with the signal conditioner and the induction heater for regulating the power to the induction heater based on feedback received from the infrared temperature sensor through the signal conditioner.

摘要翻译： 本公开提供了非接触式实时微聚合酶链式反应（PCR）系统，其包含： 具有用于保持样品的反应室和用于加热样品的反应室下面的嵌入式金属加热器的芯片; 光学单元，包括相关联的LED驱动器和放置在芯片上方以检测荧光的光电检测放大器; 安装在芯片周围并感应耦合到金属加热器的感应加热器; 安装在所述芯片下方的用于测量所述金属加热器的温度的红外温度传感器，其中所述红外温度传感器与信号调节器接口; 以及与信号调节器和感应加热器接口的控制器，其基于通过信号调节器从红外温度传感器接收的反馈来调节对感应加热器的电力。

公开(公告)号：US20130101983A1

公开(公告)日：2013-04-25

申请号：US13695254

申请日：2011-04-28

申请人： Swetha Chandra ,  Sudip Mondal ,  Venkataraman Venkatakrishnan ,  Sathyadeep Viswanathan ,  Renjith Mahiladevi Radhakrishnan ,  Raviprakash Jayaraman ,  Chandrasekhar Bhaskaran Nair ,  Pillarisetti Venkata Subbarao

发明人： Swetha Chandra ,  Sudip Mondal ,  Venkataraman Venkatakrishnan ,  Sathyadeep Viswanathan ,  Renjith Mahiladevi Radhakrishnan ,  Raviprakash Jayaraman ,  Chandrasekhar Bhaskaran Nair ,  Pillarisetti Venkata Subbarao

IPC分类号： C12Q1/68 ,  C12Q3/00

CPC分类号： C12Q1/686 ,  B01L7/52 ,  B01L2200/027 ,  B01L2200/0684 ,  B01L2200/147 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2300/1816 ,  C12Q3/00

摘要： The present disclosure provides a non contact real time micro Polymerase Chain Reaction [PCR] system comprises; a chip having a reaction chamber for holding a sample and an embedded metal heater below the reaction chamber for heating the sample; an optical unit comprising associated LED driver and photo detector amplifier placed above the chip to detect the fluorescence; an induction heater mounted around the chip and is inductively coupled to the metal heater; an infrared temperature sensor mounted below the chip for measuring a temperature of the metal heater, wherein said infrared temperature sensor is interfaced with a signal conditioner; and a controller interfaced with the signal conditioner and the induction heater for regulating the power to the induction heater based on feedback received from the infrared temperature sensor through the signal conditioner.

摘要翻译： 本公开提供了非接触式实时微聚合酶链式反应[PCR]系统，包括： 具有用于保持样品的反应室和用于加热样品的反应室下面的嵌入式金属加热器的芯片; 光学单元，包括放置在芯片上方的相关联的LED驱动器和光电检测放大器，以检测荧光; 感应加热器，安装在芯片周围，并感应耦合到金属加热器; 安装在所述芯片下方的用于测量所述金属加热器的温度的红外温度传感器，其中所述红外温度传感器与信号调节器接口; 以及控制器，其与信号调节器和感应加热器接口，用于基于通过信号调节器从红外温度传感器接收的反馈来调节对感应加热器的电力。