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公开(公告)号：US12054549B2
公开(公告)日：2024-08-06
申请号：US18050817
申请日：2022-10-28
申请人： Merck Patent GmbH
发明人： Ilhan Celik , Eike Staub , Miriam Urban , Sabine Raab-Westphal , Eileen Samy , Andrew Bender , Georgianna Varrone , Yin Wu , Daigen Xu
IPC分类号： A61K39/00 , A61K39/395 , A61P11/00 , A61P17/02 , C07K16/28 , C12Q3/00 , G01N33/543
CPC分类号： C07K16/2848 , A61K39/395 , A61P11/00 , A61P17/02 , C07K16/2839 , C12Q3/00 , G01N33/54366 , A61K2039/505 , C07K2317/24 , C07K2317/73 , C07K2317/76
摘要： A method can treat a patient suffering from at least one of fibrosis and a fibrotic disorder. The method includes administering a therapeutically effective amount of an anti-αv integrin antibody DI17E6, or a biologically active variant or modification thereof, to the patient.
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公开(公告)号：US11873474B2
公开(公告)日：2024-01-16
申请号：US17477019
申请日：2021-09-16
发明人： Daniel P. Welch , John R. Wilson
摘要： Novel methods and apparatus are disclosed for cell culture and cell recovery. The methods and apparatus simplify the process of cell separation from media, minimize potential damage to gas permeable devices during fluid handling, and allow closed system automated cell culture and cell recovery from gas permeable devices.
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公开(公告)号：US11788114B2
公开(公告)日：2023-10-17
申请号：US16510253
申请日：2019-07-12
申请人： QVELLA CORPORATION
发明人： Samad Talebpour , Aye Aye Khine , Robert Maaskant , Tino Alavie
IPC分类号： C12M1/42 , C12M1/00 , C12N1/06 , C12N1/08 , C12N13/00 , C12Q1/6806 , C12Q3/00 , C12Q1/686 , B01L3/00 , B01L7/00
CPC分类号： C12Q1/6806 , B01L3/502715 , B01L3/502738 , B01L3/502753 , B01L7/52 , C12M35/02 , C12M47/06 , C12N1/066 , C12N1/08 , C12N13/00 , C12Q1/686 , C12Q3/00 , B01L2200/0631 , B01L2200/143 , B01L2300/0645 , B01L2300/0681 , B01L2300/087 , B01L2300/0809 , B01L2300/0858 , B01L2300/0874 , B01L2300/0887 , B01L2300/14 , B01L2300/1833 , B01L2400/0694
摘要： Devices and methods are provided for electrically lysing cells and releasing macromolecules from the cells. A microfluidic device is provided that includes a planar channel having a thickness on a submillimeter scale, and including electrodes on its upper and lower inner surfaces. After filling the channel with a liquid, such that the channel contains cells within the liquid, a series of voltage pulses of alternating polarity are applied between the channel electrodes, where the amplitude of the voltage pulses and a pulse width of the voltage pulses are effective for causing irreversible electroporation of the cells. The channel is configured to possess thermal properties such that the application of the voltage produces a rapid temperature rise as a result of Joule heating for releasing the macromolecules from the electroplated cells. The channel may also include an internal filter for capturing and concentrating the cells prior to electrical processing.
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公开(公告)号：US20230193180A1
公开(公告)日：2023-06-22
申请号：US18169961
申请日：2023-02-16
申请人： Terumo BCT, Inc.
CPC分类号： C12M23/20 , C12M29/16 , C12M41/48 , C12M41/00 , C12M23/50 , C12Q3/00 , C12N5/0662 , C12M25/10 , B05D7/22 , C12M27/10 , C12M29/18 , C12M25/12 , C12N5/0663 , C12M29/10 , C12M1/36 , B05D2259/00 , B05D2254/00
摘要： Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface in some embodiments. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber in a bioreactor, by controlling the movement of a fluid in which a coating agent is suspended, by changing flow rates, by changing flow directions, by rotation of the bioreactor, and/or combinations thereof.
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公开(公告)号：US20190217302A1
公开(公告)日：2019-07-18
申请号：US16245537
申请日：2019-01-11
申请人： Fluidigm Corporation
发明人： Jake Kimball , Brandon Ripley , Gang Sun , Dominique Toppani , Myo Thu Maung
CPC分类号： B01L7/52 , B01L3/5027 , B01L2200/025 , B01L2200/147 , B01L2300/0819 , B01L2300/0893 , B01L2300/1805 , B01L2300/1822 , C12P19/34 , C12Q3/00 , G01N21/6408 , G01N21/6428 , G01N21/6456 , G01N21/76
摘要： A thermal cycler for a microfluidic device includes a controller operable to provide a series of electrical signals, a heat sink, and a heating element in thermal communication with the heat sink and operable to receive the series of electrical signals from the controller. The thermal cycler also includes a thermal chuck in thermal communication with the heating element. The thermal chuck comprises a heating surface operable to make thermal contact with the microfluidic device. The heating surface is characterized by a temperature ramp rate between 2.5 degrees Celsius per second and 5.5 degrees Celsius per second and a temperature difference between a first portion of the heating surface supporting a first portion of the microfluidic device and a second portion of the heating surface supporting a second portion of the microfluidic device is less than 0.25° C.
