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公开(公告)号:US6071945A
公开(公告)日:2000-06-06
申请号:US361064
申请日:1999-07-26
申请人: Sylvain Rault , Cecile Enguehard , Jean-Charles Lancelot , Max Robba , Ghanem Atassi , Alain Pierre , Daniel-Henri Caignard , Pierre Renard
发明人: Sylvain Rault , Cecile Enguehard , Jean-Charles Lancelot , Max Robba , Ghanem Atassi , Alain Pierre , Daniel-Henri Caignard , Pierre Renard
IPC分类号: A61K31/00 , A61K31/40 , A61K31/407 , A61P35/00 , C07D495/14
CPC分类号: C07D495/14 , Y02P20/55
摘要: A compound selected from those of formula (I): ##STR1## wherein: R.sub.1 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino,R.sub.2 represents optionally substituted aryl or heteroaryl,R.sub.3 represents hydrogen, halogen, alkyl, nitro, hydroxy, alkoxy, trihaloalkyl, trihaloalkoxy or optionally substituted amino,their isomers and addition pharmaceutically-acceptable acid or base salts thereof and medicinal products containing the same are useful in the treatment of cancer.
摘要翻译: 选自式(I)的化合物:其中:R 1表示氢,卤素,烷基,硝基,羟基,烷氧基,三卤代烷基,三卤代烷氧基或任选取代的氨基,R 2表示任选取代的芳基或杂芳基,R 3表示氢, 硝基,羟基,烷氧基,三卤代烷基,三卤代烷氧基或任选取代的氨基,它们的异构体及其加成药学上可接受的酸或碱盐和含有它们的药物可用于治疗癌症。