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公开(公告)号：US20180274045A1
公开(公告)日：2018-09-27
申请号：US15989398
申请日：2018-05-25
发明人： Keith Nelson
CPC分类号： C12Q3/00 , C05F17/0072 , C05F17/0282 , C12M41/48 , Y02P20/145 , Y02W30/43
摘要： A controller for a compost system comprises a plurality of control outputs in communication with a plurality of compost devices. The control outputs are configured to identify an error condition of at least one of the plurality of compost devices. The controller is configured to control a first compost device configured to control a first environmental condition and control a second compost device configured to control a second environmental condition of a compost chamber. The controller is further configured to deactivate the first compost device in response to an error condition during a compost cycle. The controller controls the second compost device in response to the first compost device being deactivated preserving the compost cycle by compensating for the error condition in the first compost device.
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公开(公告)号：US09920292B2
公开(公告)日：2018-03-20
申请号：US14841072
申请日：2015-08-31
CPC分类号： C12M41/22 , C12M21/08 , C12M23/14 , C12M23/38 , C12M23/48 , C12M27/16 , C12M29/24 , C12M41/48 , C12Q3/00
摘要： System and methods are provided for initiating a cell culture. The systems and methods include a first enclosure containing a thermal mass positioned on a surface area of a platform. The systems and methods include a second enclosure, containing a culture fluid and a gas mixture, placed on the first enclosure such that the first enclosure is positioned between the second enclosure and the platform. The systems and methods further include a cover secured on the second enclosure, and generating first thermal energy on the surface area of the platform and second thermal energy from the cover.
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公开(公告)号：US20180072972A1
公开(公告)日：2018-03-15
申请号：US15701241
申请日：2017-09-11
发明人： Jong-Wook Shin , Yoon-Sang Kim , Sang-Hyuck Oh , Byung-Kyu Kang
IPC分类号： C12C13/10
摘要： Systems, devices, and methods for the automated production of fermented beverages are provided. The device may be modular, portable and/or self-cleaning. The device includes a housing with chambers that receive a removable fermentation vessel with yeasts and ingredients capable of undergoing fermentation. Flavoring agents and other ingredients may also be added to produce beer, wine, or other alcoholic libations of profound character and freshness. The device includes a controller that initiates fermentation, senses the fermentation status and automatically controls fermentation parameters based on a desired fermentation profile. The controller automatically directs parameters such as carbonation, conditioning, aging, and chilling according to a programmed recipe or consumer preference to create an enjoyable customized beverage.
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公开(公告)号：US20180037864A1
公开(公告)日：2018-02-08
申请号：US15726060
申请日：2017-10-05
发明人： Daniel P. Welch , John R. Wilson
摘要： Novel methods and apparatus are disclosed for cell culture and cell recovery. The methods and apparatus simplify the process of cell separation from media, minimize potential damage to gas permeable devices during fluid handling, and allow closed system automated cell culture and cell recovery from gas permeable devices.
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10.发明申请公开(公告)号：US20170267965A1
公开(公告)日：2017-09-21
申请号：US15528691
申请日：2015-11-17
发明人： Christian CUREL , Michel ROCH
CPC分类号： C12M41/36 , C12M25/06 , C12M33/00 , C12M41/48 , C12Q3/00 , G01N21/55 , G01N21/8422 , G01N2021/8433 , G01N2201/0612 , G06T7/0012 , G06T2207/30024
摘要： A method for detecting inoculation in order to detect inoculation with a sample of a solid culture medium (21) present in a layer on a culture plate (20), said culture plate (20) being positioned on a support (2), said method comprising a step of projecting an incident light flux towards said support (2) in order to allow oblique illumination of the surface referred to as the inoculation surface (22) of said culture medium (21) of the culture plate (20) when the culture plate (20) is provided in the disposed state on said support (2), a step of displaying, on a display area (41) of a display screen (4), a two-dimensional image of the incident light flux reflected by the inoculation surface (22) of the culture plate (20) in the illuminated state illuminated by the means (3) for projecting a light flux, and a step of photographing the display area (41) of the screen (4).
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